Dr. Theodore Lawrence, MD

• Medical Oncology

• Internal Medicine

• Radiation Oncology

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• Cornell University / New York State Statutory Colleges

  Medical School, 1980

• Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: A review, 2008-11-01

• Clinical Development of Novel Drug-Radiotherapy Combinations, 2018-11-29

• Abdominal synthetic CT generation from MR Dixon images using a U-net trained with ‘semi-synthetic' CT data, 2020-06-15

• Comparison of Stereotactic Body Radiation Therapy and Radiofrequency Ablation in the Treatment of Intrahepatic Metastases, 2017-12-15

• Personalized dose selection in radiation therapy using statistical models for toxicity and efficacy with dose and biomarkers as covariates, 2014-08-27

• EGFR Targeted Therapies and Radiation: Optimizing Efficacy by Appropriate Drug Scheduling and Patient Selection, 2015-07-21

• Tristetraprolin Mediates Radiation-Induced TNF-a Production in Lung Macrophages, 2013-02-28

• Quantification of liver function by linearization of a 2-compartment model of gadoxetic-acid uptake using dynamic contrast enhanced magnetic resonance imaging, 2018-04-19

• Prediction of Liver Function by Using Magnetic Resonance-based Portal Venous Perfusion Imaging, 2012-04-18

• Moving Beyond the Standard of Care: Accelerate Testing of Radiation-Drug Combinations, 2021-08-25

• A Situational Awareness Bayesian Network Approach for Accurate and Credible Personalized Adaptive Radiotherapy Outcomes Prediction in Lung Cancer Patients, 2021-06-04

• FBXW7 facilitates non-homologous end-joining via K63-linked polyubiquitylation of XRCC4, 2016-01-07

• Quantitative Characterizations of Ultrashort Echo (UTE) Images for Supporting Air-Bone Separation in the Head, 2015-03-17

• A human-in-the-loop based Bayesian network approach to improve imbalanced radiation outcomes prediction for hepatocellular cancer patients with stereotactic body radiotherapy, 2022-12-09

• Randomized Phase II study of Physiologic MRI-directed Adaptive Radiation Boost in Poor Prognosis Head and Neck Cancer, 2022-12-01

• Tumor-Reprogrammed Stromal BCAT1 Fuels Branched Chain Ketoacid Dependency in Stromal-Rich PDAC Tumors, 2020-07-06

• Arterial Perfusion Imaging-Defined Subvolume of Intrahepatic Cancer, 2014-03-07

• Prognostic Value of c-MET Expression in Patients With Pancreatic Cancer Receiving Adjuvant and Neoadjuvant Chemoradiation Therapy, 2017-10-28

• Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors, 2016-09-06

• The Parametric Response Map: An Imaging Biomarker for Early Cancer Treatment Outcome, 2009-04-19

• Response-driven Imaging Biomarkers for Predicting Radiation Necrosis of the Brain, 2014-04-28

• Lower Incidence of Esophagitis in the Elderly Undergoing Definitive Radiation Therapy for Lung Cancer, 2017-02-01

• Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases, 2011-01-31

• Radiation-Induced Lung Toxicity in Non-Small-Cell Lung Cancer: Understanding the Interactions of Clinical Factors and Cytokines with the Dose-Toxicity Relationship, 2017-09-23

• A Local and Global Function Model of the Liver, 2015-10-09

• Advances in MR and PET imaging: Assessing Response in the Treatment of Low Grade Glioma, 2015-02-21

• Stereotactic body radiation therapy (SBRT) following Yttrium-90 (90Y) selective internal radiation therapy (SIRT): a feasibility planning study using90Y delivered dose, 2023-03-10

• The combination of EGFR inhibitors with gemcitabine and radiation in pancreatic cancer, 2008-08-15

• Screening and Validation of Molecular Targeted Radiosensitizers, 2021-07-31

• Greater Reduction in Mid-treatment FDG-PET Volume May Be Associated with Worse Survival in Non-Small Cell Lung Cancer, 2018-10-30

• Utility based approach in individualized optimal dose selection using machine learning methods, 2022-03-28

• Phase I Trial of Dose-Escalated Whole Liver Irradiation with Hepatic Arterial Fluorodeoxyuridine/Leucovorin and Streptozotocin Followed by Fluorodeoxyuridine/Leucovorin and Chemoembolization for Patients with Neuroendocrine Hepatic Metastases, 2016-01-22

• Involvement of p38-ßTrCP-Tristetraprolin-TNFa axis in radiation pneumonitis, 2017-05-10

• Expression of the of the androgen receptor governs radiation resistance in a subset of glioblastomas vulnerable to anti-androgen therapy, 2020-08-12

• Use a survival model to correlate single-nucleotide polymorphisms of DNA repair genes with radiation dose response in patients with non-small cell lung cancer, 2015-08-04

• Prognostic Significance of Carbohydrate Antigen 19-9 in Unresectable Locally Advanced Pancreatic Cancer Treated With Dose-Escalated Intensity Modulated Radiation Therapy and Concurrent Full-Dose Gemcitabine: Analysis of a Prospective Phase 1/2 Dose Escalation Study, 2012-12-19

• Long term outcomes of Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular Cancer (HCC) without Macrovascular Invasion, 2020-05-24

• Assessing the dosimetric accuracy of MR-generated synthetic CT images for focal brain VMAT radiotherapy, 2015-09-04

• Gemcitabine Plus Radiation Therapy for High Grade Glioma: Long-term Results of a Phase I Dose-Escalation Study, 2015-11-10

• A Deep Survival Interpretable Radiomics Model of Hepatocellular Carcinoma Patients, 2021-03-10

• Imaging Findings Within the First 12 Months of Hepatocellular Carcinoma Treated With Stereotactic Body Radiation Therapy, 2017-08-24

• Prospective analysis of parametric MRI biomarkers: Identification of early and distinct glioma response patterns not predicted by standard radiographic assessment, 2011-04-28

• Phase 2 Trial of Neoadjuvant FOLFIRINOX and Intensity Modulated Radiation Therapy Concurrent With Fixed-Dose Rate-Gemcitabine in Patients With Borderline Resectable Pancreatic Cancer, 2019-09-05

• Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor, 2011-11-09

• Survival Prediction Analysis in Glioblastoma With Diffusion Kurtosis Imaging, 2021-07-14

• Physiological Imaging-Defined Response-Driven Subvolumes of a Tumor, 2012-12-17

• Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination, 2021-01-04

• Maternal Embryonic Leucine Zipper Kinase (MELK) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer, 2016-05-25

• Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy, 2017-03-08

• The Role of Cell Cycle in Epidermal Growth Factor Receptor Inhibitor-Mediated Radiosensitization, 2009-06-09

• Isoforms of RNF128 Regulate the Stability of Mutant P53 in Barrett's Esophageal Cells, 2019-11-09

• A hierarchical model of abdominal configuration changes extracted from golden angle radial magnetic resonance imaging, 2021-02-09

• A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB, 2009-11-06

• Using Indocyanine Green Extraction to Predict Liver Function After Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma, 2017-09-22

• Radiation produces differential changes in cytokine profiles in radiation lung fibrosis sensitive and resistant mice, 2009-02-02

• Regional Variation in Brain White Matter Diffusion Index Changes following Chemoradiotherapy: A Prospective Study Using Tract-Based Spatial Statistics, 2013-03-04

• A Phase I clinical and pharmacology study using amifostine as a radioprotector in dose-escalated whole liver radiation therapy, 2012-03-21

• A Phase II Study of Dose-Intensified Chemoradiation Using Biologically-Based Target Volume Definition in Patients with Newly Diagnosed Glioblastoma, 2021-01-29

• Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors, 2016-07-11

• A Multi-Institutional Phase II Study of Neoadjuvant Gemcitabine and Oxaliplatin with Radiation Therapy in Patients with Pancreatic Cancer, 2013-05-29

• Predictive Values of MRI and PET Derived Quantitative Parameters for Patterns of Failure in Both p16+ and p16- High Risk Head and Neck Cancer, 2019-11-14

• A Bayesian Dose-finding Design for Outcomes Evaluated with Uncertainty, 2021-04-22

• Serum microRNA Signature Predicts Response to High-dose Radiotherapy in Locally Advanced Non-Small-Cell Lung Cancer, 2017-09-04

• Circulating MicroRNAs as Biomarkers of Radiation-Induced Cardiac Toxicity in Non-Small Cell Lung Cancer, 2019-03-28

• Purine metabolism regulates DNA repair and therapy resistance in glioblastoma, 2020-07-30

• Stereotactic Body Radiation Therapy as an Alternative to Transarterial Chemoembolization for Hepatocellular Carcinoma, 2017-09-14

• Genetic Variations in TGFß1, tPA and ACE and Radiation-induced Thoracic Toxicities in Patients with Non-Small Cell Lung Cancer, 2013-04-22

• A radiation-induced hippocampal vascular injury surrogate marker predicts late neurocognitive dysfunction, 2015-08-08

• Predictive Models for Regional Hepatic Function Based upon 99mTc-IDA SPECT and Local Radiation Dose for Physiological Adaptive RT, 2013-05-18

• Association of11C-Methionine PET uptake with site of failure after concurrent temozolomide and radiation for primary glioblastoma multiforme, 2008-10-01

• Utility based approach in individualized optimal dose selection using machine learning methods Utility based approach in individualized optimal dose selection using machine learning methods, 2022-03-28

• The effect of erlotinib on EGFR and downstream signaling in oral cavity squamous cell carcinoma, 2012-08-21

• Glioblastoma Therapy Can be Augmented by Targeting IDH1-mediated NADPH Biosynthesis, 2016-12-06

• Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma, 2019-09-01

• DW-MRI as a Biomarker to Compare Therapeutic Outcomes in Radiotherapy Regimens Incorporating Temozolomide or Gemcitabine in Glioblastoma, 2012-04-20

• Modeling intra-fractional abdominal configuration changes using breathing motion-corrected radial MRI, 2021-04-12

• MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells, 2009-08-28

• Molecular Imaging of N-linked Glycosylation Suggests Glycan Biosynthesis is a Novel Target for Cancer Therapy, 2010-04-22

• A clinical decision support system for AI-assisted decision-making in response-adaptive radiotherapy (ARCliDS), 2023-03-31

• Implementing Radiation Dose-Volume Liver Response in Biomechanical Deformable Image Registration, 2017-06-27

• Volumetric prediction of breathing and slow drifting motion in the abdomen using radial MRI and multi-temporal resolution modeling, 2021-09-03

• Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer, 2017-08-18