Dr. Ravi Amaravadi, MD

• Medical Oncology

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• Johns Hopkins School Of Medicine

  Medical School

• HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+T-cell infiltration into tumors, 2022-07-14

• HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors, 2016-03-16

• PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer., 2018-11-15

• Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials, 2021-04-15

• ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression, 2019-07-01

• A Randomized Phase II Preoperative Study of Autophagy Inhibition With High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients, 2020-03-10

• Targeting UGCG overcomes resistance to lysosomal autophagy inhibition, 2023-02-06

• Autophagy geneAtg16l1prevents lethal T cell alloreactivity mediated by dendritic cells, 2014-10-09

• Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma, 2017-02-09

• Anticancer properties of bisaminoquinolines with modified linkers, 2021-07-21

• BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth, 2015-01-23

• FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA Preliminary Results From a Phase I/II Clinical Treatment Trial, 2018-06-15

• T-cell invigoration to tumour burden ratio associated with anti-PD-1 response, 2017-04-10

• Multidrug Analyses in Patients Distinguish Efficacious Cancer Agents Based on Both Tumor Cell Killing and Immunomodulation, 2017-03-31

• TOX transcriptionally and epigenetically programs CD8+T cell exhaustion, 2019-06-17

• A multicenter phase I study evaluating dual PI3K and BRAF inhibition with PX-866 and vemurafenib in patients with advanced BRAF V600 mutant solid tumors, 2017-10-19

• CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers, 2017-06-27

• Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma, 2018-03-21

• Targeting the unfolded protein response in cancer, 2017-04-08

• Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer, 2020-12-29

• Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts and PDX models, 2019-11-12

• Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells, 2021-05-11

• Autophagy inhibition to augment mTOR inhibition: A phase I/II trial of everolimus and hydroxychloroquine in patients with previously treated renal cell carcinoma, 2019-01-11

• Regulation of autophagy by canonical and non-canonical ER stress responses, 2019-12-12

• Multiple gastrointestinal polyps in patients treated with BRAF inhibitors, 2015-07-22

• Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma, 2011-02-15

• Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations, 2018-06-13

• ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma, 2018-12-18

• Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials, 2021-05-14

• Developmental Relationships of Four Exhausted CD8+T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms, 2020-05-11

• Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer, 2015-03-09

• Diverse cutaneous side effects associated with BRAF inhibitor therapy: A clinicopathologic study, 2012-05-18

• A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299, 2019-11-23

• PUMA: a puzzle piece in chloroquine's antimelanoma activity, 2013-04-03

• A Single Dose of Neoadjuvant PD-1 Blockade Predicts Clinical Outcomes in Resectable Melanoma, 2019-02-25

• Targeting Autophagy in Cancer: Recent Advances and Future Directions, 2019-08-21

• Autophagy in major human diseases, 2021-08-30

• Lysosomal lipid peroxidation regulates tumor immunity, 2023-04-17

• Paradoxical role for wild type p53 in driving therapy resistance in melanoma, 2019-12-11

• Survival Outcomes of Patients with Clinical Stage III Melanoma in the Era of Novel Systemic Therapies, 2019-07-03

• Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2, 2013-10-08

• Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers, 2022-03-08

• Targeting quiescent leukemic stem cells using second generation autophagy inhibitors, 2018-09-05

• Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers A Randomized Clinical Trial Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers, 2020-09-30

• Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma, 2023-05-09

• A unified approach to targeting the lysosome's degradative and growth signaling roles, 2017-09-12

• Targeting autophagy in cancer, 2018-04-19

• Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade, 2016-12-01

• Autophagy levels are elevated in Barrett's esophagus and promote cell survival from acid and oxidative stress, 2015-09-16

• Neural crest-like stem cell transcriptome analysis identifies LPAR1 in melanoma progression and therapy resistance., 2021-08-30

• Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy, 2022-10-10

• The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells, 2013-02-12

• miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment, 2015-05-16

• Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis and poor outcome, 2011-11-11

• PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors inBRAF-mutant Melanomas, 2017-09-27

• Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma, 2013-09-19