Dr. Stephan Targan, MD

• Gastroenterology

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• Johns Hopkins School Of Medicine

  Medical School, 1971

• The antimicrobial peptide cathelicidin modulatesClostridium difficile-associated colitis and toxin A-mediated enteritis in mice, 2012-07-03

• DistinctIFNGMethylation in a Subset of Ulcerative Colitis Patients Based upon Reactivity to Microbial Antigens, 2011-12-22

• Differential levels of Tl1a affect the expansion and function of regulatory T cells in modulating murine colitis, 2015-10-22

• A role for BATF3 in TH9 differentiation and T cell driven mucosal pathologies, 2019-01-07

• Variants inZNF365isoform D are associated with Crohn's Disease, 2011-01-21

• Combination of Genetic and Quantitative Serological Immune Markers are Associated with Complicated Crohn's Disease Behavior, 2011-03-09

• Genome-wide association identifies multiple ulcerative colitis susceptibility loci, 2010-03-14

• Gene-Microbiota Interactions Contribute to the Pathogenesis of Inflammatory Bowel Disease, 2016-05-05

• Meta-Analysis Increases to 71 the Tally of Confirmed Crohn's Disease Susceptibility Loci, 2012-02-21

• Multi-dimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease, 2013-12-16

• Inflammation independent TL1A-mediated Intestinal Fibrosis is Dependent on the Gut Microbiome, 2018-07-09

• Microbiota activation and regulation of innate and adaptive immunity, 2014-05-07

• IBD-AssociatedTL1AGene (TNFSF15) Haplotypes Determine Increased Expression of TL1A Protein, 2009-03-05

• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47, 2011-02-06

• A pleiotropic missense variant inSLC39A8is associated with Crohn's disease and human gut microbiome composition, 2016-08-01

• BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis, 2022-06-22

• Genetic Variants Synthesize to Produce Paneth Cell Phenotypes that Define Subtypes of Crohn's Disease, 2013-09-25

• TNFRSF1BIs Associated with ANCA in IBD, 2020-05-22

• Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease, 2017-05-04

• Cathelicidin Signaling via the Toll-Like Receptor Protects Against Colitis in Mice, 2011-07-14

• Prevalence and associations of avascular necrosis of the hip in a large well-characterized cohort of patients with inflammatory bowel disease, 2018-03-27

• Microbial Induction of Inflammatory Bowel Disease Associated Gene TL1A (TNFSF15) in Antigen Presenting Cells, 2010-03-09

• Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor, 2016-05-10

• Modeling Intestinal Epithelial Response to Interferon-? in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids, 2020-12-30

• Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo, 2020-10-23

• Epithelial endoplasmic reticulum stress orchestrates a protective IgA response, 2019-03-01

• A Prospective Analysis of Clinical Variables, Serologic Factors and Outcome of Ileal Pouch-Anal Anastomosis in Patients with Backwash Ileitis, 2016-08-19

• Human intestinal epithelial cells express IL-10 through Toll-like receptor 4 (TLR4)-mediated epithelial-macrophage crosstalk, 2014-08-20

• Serologic, Genetic, and Clinical Associations with Increased Healthcare Resource Utilization in IBD, 2018-06-02

• Microbiota-induced TNF-like ligand 1A drives group 3 innate lymphoid cell-mediated barrier protection and intestinal T cell activation during colitis, 2018-12-11

• Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease, 2012-03-09

• Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion, 2022-11-16

• Genetic Predictors of Medically Refractory Ulcerative Colitis, 2010-08-16

• Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis, 2014-05-21

• Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients, 2014-04-15

• SUSTAINED TL1A(TNFSF15)EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS, 2013-04-10

• Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD, 2020-02-20

• TLR8-mediated activation of human monocytes inhibits TL1A expression, 2010-03-09

• Antitumour necrosis factor therapy is associated withde novoCrohn's disease after ileal pouch-anal anastomosis, 2021-07-16

• TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization, 2021-12-31

• Human Natural Killer Cells Licensed by KIR Genes Have an Altered Cytokine Program That Modifies CD4+T Cell Function, 2014-06-16

• Malasseziais Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models, 2019-03-05

• Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis, 2021-06-25

• Markers of intestinal inflammation in patients with ankylosing spondylitis: a pilot study, 2012-11-29

• Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease, 2012-11-01

• Future Therapeutic Approaches for Inflammatory Bowel Diseases, 2016-09-26

• Linkage of CD-related serological phenotypes:NFKB1haplotypes are associated with anti-CBir1 & ASCA, and show reduced NF-?B activation, 2008-10-02

• HMPL-004 (Andrographis paniculataextract) prevents development of murine colitis by inhibiting T cell proliferation and TH1/TH17 responses, 2015-06-01

• Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis, 2011-01-11

• Myeloid ATG16L1 facilitates host-bacteria interactions in maintaining intestinal homeostasis, 2017-01-27

• Combination of Innate and Adaptive Immune Alterations Increased the Likelihood of Fibrostenosis in Crohn's Disease, 2013-11-09

• IFNGrs1861494 Polymorphism is Associated with IBD Disease Severity and Functional Changes in bothIFNGMethylation and Protein Secretion, 2015-02-06

• Perianal Crohn's Disease is associated with distal colonic disease, stricturing disease behavior, IBD-associated serologies and genetic variation in the JAK-STAT pathway, 2016-12-22

• Genome-wide Association Study Identifies African-Specific Susceptibility Loci in African Americans with Inflammatory Bowel Disease, 2016-09-28

• Characterization of Genetic Loci That Affect Susceptibility to Inflammatory Bowel Diseases in African Americans, 2015-08-14