Dr. Mel Feany, MD

• Neuropathology

• Anatomic Pathology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Brigham And Women's Hospital

  Fellowship Hospital

• Albert Einstein College Of Medicine

  Medical School, 1995

• Lamin Dysfunction Mediates Neurodegeneration in Tauopathies, 2015-12-24

• The Parkinson's disease protein alpha-synuclein is a modulator of Processing-bodies and mRNA stability, 2022-06-09

• a-synuclein impairs autophagosome maturation through abnormal actin stabilization, 2021-02-08

• Alexander Disease, 2012-04-11

• STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease, 2023-03-23

• Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of TauIn Vivo, 2010-07-15

• The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo, 2010-09-29

• Connecting the Dots Between Tau Dysfunction and Neurodegeneration, 2014-08-26

• Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicityin vivo, 2009-02-09

• Case Study 1: A 55-Year-Old Woman With Progressive Cognitive, Perceptual, and Motor Impairments, 2021-11-12

• Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease, 2018-05-15

• Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping, 2022-10-03

• Alpha-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease, 2009-07-24

• Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease, 2023-09-18

• Tau promotes neurodegeneration via DRP1 mislocalization in vivo, 2012-08-23

• a-synuclein promotes neuronal dysfunction and death by disrupting the binding of ankyrin to ß-spectrin, 2023-06-05

• Parkinson's disease risk genes act in glia to control neuronal a-synuclein toxicity, 2021-08-11

• Glial a-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo, 2019-07-03

• Oligomerization of Lrrk controls actin severing and a-synuclein neurotoxicity in vivo, 2021-05-24

• Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease, 2023-04-03

• Tau promotes neurodegeneration through global chromatin relaxation, 2014-01-26

• Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics, 2018-12-20

• Nitric oxide mediates glial-induced neurodegeneration in Alexander disease, 2015-11-26

• Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment**, 2021-11-17

• A genetic basis for the variable effect of smoking/nicotine on Parkinson's disease, 2012-10-02

• a-synuclein induces mitochondrial dysfunction through spectrin and the actin cytoskeleton, 2017-12-14

• Comparative proteomic analysis highlights metabolic dysfunction in a-synucleinopathy, 2020-12-11

• Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form, 2017-07-12