Dr. Johann Gudjonsson, MD

• Dermatology

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• University Of Iceland Laeknadeild

  Medical School

• NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation, 2021-02-02

• Induction of alternative proinflammatory cytokines accounts for sustained psoriasiform skin inflammation in IL-17C+IL-6KO mice, 2016-10-27

• Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterol crystal formation in Endothelial cells partly through modulation of Lysosomal pH and Cholesterol homeostasis, 2020-07-06

• 68thMontagna Symposium on the Biology of Skin "Decoding Complex Skin Diseases: Integrating Genetics, Genomics, and Disease Biology”, 2020-06-27

• Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis, 2017-03-09

• Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab, 2021-11-29

• The Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas, 2021-06-24

• The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal, 2016-12-09

• Targeted treatment for erythrodermic psoriasis: rationale and recent advances, 2020-03-24

• Endogenous glucocorticoid deficiency in psoriasis promotes inflammation and abnormal differentiation, 2017-03-01

• Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair, 2022-09-20

• VGLL3-regulated gene network as a promoter of sex biased autoimmune diseases, 2016-12-19

• Loss of interleukin-1 beta is not protective in the lupus-prone NZM2328 mouse model, 2023-05-16

• MCPIP1/Regnase-1 restricts IL-17A- and IL-17C-dependent skin inflammation, 2016-12-05

• Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-atherapy, 2020-10-02

• Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin, 2015-01-30

• Anti-NET antibodies and impaired NET degradation in antiphospholipid syndrome, 2020-10-16

• Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris, 2021-10-22

• Single Cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms, 2022-06-28

• Targeting immune cell trafficking and vascular endothelial cells in psoriasis, 2023-05-01

• Shared genetic risk factors and causal association between psoriasis and coronary artery disease, 2022-11-02

• Psoriasis: A mixed autoimmune and autoinflammatory disease, 2017-07-22

• Deficiency of myeloid-related proteins 8 and 14 (Mrp8/Mrp14) does not block inflammaging but prevents steatosis, 2016-05-21

• Accumulating Evidence for the Association and Shared Pathogenic Mechanisms between Psoriasis and Cardiovascular-Related Co-morbidities, 2014-08-19

• Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair, 2020-03-23

• Cross-disease transcriptomics: Unique IL-17A signaling in psoriasis lesions and an autoimmune PBMC signature, 2016-05-17

• B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity, 2021-11-19

• Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells, 2019-06-24

• Psoriasis: Past, Present, and Future, 2019-12-26

• Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis, 2023-06-12

• New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine, 2021-07-22

• Sebaceous gland atrophy in psoriasis: An explanation for psoriatic alopecia?, 2016-06-14

• STEAPs comprise a novel inflammatory nexus in pustular skin disorders, 2016-11-21

• Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems, 2023-06-02

• Single-cell transcriptomics reveals distinct effector profiles of infiltrating T cells in lupus skin and kidney, 2022-04-22

• The Emerging Role of Interleukin-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings, 2012-06-07

• Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin, 2020-10-15

• Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk, 2019-04-05

• Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies, 2020-10-13

• Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-? activation and APOBEC3G induction, 2023-05-01

• GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states, 2017-04-26

• Transcriptome classification reveals molecular subtypes in psoriasis, 2012-09-12

• Biologics in the treatment of skin and rheumatologic diseases, 2020-02-27

• IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA-binding protein Arid5a, 2018-10-09

• IL-36 promotes myeloid cell infiltration, activation and inflammatory activity in skin, 2014-05-14

• Research Techniques Made Simple: Murine Models of Human Psoriasis, 2019-11-19

• SIRT3 Regulates Macrophage-Mediated Inflammation in Diabetic Wound Repair, 2019-06-15

• Molecular Profiling of Cutaneous Lupus Lesions Identifies Subgroups Distinct from Clinical Phenotypes, 2019-08-17

• IL-1F5, F6, F8, and F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression, 2011-01-17

• The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair, 2019-07-23

• 4421 Exposure to topical antimicrobials reduces inflammatory gene expression in keratinocytes, 2020-06-01

• Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis, 2017-03-17

• EGFR and IL-1 signaling synergistically promote keratinocyte antimicrobial defenses in a differentiation-dependent manner, 2010-10-21

• Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related toIL36G, 2022-08-22

• Identification of fifteen new psoriasis susceptibility loci highlights the role of innate immunity, 2012-11-11

• Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease, 2023-09-22

• Drug repurposing prediction for immune-mediated cutaneous diseases using a word-embedding based machine learning approach, 2018-10-17

• Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity, 2018-10-23

• TREM2 macrophages induced by human lipids drive inflammation in acne lesions, 2022-07-22

• Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture, 2014-10-13

• Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci, 2015-05-05

• Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms, 2014-01-17

• Non-lesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation, 2022-04-27

• Genomewide Scan Reveals Association of Psoriasis with IL-23 and NF-?B Pathways, 2009-01-25

• Roles Played by Stress-Induced Pathways in Driving Ethnic Heterogeneity for Inflammatory Skin Diseases, 2022-04-28

• The Influence of Interferon on Healthy and Diseased Skin, 2018-12-06

• Senescent Cells Accumulate in Systemic Sclerosis Skin, 2022-09-30

• Placental transcriptome analysis of hypertensive pregnancies identifies distinct gene expression profiles of preeclampsia superimposed on chronic hypertension, 2023-05-02

• Mouse Models of Psoriasis - A Comprehensive Review, 2021-12-23

• Psoriasis and the MAITing game: A role for IL-17A+ invariant TCR CD8+ T cells in psoriasis?, 2014-08-15

• Differentiation of IL-26+TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis, 2023-06-30

• IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses, 2021-04-15

• Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne, 2022-02-16

• Comparison of lesional juvenile myositis and lupus skin reveals overlapping yet unique disease pathophysiology, 2021-05-02

• Treatment of cutaneous lupus erythematosus: current approaches and future strategies, 2020-06-20

• Lupus skin is primed for IL-6 inflammatory responses through a keratinocyte-mediated autocrine type I interferon loop, 2016-09-16

• Staphylococcus aureuscolonization is increased on lupus skin lesions and is promoted by interferon-mediated barrier disruption, 2019-12-23

• Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation, 2013-01-28

• CREB1-driven CXCR4hineutrophils promote skin inflammation in mouse models and human patients, 2023-09-22

• Vitamin D3and deconvoluting a rash, 2023-01-24

• Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes, 2022-08-22

• Application of Machine Learning to Determine Top Predictors of Non-calcified Coronary Burden in Psoriasis: an Observational Cohort Study., 2019-10-31

• Sex Bias in Autoimmunity, 2018-12-04

• Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial, 2022-09-08

• IFN-? Is a Rheostat for Development of Psoriasiform Inflammation, 2021-08-05

• Adalimumab in Psoriasis: How Much is Enough?, 2020-06-20

• IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis, 2016-12-31

• IFN-? enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus, 2019-09-25

• RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature, 2018-01-29