Dr. Scott B Snapper, MD

• Pediatric Gastroenterology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Brigham And Womens Hospital

  Residency Hospital, 1993

• Harvard Med School|harvard Medical School|massachusetts General Hospital

  Fellowship Hospital, 1993

• Brigham And Women's Hospital|brigham And Womens Hospital

  Internship Hospital, 1991

• Albert Einstein College Of Medicine

  Medical School, 1990

• CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor, 2022-01-10

• Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD, 2020-02-06

• Characterization of Adherent Bacteroidales from Intestinal Biopsies of Children and Young Adults with Inflammatory Bowel Disease, 2013-06-11

• Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease, 2020-02-21

• Publisher Correction: Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes, 2021-09-03

• The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment, 2014-06-02

• AHR activation is protective against colitis driven by T cells in humanized mice, 2016-10-25

• STAT1 signaling shields T cells from NK cell-mediated cytotoxicity, 2019-02-22

• Editorial: Inborn errors of immunity and mucosal immunity, 2023-05-09

• Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease, 2022-06-22

• The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis, 2023-03-02

• Haematopoietic stem and progenitor cells from human pluripotent stem cells, 2017-05-17

• Genetic and Structural Analysis of aSKIV2LMutation Causing Tricho-hepato-enteric Syndrome, 2018-02-26

• CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types, 2016-09-29

• Humanized Mouse Models of Genetic Immune Disorders and Hematological Malignancies, 2019-10-18

• Cytotoxic T Lymphocyte Antigen 4 Haploinsufficiency Presenting As Refractory Celiac-Like Disease: Case Report, 2022-07-22

• Very Early-onset Inflammatory Bowel Disease: Gaining Insight Through Focused Discovery, 2018-09-21

• Defects in NADPH Oxidase GenesNOX1andDUOX2in Very Early Onset Inflammatory Bowel Disease, 2015-09-01

• Interleukin 10 Receptor Signaling: Master Regulator of Intestinal Mucosal Homeostasis in Mice and Humans, 2016-01-30

• Gain-of-function variants inSYKcause immune dysregulation and systemic inflammation in humans and mice, 2021-03-29

• Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia, 2021-04-15

• EnterohemorrhagicE. coliRequires N-WASP for Efficient Type III Translocation but Not for EspFU-Mediated Actin Pedestal Formation, 2010-08-19

• Increased Mucosal IL-22 Production of anIL-10RAMutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing, 2017-01-07

• High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue, 2018-08-15

• Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell cycle progression, 2011-09-15

• Mucus sialylation determines intestinal host-commensal homeostasis, 2022-03-17

• A Systematic Review of Monogenic Inflammatory Bowel Disease, 2021-03-18

• INHIBITION OF INFLAMMATORY GENE TRANSCRIPTION BY IL-10 IS ASSOCIATED WITH RAPID SUPPRESSION OF LPS-INDUCED ENHANCER ACTIVATION Suppression of LPS-Induced Enhancer Activation by IL-10, 2017-02-17

• CCL25/CCR9 Interactions Are Not Essential for Colitis Development but Are Required for Innate Immune Cell Protection from Chronic Experimental Murine Colitis, 2018-09-21

• Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation, 2021-11-03

• Colitis and Colon Cancer in WASP-Deficient Mice RequireHelicobacter Spp., 2014-06-10

• A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease, 2017-10-18

• Mucosal Gene Expression in Pediatric and Adult Patients With Ulcerative Colitis Permits Modeling of Ideal Biopsy Collection Strategy for Transcriptomic Analysis, 2018-11-29

• Targeted RNAseq Improves Clinical Diagnosis of Very Early-Onset Pediatric Immune Dysregulation, 2022-06-01

• Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis, 2019-04-01

• Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies, 2015-07-02

• Novel exonic mutation inducing aberrant splicing in theIL10RAgene and resulting in infantile-onset inflammatory bowel disease: a case report, 2016-01-28

• Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells, 2016-07-18

• Vertebral Compression Fractures in Very Early Onset Inflammatory Bowel Disease, 2023-01-19

• Interleukin 1 Beta Mediates Intestinal Inflammation in Mice and Patients with IL10 Receptor Deficiency, 2016-09-28

• Elevated levels of leukotriene C4synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients, 2013-06-07

• Toll-like receptor 4-mediated regulation of spontaneousHelicobacter-dependent colitis in IL-10 deficient mice, 2009-08-03

• N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling, 2013-11-05

• Human TGF-ß1 deficiency causes severe inflammatory bowel disease and encephalopathy, 2018-02-26

• Mutations in Tetratricopeptide Repeat Domain 7A Result in a Severe Form of Very Early Onset Inflammatory Bowel Disease, 2014-01-11

• SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues, 2020-05-28

• Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment, 2012-09-26

• Individual intestinal symbionts induce a distinct population of ROR?+ regulatory T cells, 2015-08-13

• Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort, 2020-12-24

• Variants inTRIM22that Affect NOD2 Signaling Are Associated With Very Early Onset Inflammatory Bowel Disease, 2016-02-04

• Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis, 2018-09-18

• Gut-tropic T Cells that Express Integrin a4ß7 and CCR9 are Required for Induction of Oral Immune Tolerance in Mice, 2011-09-16

• N-WASP Is Required for Structural Integrity of the Blood-Testis Barrier, 2014-06-26

• Spontaneous food allergy inWas-/-mice occurs independent of FceRI-mediated mast cell activation, 2017-07-14

• Children's rare disease cohorts: an integrative research and clinical genomics initiative, 2020-07-06

• The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease, 2014-07-21

• Wiskott-Aldrich Syndrome Protein Deficiency in Innate Immune Cells Leads to Mucosal Immune Dysregulation and Colitis in Mice, 2012-06-15

• Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function, 2014-05-01

• IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes, 2016-11-11

• Activating Mutations of N-WASP AlterShigellaPathogenesis, 2009-04-18

• An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery, 2018-08-13

• NovelCARMIL2loss-of-function variants are associated with pediatric inflammatory bowel disease, 2021-03-15

• Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice, 2017-01-11

• CD55 Deficiency, Early-Onset Protein-Losing Enteropathy and Thrombosis, 2017-06-28

• MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties, 2011-06-06

• Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses, 2022-03-10

• Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Diseases Caused by TTC7A Deficiency, 2019-11-16

• Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease, 2020-05-16

• Breakdown of T cell Tolerance and Autoimmunity in Primary Immunodeficiency - Lessons Learned From Monogenic Disorders in Mice and Men, 2008-11-12

• Clinical Genomics for the Diagnosis of Monogenic Forms of Inflammatory Bowel Disease: A Position Paper From the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition, 2021-03-01

• Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells, 2021-03-22

• Monogenic Inflammatory Bowel Disease: It's Never Too Late to Make a Diagnosis, 2020-09-04

• Intestinal Alkaline Phosphatase Has Beneficial Effects in Mouse Models of Chronic Colitis, 2011-07-28

• Identification of environmental factors that promote intestinal inflammation, 2022-10-20

• IL-10R Polymorphisms are Associated with Very Early-Onset Ulcerative Colitis, 2012-04-10

• WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis, 2018-05-03

• Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis HT Morris et al, 2018-05-28

• Risk-factors Associated with Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review., 2019-02-02

• Protective mucosal immunity mediated by epithelial CD1d and IL-10, 2014-04-06

• Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes, 2021-08-17

• Nuclear Wiskott-Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells, 2017-10-27

• RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing features, 2022-11-18

• Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance, 2012-01-05

• The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution, 2019-03-28

• Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor, 2017-07-05

• The E3 ubiquitin ligase UBR5 interacts with TTC7A and may be associated with very early onset inflammatory bowel disease, 2020-10-29

• Prevalence and Clinical Features of Inflammatory Bowel Diseases Associated with Monogenic Variants, Identified by Whole-exome Sequencing in 1000 Children at a Single Center, 2020-02-19

• Large B-cell lymphoma in an adolescent patient with IL-10 receptor deficiency and history of infantile inflammatory bowel disease, 2015-10-01

• In utero human intestine harbors unique metabolome, including bacterial metabolites, 2020-11-05

• Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications, 2022-11-12