Dr. William Pu, MD

• Pediatric Cardiology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Boston Children's Hospital

  Fellowship Hospital, 1999

• Boston Children's Hospital

  Residency Hospital, 1996

• Boston Children's Hospital

  Internship Hospital, 1994

• Harvard Medical School

  Medical School, 1993

• Yale University

  Undergraduate School, 1988

• English

• Spanish

• CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy, 2012-02-16

• Insights into the pathogenesis of catecholaminergic polymorphic ventricular tachycardia from engineered human heart tissue, 2019-07-17

• Author Correction: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation, 2021-08-19

• Strategies for cardiac regeneration and repair, 2014-06-04

• Gene therapy for catecholaminergic polymorphic ventricular tachycardia by inhibition of Ca2+/calmodulin-dependent kinase II, 2019-06-03

• Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types, 2016-06-03

• VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis, 2017-08-29

• WT1 maintains adrenal-gonadal-primordium (AGP) identity and marks a novel population of AGP-like progenitors within the adult adrenal gland, 2013-10-14

• Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease, 2014-09-24

• Genetic and epigenetic control of heart development, 2020-07-01

• Releasing Yap from an a-catenin trap increases cardiomyocyte proliferation, 2015-01-02

• Experimental Models of Barth Syndrome, 2021-08-15

• Identification of a Cardiac Disease Modifier Gene Using Forward Genetics in the Mouse, 2009-09-18

• Inducible Cardiomyocyte-Specific Gene Disruption Directed by the RatTnnt2Promoter in the Mouse, 2009-10-27

• Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease, 2012-06-08

• Circulation Research Compendium - Cardiac Regeneration: Lessons from Development, 2017-03-17

• Modeling humanTBX5haploinsufficiency predicts regulatory networks for congenital heart disease, 2020-12-14

• Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts, 2016-12-17

• Heart Failure Associated Changes in RNA Splicing of Sarcomere Genes, 2010-02-02

• CASAAV: a CRISPR based platform for rapid dissection of gene functionin vivo, 2017-10-02

• De Novo Formation of a Distinct Coronary Vascular Population in Neonatal Heart, 2014-07-04

• Enhancing the precision of genetic lineage tracing using dual recombinases, 2017-11-13

• Trbp regulates heart function through miRNA-mediatedSox6repression, 2015-06-01

• ConditionalGata4deletion in mice induces bile acid absorption in the proximal small intestine, 2010-10-22

• Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure, 2019-01-04

• Molecular mechanisms of arrhythmogenic cardiomyopathy, 2019-11-10

• A tissue-engineered scale model of the heart ventricle, 2018-07-23

• Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction, 2019-04-17

• Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart, 2016-03-14

• Pi3kcbLinks Hippo-YAP and PI3K-AKT Signaling Pathways to Promote Cardiomyocyte Proliferation and Survival, 2014-09-23

• In vivo dissection of chamber selective enhancers reveals estrogen-related receptor as a regulator of ventricular cardiomyocyte identity, 2023-01-27

• De novocardiomyocytes from within the activated adult heart after injury, 2011-06-08

• Optimization of Genome Engineering Approaches with the CRISPR/Cas9 System, 2014-08-28

• SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth, 2015-09-22

• Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth, 2016-10-06

• Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre Alleles, 2012-11-09

• Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta, 2020-02-24

• Editing the trajectory of hypertrophic cardiomyopathy, 2023-06-16

• Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart, 2011-12-08

• Septum Transversum-Derived Mesothelium Gives Rise to Hepatic Stellate Cells and Perivascular Mesenchymal Cells in Developing Mouse Liver, 2011-02-03

• HCN4 charges up the first heart field, 2013-08-02

• Epicardial epithelial to mesenchymal transition in injured heart, 2011-09-26

• Congenital Heart Disease-Causing Gata4 Mutation Displays Functional DeficitsIn Vivo, 2012-05-10

• Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin, 2011-12-02

• Myocardial Regeneration: Expanding the Repertoire of Thymosin ß4 in the Ischaemic Heart, 2014-06-04

• Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor, 2018-09-21

• Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation, 2021-07-21

• Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome, 2022-10-05

• Yap1modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload, 2022-10-03

• CMYA5 establishes cardiac dyad architecture and positioning, 2022-04-21

• Synergistic Effects of the GATA-4-Mediated miR-144/451 Cluster in Protection against Simulated Ischemia/Reperfusion-Induced Cardiomyocyte Death, 2010-08-11

• Divergent Requirements for EZH1 in Heart Development Versus Regeneration, 2017-05-16

• Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction, 2015-09-21

• Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction, 2013-09-08

• An IGF1R-dependent pathway drives epicardial adipose tissue formation after myocardial injury, 2016-11-01

• A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers, 2019-10-28

• Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells, 2012-04-18

• Peritruncal Coronary Endothelial Cells Contribute to Proximal Coronary Artery Stems and Their Aortic Orifices in the Mouse Heart, 2013-11-21

• Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association with Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis, 2022-05-10

• Efficientin vivohomology-directed repair within cardiomyocytes, 2022-03-07

• ACTN2Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes, 2022-09-02

• aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model, 2019-12-16

• Cardiac ISL1-Interacting Protein, a Cardioprotective Factor, Inhibits the Transition From Cardiac Hypertrophy to Heart Failure, 2022-03-17

• Hippo Activation in Arrhythmogenic Cardiomyopathy, 2014-01-31

• Introduction to the Special Issue on Heart Regeneration and Rejuvenation, 2014-10-12

• Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis, 2017-04-13

• Identification of a hybrid myocardial zone in the mammalian heart after birth, 2017-07-20

• Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development, 2022-09-10

• Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes, 2016-12-03

• YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes, 2021-06-22

• Harnessing Hippo in the heart: Hippo/YAP1 signaling and applications to heart regeneration and rejuvenation, 2014-05-06

• Reassessment ofIsl1andNkx2-5cardiac fate maps using aGata4-based reporter of Cre activity, 2008-08-22

• Cellular Origin and Developmental Program of Coronary Angiogenesis, 2015-01-30

• Recounting cardiac cellular composition, 2016-02-05

• Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation, 2017-10-11

• Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies, 2014-05-11

• Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium, 2008-08-21

• Increased ROS-mediated CaMKII activation contributes to calcium handling abnormalities and impaired contraction in Barth syndrome, 2021-04-01

• Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model, 2014-05-15

• WT1 regulates epicardial epithelial to mesenchymal transition through ß-catenin and retinoic acid signaling pathways, 2011-05-30

• Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes, 2011-08-26

• Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks, 2017-06-13

• Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart, 2020-09-16

• Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts, 2021-07-14

• PDGFRß signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations, 2008-10-23

• Genetic Fate Mapping Demonstrates Contribution of Epicardium-Derived Cells to the Annulus Fibrosis of the Mammalian Heart, 2009-12-16

• Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy, 2023-08-17

• Genome-wide Location Analysis by Pull Down of in vivo Biotinylated Transcription Factors, 2010-11-02

• Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase, 2015-05-29

• Genetic mosaics for greater precision in cardiovascular research, 2018-06-22

• Analysis of Cardiac Myocyte Maturation Using CASAAV, A Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo, 2017-03-29

• Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis, 2020-01-30