Dr. Steven Lubitz, MD

• Cardiology

• Clinical Cardiac Electrophysiology

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• University Of Michigan / Medical Center

  Medical School, 2002

• Age of Natural Menopause and Atrial Fibrillation: the Framingham Heart Study, 2012-03-29

• A Twelve-SNP Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke, 2014-08-14

• Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways, 2022-09-01

• Copy number variation and warfarin dosing: evaluation ofCYP2C9, VKORC1, CYP4F2, GGCXandCALU, 2011-12-21

• Monogenic and Polygenic Contributions to QTc Prolongation in the Population, 2022-04-07

• Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registry, 2021-04-28

• Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation, 2017-04-17

• Exercise Interventions in Patients with Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy: A Systematic Review and Meta-Analysis, 2018-09-21

• A Novel Clinical Prediction Rule for 30-day Mortality Following Balloon Aortic Valuloplasty: The CRRAC the AV Score, 2011-03-16

• Validation of Polygenic Scores for QT Interval in Clinical Populations, 2017-09-13

• Detection of Atrial Fibrillation in a Large Population using Wearable Devices: the Fitbit Heart Study, 2022-09-23

• Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes, 2022-08-30

• Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations, 2018-08-13

• Personalized medicine and atrial fibrillation: will it ever happen?, 2012-12-04

• Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results from a National Biobank, 2019-11-06

• Common Variants inKCNN3are Associated with Lone Atrial Fibrillation, 2010-02-21

• Electrocardiogram-based Deep Learning and Clinical Risk Factors to Predict Atrial Fibrillation, 2021-11-08

• Deep Learning to Predict Cardiac Magnetic Resonance-Derived Left Ventricular Mass and Hypertrophy from 12-Lead Electrocardiograms, 2021-06-15

• Genome Wide Association Studies in Cardiac Electrophysiology: Recent Discoveries and Implications for Clinical Practice, 2010-04-25

• PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity, 2018-07-25

• Screening for undiagnosed atrial fibrillation using a single-lead electrocardiogram at primary care visits: patient uptake and practitioner perspectives from the VITAL-AF trial, 2023-06-30

• Common Coding Variants inSCN10Aare associated with the Nav1.8 Late Current and Cardiac Conduction, 2019-01-29

• Cost-effectiveness of Screening for Atrial Fibrillation Using Wearable Devices Cost-effectiveness of Atrial Fibrillation Screening With Wearable Devices, 2022-08-05

• Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (From the Framingham Heart Study), 2016-08-24

• Clinical and Genetic Evaluation After Sudden Cardiac Arrest, 2020-01-15

• Genetic analysis of right heart structure and function in 40,000 people, 2022-06-13

• Variants inZFHX3are associated with atrial fibrillation in individuals of European ancestry, 2009-07-13

• White Blood Cell Count and Risk of Incident Atrial Fibrillation (From the Framingham Heart Study), 2011-11-17

• Rare and low-frequency coding variants alter human adult height, 2017-02-01

• Predictive Accuracy of a Clinical and Genetic Risk Model for Atrial Fibrillation, 2021-08-31

• Whole genome sequence analysis of blood lipid levels in >66,000 individuals, 2022-10-11

• Whole Blood Gene Expression and Atrial Fibrillation: The Framingham Heart Study, 2014-05-07

• Integrative Omics Approach to Identifying Genes Associated with Atrial Fibrillation, 2019-12-05

• Association between Familial Atrial Fibrillation and Risk of New-onset Atrial Fibrillation, 2010-11-13

• Discovery of novel heart rate-associated loci using the Exome Chip, 2017-04-03

• Genetic loci associated with heart rate variability and their effects on cardiac disease risk, 2017-06-14

• Massachusetts general hospital Covid-19 registry reveals two distinct populations of hospitalized patients by race and ethnicity, 2020-12-22

• Emerging role of artificial intelligence in cardiac electrophysiology, 2022-09-27

• Development and Validation of a Prediction Model for Atrial Fibrillation Using Electronic Health Records, 2019-10-02

• TRAJECTORIES OF RISK FACTORS AND RISK OF NEW-ONSET ATRIAL FIBRILLATION IN THE FRAMINGHAM HEART STUDY, 2016-07-11

• Stroke Prevention in Atrial Fibrillation in Older Adults: Existing Knowledge Gaps and Areas for InnovationA Summary of an American Federation of Aging Research Seminar, 2013-09-19

• Development of a clinical polygenic risk score assay and reporting workflow, 2022-04-18

• Whole Exome Sequencing in Atrial Fibrillation, 2016-09-02

• Large-Scale Candidate Gene Analysis in Whites and African-Americans IdentifiesIL6RPolymorphism in Relation to Atrial Fibrillation: The NHLBI CARe Project, 2011-08-16

• Next Generation Sequencing for the Diagnosis of Cardiac Arrhythmia Syndromes, 2015-01-24

• Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations, 2019-12-23

• Cross-modal autoencoder framework learns holistic representations of cardiovascular state, 2023-04-28

• Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery, 2018-11-11

• Symptoms and Functional Status of Patients with Atrial Fibrillation: State-of-the-Art and Future Research Opportunities, 2012-06-12

• Prediction performance and fairness heterogeneity in cardiovascular risk models, 2022-07-22

• Wearing Your Heart on Your Sleeve: the Future of Cardiac Rhythm Monitoring, 2019-11-25

• Relation of Orthostatic Hypotension with New-Onset Atrial Fibrillation (From the Framingham Heart Study), 2017-12-11

• Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy, 2020-05-07

• Genetic Link Between Arterial Stiffness and Atrial Fibrillation, 2019-06-18

• Genetically Determined Birthweight Associates with Atrial Fibrillation: A Mendelian Randomization Study, 2020-04-27

• Performance of Atrial Fibrillation Risk Prediction Models in Over Four Million Individuals, 2020-12-09

• Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation, 2018-06-11

• Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes, 2022-09-30

• Catheter Ablation for Brugada Syndrome, 2021-05-15

• Population-based Screening for Atrial Fibrillation, 2020-06-18

• Reciprocal Relations between Physical Disability, Subjective Health, and Atrial Fibrillation: The Framingham Heart Study, 2013-04-30

• Protein Biomarkers and Risk of Atrial Fibrillation: The Framingham Heart Study, 2020-01-15

• Deep learning enables genetic analysis of the human thoracic aorta, 2021-11-26

• The Effect of PCSK9 Inhibition on the Risk of Venous Thromboembolism, 2020-03-29

• Atrial fibrillation: Current knowledge and future directions in epidemiology and genomics, 2011-11-01

• Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms, 2017-05-03

• Genome-wide association analyses identify novel Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility, 2022-02-24

• Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study, 2017-01-09

• Initial Precipitants and Recurrence of Atrial Fibrillation, 2020-02-12

• Long-Term Outcomes of Secondary Atrial Fibrillation in the Community: The Framingham Heart Study, 2015-03-13

• Atrial Fibrillation in Congestive Heart Failure, 2010-06-07

• Novel Genetic Markers Associate with Atrial Fibrillation Risk in Europeans and Japanese, 2014-01-30

• The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations, 2022-05-03

• Serum Brain-derived Neurotrophic Factor and Risk of Atrial Fibrillation, 2016-10-17

• New-onset Atrial Fibrillation during Hospitalization, 2014-12-01

• Stroke as the Initial Manifestation of Atrial Fibrillation: the Framingham Heart Study, 2017-01-12

• Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease, 2020-06-09

• Genetic Burden ofTNNI3Kin Diagnostic Testing of Patients With Dilated Cardiomyopathy and Supraventricular Arrhythmias, 2023-05-18

• Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval, 2018-03-29

• P Wave Duration and Risk of Longitudinal Atrial Fibrillation Risk in Persons =60 Years Old (from the Framingham Heart Study), 2011-01-20

• Effect ofCYP4F2,VKORC1, andCYP2C9in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals, 2019-02-17

• Research Priorities in Atrial Fibrillation Screening: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop, 2021-01-25

• Management of Congenital Long QT Syndrome: Commentary from the Experts, 2021-07-09

• Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices, 2021-04-12

• Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium, 2017-09-12

• Low Serum Magnesium and the Development of Atrial Fibrillation in the Community: The Framingham Heart Study, 2012-11-21

• Elevation of Parathyroid Hormone Levels in Atrial Fibrillation, 2011-06-21

• A comparison of the CHARGE-AF and the CHA2DS2-VASc risk scores for prediction of atrial fibrillation in the Framingham Heart Study, 2016-05-17

• Atrial Fibrillation Risk and Discrimination of Cardioembolic from Noncardioembolic Stroke, 2020-04-07

• Assessing the contribution of rare variants to complex trait heritability from whole genome sequence data, 2022-03-07

• Temporal trends in cause-specific mortality among individuals with newly diagnosed atrial fibrillation in the Framingham Heart Study, 2021-07-29

• Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease, 2020-12-18

• Subclinical atrial fibrillation detection with a floating atrial sensing dipole in single lead implantable cardioverter-defibrillator systems: Results of the SENSE trial, 2019-08-05

• Automated Electronic Phenotyping of Cardioembolic Stroke, 2020-12-10

• Integrating Genetic, Transcriptional, and Functional Analyses to Identify Five Novel Genes for Atrial Fibrillation, 2014-08-14

• Heritability of Atrial Fibrillation, 2017-11-02

• ExomeChip-Wide Analysis of 95,626 Individuals Identifies 10 Novel Loci Associated with QT and JT Intervals, 2017-11-28

• Trends in Consumer Wearable Devices with Cardiac Sensors in a Primary Care Cohort, 2022-06-27

• Early-Onset Atrial Fibrillation and the Prevalence of Rare Variants in Cardiomyopathy and Arrhythmia Genes Early-Onset Atrial Fibrillation and Rare Variant Prevalence in Cardiomyopathy and Arrhythmia Genes, 2021-09-08

• Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study, 2020-08-19

• Atrial Fibrillation Begets Heart Failure and Vice Versa: Temporal Associations and Differences in Preserved vs. Reduced Ejection Fraction, 2016-01-08

• Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction, 2020-05-21

• Plasma resistin, adiponectin, and risk of incident atrial fibrillation: The Framingham Offspring Study, 2011-11-17

• Association between titin loss-of-function variants and early-onset atrial fibrillation, 2018-12-11

• Independent Susceptibility Markers for Atrial Fibrillation on Chromosome 4q25, 2010-08-23

• Vitamin D Status is Not Related to Development of Atrial Fibrillation in the Community, 2011-08-11

• Identifying high risk clinical phenogroups of pulmonary hypertension through a clustering analysis, 2023-08-25

• Titin truncating variants in adults without known congestive heart failure, 2020-03-17

• Gene-gene Interaction Analyses for Atrial Fibrillation, 2016-11-08

• Genetic factors influencing warfarin dose in Black-African patients: a systematic review and meta-analysis, 2020-01-28

• European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on arrhythmias and cognitive function: what is the best practice?, 2018-03-18

• Cohort design and natural language processing to reduce bias in electronic health records research, 2022-04-08

• Wearable accelerometer-derived physical activity and incident disease, 2022-09-02

• Galectin 3 and incident atrial fibrillation in the community, 2014-03-01

• Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis, 2016-01-21

• Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank, 2022-02-17

• Common and Rare Variants Associated with Cardiometabolic Traits across 98,622 Whole-Genome Sequences in theAll of UsResearch Program, 2023-04-18

• The role of obesity in inflammatory markers in COVID-19 patients, 2020-12-23

• Response by Lubitz et al. to Letter Regarding Article, "Stroke as the Initial Manifestation of Atrial Fibrillation. The Framingham Heart Study.”, 2017-04-17

• Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes Mortality in Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes, 2022-05-11

• Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation, 2020-11-06

• A Common Connexin-40 Gene Promoter Variant Affects Connexin-40 Expression in Human Atria and Is Associated with Atrial Fibrillation, 2010-11-13

• Simple Risk Model Predicts Incidence of Atrial Fibrillation in a Racially and Geographically Diverse Population: the CHARGE-AF Consortium, 2013-04-24

• Meta-analysis identifies six new susceptibility loci for atrial fibrillation, 2012-04-29

• Atrial flutter - clinical risk factors and adverse outcomes in the Framingham Heart Study, 2015-07-28

• Genetic Risk Score to Identify Risk of Venous Thromboembolism in Patients with Cardiometabolic Disease, 2021-01-12

• Frequency of Cardiac Rhythm Abnormalities in a Half Million Adults, 2018-05-23

• Screening for Atrial Fibrillation in Older Adults at Primary Care Visits: the VITAL-AF Randomized Controlled Trial, 2022-03-02

• DiminishedPRRX1Expression is Associated with Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential, 2017-09-06

• Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass, 2023-03-21

• 2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families, 2020-10-19

• Factors Associated With Anticoagulation Delay Following New-Onset Atrial Fibrillation, 2017-07-24

• Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure, 2020-01-09

• Design and rationale of a pragmatic trial integrating routine screening for atrial fibrillation at primary care visits: The VITAL-AF trial, 2019-06-22

• Genetic Variation in the Alternative Splicing Regulator, RBM20, is associated with Dilated Cardiomyopathy, 2011-10-17

• Response to Letter Regarding Article, "Atrial Fibrillation Begets Heart Failure and Vice Versa: Temporal Associations and Differences in Preserved vs. Reduced Ejection Fraction”, 2016-06-07

• Genome-wide association study of PR interval, 2010-01-10

• Novel Mutation inFLNC(Filamin C) Causes Familial Restrictive Cardiomyopathy, 2017-10-27

• Response to Letter Regarding Article, "Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery”, 2019-07-01

• A Simple and Portable Algorithm for Identifying Atrial Fibrillation in the Electronic Medical Record, 2015-11-06

• Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program, 2021-02-10

• A saturated map of common genetic variants associated with human height, 2022-10-12

• Targeted sequencing in candidate genes for atrial fibrillation: The Cohorts for Heart and Aging Research in Genomic Epidemiology Targeted Sequencing Study, 2013-11-14

• Genetic Risk Prediction of Atrial Fibrillation, 2016-10-28

• Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity, 2017-12-22

• Genetic Obesity and the Risk of Atrial Fibrillation - Causal Estimates from Mendelian Randomization, 2016-12-14

• Epigenetic Age and the Risk of Incident Atrial Fibrillation, 2021-09-30

• Approximate conditional phenotype analysis based on genome wide association summary statistics, 2021-01-28

• Warfarin pharmacogenetic trials: is there a future for pharmacogenetic-guided dosing?, 2014-06-14

• Rare Coding Variants Associated with Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-ancestry Analysis, 2021-07-28

• Sequencing ofSCN5Aidentifies rare and common variants associated with cardiac conduction, 2014-08-26

• Predictors of Oral Anticoagulant Non-prescription in Patients with Atrial Fibrillation and Elevated Stroke Risk, 2018-03-10

• Novel risk modeling approach of atrial fibrillation with restricted mean survival times: application in the Framingham Heart Study community-based cohort, 2020-03-31

• Associations Between Alcohol Intake and Genetic Predisposition with Atrial Fibrillation Risk in a National Biobank, 2020-11-06

• Insulin Resistance and Atrial Fibrillation (From the Framingham Heart Study), 2011-10-12

• Lack of Replication in Polymorphisms Reported to be Associated with Atrial Fibrillation, 2010-11-04

• Systemic Embolic Events (SEE) in Atrial Fibrillation: SEEing Embolic Risk More Clearly, 2015-07-29

• Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation, 2017-11-12