Dr. Edwin Silverman, MD

Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter Syndrome, 2015-04-30

Gene expression analysis uncovers novel Hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells, 2013-03-01

Author Correction: Cluster analysis categorizes five phenotypes of pulmonary tuberculosis, 2023-01-25

A comparison of visual and quantitative methods to identify interstitial lung abnormalities, 2015-10-29

Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue, 2017-03-13

Asthma-susceptibility variants identified using probands in case-control and family-based analyses, 2010-08-10

Beyond GWAS in COPD: Probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks, 2014-08-27

A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes, 2017-01-12

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk, 2023-03-13

Heritability Analyses Uncover Shared Genetic Effects of Lung Function and Change over Time, 2022-07-15

Genetic variation in the mitochondrial glycerol-3-phosphate acyltransferase is associated with liver injury, 2021-11-09

CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells, 2022-07-01

Aberrant activation of TCL1A promotes stem cell expansion in clonal hematopoiesis, 2023-04-12

Visual Assessment of CT Findings in Smokers With Nonobstructed Spirometric Abnormalities in The COPDGene®Study, 2014-08-14

Combining Disease Models to Test for Gene-Environment Interaction in Nuclear Families, 2011-03-14

Integration of Mouse and Human Genome-Wide Association Data IdentifiesKCNIP4as an Asthma Gene, 2013-02-14

DNAH5is associated with total lung capacity in chronic obstructive pulmonary disease, 2014-08-20

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations, 2019-02-25

Rare genetic variants explain missing heritability in smoking, 2022-08-04

Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD, 2013-04-08

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes, 2018-07-03

GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing, 2022-08-11

Quantitative CT Measurement of Cross-sectional Area of Small Pulmonary Vessel in COPD: Correlations with Emphysema and Airflow Limitation, 2009-09-30

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside, 2021-03-30

Genetic association analysis of COPD candidate genes with bronchodilator responsiveness, 2008-12-25

Association Between Interstitial Lung Abnormalities and All-Cause Mortality, 2016-02-16

Hepatitis C and HIV detection by blood RNA-sequencing in cohort of smokers, 2023-01-24

Relationship of Emphysema and Airway Disease Assessed by CT to Exercise Capacity in COPD, 2010-04-10

THE CLINICAL IMPACT OF NON-OBSTRUCTIVE CHRONIC BRONCHITIS IN CURRENT AND FORMER SMOKERS, 2013-11-15

Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans, 2015-02-05

locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies, 2020-09-14

A Simplified Score to Quantify Comorbidity in COPD, 2014-12-16

FARVATX: FAmily-based Rare Variant Association Test for X-linked genes, 2016-06-21

Integrated transcriptomic correlation network analysis identifies COPD molecular determinants, 2020-02-25

Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) is associated with features of and progression to obstructive lung disease, 2020-03-20

Genetics of Sputum Gene Expression in Chronic Obstructive Pulmonary Disease, 2011-09-16

The Association of a SNP Upstream ofINSIG2with Body Mass Index is Reproduced in Several but Not All Cohorts, 2007-04-27

The clinical features of the overlap between COPD and asthma, 2011-09-27

Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease, 2014-09-21

Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research, 2018-03-22

Association ofIREB2andCHRNA3polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency, 2012-02-22

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts, 2020-07-01

Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD, 2014-06-25

RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD, 2019-04-02

Validation of a method to assess emphysema severity by spirometry in the COPDGene study, 2020-05-01

Paradoxical Lung Function Response to Beta2-agonists: Radiologic Correlates and Clinical Implications, 2014-09-09

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations, 2019-12-23

Screening for interaction effects in gene expression data, 2017-03-16

Cluster Analysis in the COPDGene Study Identifies Subtypes of Smokers with Distinct Patterns of Airway Disease and Emphysema, 2014-02-21

Characterisation of COPD heterogeneity in the ECLIPSE cohort, 2010-09-10

ADAM15 expression is increased in lung CD8+T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction, 2020-07-16

Chest CT Derived Low Fat-Free Mass Index and Mortality in COPD, 2017-12-14

Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection, 2019-09-25

TheMUC5BPromoter Polymorphism Is Associated with Specific Interstitial Lung Abnormality Subtypes, 2017-09-11

Implications of the GOLD 2011 Disease Severity Classification in the COPDGene Cohort, 2012-09-03

Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene, 2019-07-03

Airway wall thickness is increased in COPD patients with bronchodilator responsiveness, 2014-08-08

Alternative poly-adenylation modulates a1-antitrypsin expression in chronic obstructive pulmonary disease, 2021-11-16

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets, 2017-02-06

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis, 2014-02-07

Association between titin loss-of-function variants and early-onset atrial fibrillation, 2018-12-11

DO "COPD SUBTYPES” REALLY EXIST? Assessment of COPD Heterogeneity and Clustering Reproducibility in 17,154 Individuals Across Ten Independent Cohorts, 2017-06-21

Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility, 2013-01-09

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD, 2021-04-27

Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study, 2018-10-29

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene, 2014-08-06

Gene-based Segregation Method for Identifying Rare Variants in Family-based Sequencing Studies, 2017-02-13

Increased mortality associated with frequent exacerbations in COPD patients with mild-to-moderate lung function impairment, and smokers with normal spirometry, 2020-12-29

Structural variation across 138,134 samples in the TOPMed consortium, 2023-02-03

Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke, 2018-08-24

Risk Factors for Venous Thromboembolism in Chronic Obstructive Pulmonary Disease, 2015-03-20

Gender differences in COPD: are women more susceptible to smoking effects than men?, 2013-06-10

Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed, 2022-01-13

On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies, 2009-11-26

Quantitative airway assessment on computed tomography in patients with a1-antitrypsin deficiency, 2010-09-09

Molecular Networks in Network Medicine: Development and Applications, 2020-04-19

COPD subtypes identified by network-based clustering of blood gene expression, 2016-01-08

Structural variation across 138,134 samples in the TOPMed consortium, 2023-01-25

PHENOTYPIC AND GENETIC HETEROGENEITY AMONG SUBJECTS WITH MILD AIRFLOW OBSTRUCTION IN COPDGENE, 2014-08-11

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis, 2017-02-06

A global network for network medicine, 2020-08-31

Asthma, Chronic Obstructive Pulmonary Disease, and Subsequent Risk for Incident Rheumatoid Arthritis among Women: A Prospective Cohort Study, 2020-04-03

Inherited Causes of Clonal Hematopoiesis in 97,691 TOPMed Whole Genomes, 2020-10-14

Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study, 2014-04-27

Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma, 2019-10-28

Sex-specific features of emphysema among current and former smokers with COPD, 2015-11-05

Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome, 2020-02-10

metaFARVAT: An Efficient Tool for Meta-Analysis of Family-Based, Case-Control, and Population-Based Rare Variant Association Studies, 2019-06-19

Racial Differences in CT Phenotypes in COPD, 2015-01-31

Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study, 2014-04-08

Optimism is associated with respiratory symptoms and functional status in chronic obstructive pulmonary disease, 2022-01-29

Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, 2022-04-21

Lung Mass in Smokers, 2016-12-08

Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability, 2015-06-20

Pulmonary artery enlargement and mortality risk in moderate to severe COPD: results from COPDGene, 2020-02-12

Interstitial lung abnormalities are associated with decreased mean telomere length, 2022-08-25

Assessment of community efforts to advance network-based prediction of protein-protein interactions, 2023-03-22

Correction to: RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking, 2019-11-18

Epidemiology, radiology, and genetics of nicotine dependence in COPD, 2011-01-13

Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies, 2022-06-17

AUTOMATIC AIRWAY ANALYSIS FOR GENOME-WIDE ASSOCIATION STUDIES IN COPD, 2013-05-17

Opportunities and Challenges in the Genetics of COPD 2010: An International COPD Genetics Conference Report, 2011-04-15

The value of blood cytokines and chemokines in assessing COPD, 2017-10-24

High Resolution Melting Curve Analysis of Genomic and Whole Genome Amplified DNA, 2009-09-16

GWAS and Systems Biology Analysis of Depressive Symptoms among Smokers from the COPDGene Cohort, 2018-09-07

Interaction of Cigarette Smoking and Polygenic Risk Score on Reduced Lung Function Interaction of Cigarette Smoking and Polygenic Risk Score on Reduced Lung Function, 2021-12-16

X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study, 2023-02-01

Peripheral blood gene expression profiles in COPD subjects, 2011-04-24

Folliculin mutations are not associated with severe COPD, 2008-12-30

Collapsibility of lung volume by paired inspiratory and expiratory CT scans: Correlations with lung function and mean lung density, 2010-01-12

Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer, 2018-07-04

Association of COPD candidate genes with CT emphysema and airway phenotypes in severe COPD, 2010-06-04

Genome-wide assessment of gene-by-smoking interactions in COPD, 2018-06-18

Genome-wide association study of smoking behaviors in COPD patients, 2011-06-16

Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD, 2020-10-29

DSPvariants may be associated with longitudinal change in quantitative emphysema, 2019-07-19

A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data, 2022-01-06

Benchmarking omics-based prediction of asthma development in children, 2023-02-26

Modifying Effects of theHFEPolymorphisms on the Association between Lead Burden and Cognitive Decline, 2007-05-10

Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease, 2019-02-11

Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease, 2022-03-24

Identification of putative causal loci in whole-genome sequencing data via knockoff statistics, 2021-05-25

Blood eosinophil thresholds and exacerbations in chronic obstructive pulmonary disease, 2018-04-28

Associations ofIL6polymorphisms with lung function decline and COPD, 2009-04-08

Integrative genomics identifies new genes associated with severe COPD and emphysema, 2018-03-22

Developing New Drug Treatments in the Era of Network Medicine, 2012-10-15

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci, 2009-03-20

Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort, 2014-06-03

Family-based Rare Variant Association Analysis: a Fast and Efficient Method of Multivariate Phenotype Association Analysis, 2016-06-17

Identifying chronic obstructive pulmonary disease from integrative omics and clustering in lung tissue, 2023-04-11

Network Medicine Approaches to the Genetics of Complex Diseases, 2013-01-04

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD, 2016-08-17

Intrathoracic tracheal volume and collapsibility on inspiratory and end-expiratory CT scans: Correlations with lung volume and pulmonary function in 85 smokers, 2011-01-06

A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study, 2009-03-20

Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study, 2009-09-24

Association of body mass index and COPD exacerbation among patients with chronic bronchitis, 2022-03-07

Multi-ethnic genome-wide and HLA association study of total serum IgE, 2021-09-15

Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease, 2018-01-15

Heme metabolism genes Downregulated in COPD Cachexia, 2020-05-01

Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD, 2023-01-19

Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis, 2019-01-08

Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine, 2020-02-26

Estimating drivers of cell state transitions using gene regulatory network models, 2017-12-13

Effect of 6p21 region on lung function is modified by smoking: a genome-wide interaction study, 2020-08-04

Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease, 2011-09-15

A genome-wide association study of quantitative computed tomographic emphysema in Korean populations, 2021-08-17

Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus, 2014-10-24

Dissecting genetics for chronic mucus hypersecretion in smokers with and without COPD genome wide analysis on mucus hypersecretion, 2014-09-18

Pulmonary Predictors of Incident Diabetes in Smokers, 2016-10-23

Pectoralis muscle area and mortality in smokers without airflow obstruction, 2018-04-10

Lung Extraction, Lobe Segmentation and Hierarchical Region Assessment for Quantitative Analysis on High Resolution Computed Tomography Images?, 2011-03-02

Rare deleterious germline variants and risk of lung cancer, 2021-02-16

A Between Ethnicities Comparison of Chronic Obstructive Pulmonary Disease Genetic Risk, 2020-04-21

Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants, 2020-10-14

Identifying a deletion affecting total lung capacity among subjects in the COPDGene study cohort, 2015-12-07

ß-blockers are associated with a reduction in COPD exacerbations, 2015-08-17

A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry, 2015-12-03

Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study, 2016-10-06

Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study, 2016-12-01

Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module, 2018-09-27

Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk, 2023-09-25

Turning Subtypes into Disease Axes to Improve Prediction of COPD Progression, 2019-06-12

Statistical considerations for the analysis of massively parallel reporter assays data, 2020-07-18

Author Correction: Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome, 2021-04-19

DNA methylation perturbations may link altered development and aging in the lung, 2021-01-19

Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery, 2007-08-08

Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain, 2021-06-22

Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma, 2017-02-17

WISARD: workbench for integrated superfast association studies for related datasets, 2018-04-20

Selecting cases and controls for DNA sequencing studies using family histories of disease, 2017-02-21

Sexually-dimorphic targeting of functionally-related genes in COPD, 2014-11-28

Subjects with diffuse idiopathic skeletal hyperostosis have an increased burden of coronary artery disease: An evaluation in the COPDGene cohort, 2019-05-30

RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking, 2017-10-06

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program, 2021-02-10

Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes, 2023-06-23

A Polygenic Risk Score and Age of Diagnosis of Chronic Obstructive Pulmonary Disease, 2022-09-15

Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease, 2013-11-06

Admixture Mapping Identifies a Quantitative Trait Locus Associated with FEV1/FVC in the COPDGene Study, 2014-08-11

COPD association and repeatability of blood biomarkers in the ECLIPSE cohort, 2011-11-04

Variants inFAM13Aare associated with chronic obstructive pulmonary disease, 2010-02-21

Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring, 2015-02-14

Clinical Predictors of Frequent Exacerbations in Subjects with Severe Chronic Obstructive Pulmonary Disease (COPD), 2010-12-10

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries., 2019-02-25

Cardiovascular Disease is Associated with COPD Severity and Reduced Functional Status and Quality of Life, 2014-05-15

Clinical and Radiographic Correlates of Hypoxemia and Oxygen Therapy in the COPDGene Study, 2011-03-10

Relationship between rheumatoid arthritis and pulmonary function measures on spirometry in the UK Biobank, 2021-09-26

On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, 2017-03-20

Polygenic Risk Scores for Chronic Obstructive Pulmonary Disease and Related Phenotypes in Population-based and Case-control Cohorts, 2020-07-17

Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation, 2010-03-16

A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease, 2014-03-13

Genetic Epidemiology of COPD (COPDGene) Study Design, 2010-08-05

The clinical and genetic features of the COPD asthma overlap syndrome, 2014-05-29

Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice, 2016-01-11

It's more than low BMI: prevalence of cachexia and associated mortality in COPD, 2019-05-22

Pulmonary Function and Emphysema in Williams-Beuren Syndrome, 2012-06-29

Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease, 2018-10-23

The Relationship between Small Pulmonary Vascular Alteration and Aortic Atherosclerosis in Chronic Obstructive Pulmonary Disease: Quantitative CT Analysis, 2010-10-13

Hierarchical association of COPD to principal genetic components of biological systems, 2023-05-25

Improved prediction of smoking status via isoform-aware RNA-seq deep learning models, 2021-10-11

The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations, 2022-05-03

A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables, 2022-11-16

Automatic Lung Lobe Segmentation Using Particles, Thin Plate Splines, and Maximum a Posteriori Estimation, 2011-02-15

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors, 2021-07-14

Cluster analysis categorizes five phenotypes of pulmonary tuberculosis, 2022-06-16

Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype, 2012-05-18

Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease, 2017-05-31