Dr. Ted Dawson Jr, MD

• Neurology

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• Hospital University Pa

  Residency Hospital

• University Ut

  Internship Hospital

• The Johns Hopkins Hospital

  Fellowship Hospital, 1993

• Johns Hopkins University

  Fellowship Hospital, 1992

• University Of Utah School Of Medicine

  Medical School, 1986

• APDM gait and balance measures fail to predict symptom progression rate in Parkinson's disease, 2022-11-09

• PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency, 2020-03-05

• Cognitive impairment in Parkinson's disease: association between patient-reported and clinically measured outcomes, 2016-09-27

• Development of a novel method for the quantification of tyrosine 39 phosphorylated a- and ß-synuclein in human cerebrospinal fluid, 2020-05-04

• Parthanatos, a messenger of death, 2009-01-01

• LRRK2 G2019S Transgenic Mice Display Increased Susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Mediated Neurotoxicity, 2016-01-22

• Gait function and locus coeruleus Lewy body pathology in 51 Parkinson's disease patients, 2016-09-25

• Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration ina-Synuclein-Based Mouse Models of Parkinson's Disease, 2021-06-01

• The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity, 2017-04-24

• Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1, 2016-06-07

• Parkin Protects Against LRRK2 G2019S Mutant-induced Dopaminergic Neurodegeneration inDrosophila, 2009-09-09

• PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease, 2020-03-13

• Resistance to MPTP-Neurotoxicity in a-Synuclein Knockout Mice Is Complemented by Human a-Synuclein and Associated with Increased ß-Synuclein and Akt Activation, 2011-01-31

• Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease, 2009-10-20

• Two approaches reveal a new paradigm of ‘switchable or genetics-influenced allele-specific DNA methylation' with potential in human disease, 2017-11-14

• Botch is a ?-glutamyl Cyclotransferase that Deglycinates and Antagonizes Notch, 2014-04-24

• Adult Conditional Knockout of PGC-1a Leads to Loss of Dopamine Neurons, 2016-09-02

• Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes, 2017-04-23

• Models of LRRK2 associated Parkinson's disease, 2017-05-16

• PARIS (ZNF746) Repression of PGC-1a Contributes to Neurodegeneration in Parkinson's Disease, 2011-03-04

• Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration, 2018-02-13

• LRRK2 Pathobiology in Parkinson's Disease, 2014-10-10

• Cognitive Profile ofLRRK2-related Parkinson's Disease, 2015-02-04

• Poly (ADP-ribose) Drives Pathologic a-Synuclein Neurodegeneration in Parkinson's Disease., 2018-11-02

• a-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism, 2018-01-08

• Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease, 2021-04-26

• Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins, 2022-09-14

• Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson's disease, 2009-07-17

• ADP-ribosyltransferases, an update on function and nomenclature, 2021-09-13

• Semantic fluency and processing speed are reduced in non-cognitively impaired participants with Parkinson's disease, 2021-08-06

• AIF3 splicing switch triggers neurodegeneration, 2021-04-14

• Linked Clinical Trials - The Development of New Clinical Learning Studies in Parkinson's Disease Using Screening of Multiple Prospective New Treatments, 2013-01-01

• Leucine-rich Repeat Kinase 2 Expression Leads to Aggresome Formation that is not Associated with a-Synuclein Inclusions, 2009-07-15

• Integrative genome-wide analysis of dopaminergic neuron-specific PARIS expression inDrosophiladissects recognition of multiple PPAR-? associated gene regulation, 2021-11-02

• TRIP12 Ubiquitination of Glucocerebrosidase Contributes to Neurodegeneration in Parkinson's Disease, 2021-10-12

• Pharmacologic inhibition of MIF nuclease: A new treatment paradigm to treat cell death, 2022-09-20

• MiR-223 regulates the differentiation of immature neurons, 2014-06-17

• Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons, 2011-08-10

• AMPA Receptor Surface Expression Is Regulated byS-Nitrosylation of Thorase and Transnitrosylation of NSF, 2020-11-03

• Functional Identification of Neuroprotective Molecules, 2010-11-24

• Unexpected Lack of Hypersensitivity in LRRK2 Knock-out Mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 2009-12-16

• Neuronal Activity Regulates Hippocampal miRNA Expression, 2011-10-03

• Motor neuron death in ALS - programmed by astrocytes?, 2014-03-05

• Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease Wang et al, 2022-05-06

• Parkinson's Disease Shares the Lysosome with Gaucher's Disease, 2011-07-13

• Markers of Impaired Motor and Cognitive Volition in Parkinson's Disease: Correlates of Dopamine Dysregulation Syndrome, Impulse Control Disorder, and Dyskinesias, 2017-11-21

• Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity, 2016-04-06

• LRRK2 GTPase Dysfunction in the Pathogenesis of Parkinson's disease, 2013-06-13

• C9orf72Hexanucleotide Repeat Analysis in Cases with Pathologically Confirmed Dementia with Lewy Bodies, 2016-05-31

• The Impact of Genetic Research on Our Understanding of Parkinson's Disease, 2015-05-27

• Mass spectrometry-based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways, 2022-11-10

• Microglia and Astrocyte Dysfunction in Parkinson's Disease, 2020-07-28

• Mass Spectrometry-Based Proteomics Analysis of Human Substantia Nigra From Parkinson's Disease Patients Identifies Multiple Pathways Potentially Involved in the Disease, 2022-11-22

• Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa, 2021-06-29

• Conditional transgenic mice expressing C-terminally truncated human a-synuclein (aSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons, 2009-07-24

• Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research, 2012-08-27

• Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and a-Synuclein Pathology, 2017-03-17

• Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia, 2010-03-04

• Understanding microRNAs in Neurodegeneration, 2009-11-11

• Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease, 2022-05-06

• Parthanatos Mediates AIMP2 Activated Age Dependent Dopaminergic Neuronal Loss, 2013-08-25

• Sulfhydration mediates neuroprotective actions of parkin, 2013-03-18

• GBAvariants are associated with a distinct pattern of cognitive deficits in Parkinson disease, 2015-08-21

• Transneuronal Propagation of Pathologic a-Synuclein from the Gut to the Brain Models Parkinson's disease, 2019-06-26

• Poly (ADP-ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical For PAR Polymerase-1-Dependent Cell Death (Parthanatos), 2011-04-05

• Development and characterization of a new Parkinson disease model resulting from impaired autophagy, 2012-11-14

• AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1, 2022-08-17

• Iduna Protects the Brain from Glutamate Excitotoxicity and Stroke by Interfering with Parthanatos, 2011-05-22

• Myoclonus-dystonia and Silver-Russell syndrome resulting from maternal uniparental disomy of chromosome 7, 2013-01-20

• MicroRNAs in Parkinson's Disease, 2011-02-02

• Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease A Randomized Clinical Trial Nilotinib in Patients With Moderately Advanced Parkinson Disease, 2020-12-14

• Lysosomal Enzyme Glucocerebrosidase Protects against Aß1-42Oligomer-Induced Neurotoxicity, 2015-12-02

• Ironing out Tau's Role in Parkinsonism, 2012-02-06

• Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder, 2014-09-15

• The NINDS Parkinson's Disease Biomarkers Program, 2015-10-07

• High-Content Genome-Wide RNAi Screen RevealsCCR3as a Key Mediator of Neuronal Cell Death, 2016-10-24

• Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain, 2023-01-10

• Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models, 2020-07-14

• Targeting Parthanatos in Ischemic Stroke, 2021-05-05

• CALPAIN ACTIVATION IS NOT REQUIRED FOR AIF TRANSLOCATION IN PARP-1-DEPENDENT CELL DEATH (PARTHANATOS), 2009-05-13

• Neurons Derived from Human Induced Pluripotent Stem Cells Integrate into Rat Brain Circuits and Maintain Both Excitatory and Inhibitory Synaptic Activities, 2019-08-22

• Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis, 2017-05-16

• The interplay of microRNA and neuronal activity in health and disease, 2013-08-27

• Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease, 2018-06-11

• LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8, 2021-01-20

• Conditional Expression of Parkinson's Disease-Related R1441C LRRK2 in Midbrain Dopaminergic Neurons of Mice Causes Nuclear Abnormalities without Neurodegeneration, 2014-08-29

• GENETIC ANALYSIS OF NEURODEGENERATIVE DISEASES IN A PATHOLOGY COHORT, 2018-11-17

• Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease, 2018-02-09

• Botch (NPG7) Promotes Neurogenesis by Antagonizing Notch, 2012-03-22

• Assessment of APOE in Atypical Parkinsonism Syndromes, 2019-02-21

• Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains, 2021-11-30

• Lymphocyte Activation Gene 3 (Lag3) Contributes to a-Synucleinopathy in a-Synuclein Transgenic Mice, 2021-03-10

• Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson's Disease, 2010-08-22

• The AAA+ATPase, Thorase Regulates AMPA Receptor-Dependent Synaptic Plasticity and Behavior, 2011-04-15

• Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture, 2021-02-15

• Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease, 2014-04-10

• Reprogramming cellular events by poly(ADP-ribose)-binding proteins, 2012-12-23

• New Synaptic and Molecular Targets for Neuroprotection in Parkinson's Disease, 2012-08-23

• LRRK2 Affects Vesicle Trafficking, Neurotransmitter Extracellular Level and Membrane Receptor Localization, 2013-10-22

• Animal Models of Neurodegenerative Diseases, 2018-09-24

• The A1 astrocyte paradigm: New avenues for pharmacologic intervention in neurodegeneration, 2019-05-28

• Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological a-synuclein, 2022-02-15

• Dynamic and redundant regulation of LRRK2 and LRRK1 expression, 2007-11-28

• Parkin and PINK1: Much More than Mitophagy, 2014-04-13

• What causes cell death in Parkinson's Disease?, 2014-06-24

• Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's Disease, 2022-06-01

• Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis, 2019-07-31

• Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2, 2011-04-06

• Genetic Animal Models of Parkinson's Disease, 2010-06-10

• Meta-analysis of Parkinson disease: Identification of a novel locus,RIT2, 2011-12-02

• PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease, 2022-05-10

• Early-onset Parkinson's disease due toPINK1p.Q456X mutation - clinical and functional study, 2014-09-02

• ArfGAP1 is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2, 2012-03-14

• PINK1 primes parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival, 2017-01-24

• Recent advances in preventing neurodegenerative diseases, 2021-12-01

• T cells of Parkinson's disease patients recognize a-synuclein peptides, 2017-06-21

• PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease, 2021-07-28

• Mitochondrial and Nuclear Cross Talk in Cell Death: Parthanatos, 2015-05-26

• Parkin Plays a Role in Sporadic Parkinson's Disease, 2013-09-11

• Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies, 2016-06-14

• Quantitative mass spectrometric analysis of the mouse cerebral cortex after ischemic stroke, 2020-04-21

• Mitochondrial Stasis Reveals p62-mediated Ubiquitination in Parkin-independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease, 2018-07-12

• DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders, 2018-04-12

• Defects in mRNA translation in LRRK2-mutant hiPSC-derived dopaminergic neurons leads to dysregulated calcium homeostasis, 2020-08-25

• Poly(ADP-ribose) Signals to Mitochondrial AIF: A Key Event in Parthanatos, 2009-03-28

• Pathological a-synuclein transmission initiated by binding lymphocyte-activation gene 3, 2016-09-30

• Leucine rich repeat kinase 2 (LRRK2) as a potential therapeutic target for Parkinson's disease, 2012-05-09

• A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1, 2016-10-07

• Neurotoxic reactive astrocytes are induced by activated microglia, 2017-01-18

• GTPase Activity Plays a Key Role in the Pathobiology of LRRK2, 2010-04-08

• The Role of Parkin in Familial and Sporadic Parkinson's Disease, 2014-06-24

• Recent Advances in the Genetics of Parkinson's Disease, 2014-06-24

• MicroRNA-132 dysregulation inToxoplasma gondiiinfection has implications for dopamine signaling pathway, 2014-03-18

• Amelioration of pathologic a-synuclein-induced Parkinson's disease by irisin, 2022-08-31