Dr. Matthew Frosch, MD

• Neuropathology

• Anatomic Pathology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Brigham & Women's Hosp/children's Hospital

  Fellowship Hospital, 1992

• Brigham And Womens Hospital

  Residency Hospital, 1989

• Harvard Medical School

  Medical School, 1987

• Rare coding variants inPLCG2, ABI3andTREM2implicate microglial-mediated innate immunity in Alzheimer's disease, 2017-07-17

• Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain, 2015-10-13

• Different microvascular alterations underlie microbleeds and microinfarcts, 2019-06-14

• Novel Progranulin Mutation Detected in 2 Patients With FTLD, 2013-06-18

• Spinocerebellar Ataxia Type 7: Clinical Course, Phenotype-Genotype Correlations, and Neuropathology, 2012-10-17

• Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment, 2023-03-02

• Premature vascular disease in young adult stroke: a pathology-based case series., 2019-12-18

• 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal, 2018-05-09

• Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping, 2022-10-03

• Optical coherence tomography visualizes neurons in human entorhinal cortex, 2015-02-09

• Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS, 2010-10-17

• National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease, 2011-11-14

• Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease, 2020-06-22

• [F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging, 2017-06-13

• Different tau species lead to heterogeneous tau pathology propagation and misfolding, 2018-11-29

• Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models, 2013-07-02

• Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study, 2020-02-03

• Inhibitory CD161 Receptor Identified in Glioma-infiltrating T cells by Single Cell Analysis, 2021-02-15

• Quantitative and histologically validated measures of the entorhinal subfields inex vivoMRI, 2022-03-25

• Common variants inMS4A4/MS4A6E, CD2uAP, CD33, andEPHA1are associated with late-onset Alzheimer's disease, 2011-04-03

• Learnings about Aß from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics, 2023-03-10

• Common genetic variants in theCLDN2andPRSS1-PRSS2loci alter risk for alcohol-related and sporadic pancreatitis, 2012-11-11

• Cerebellar microbleed distribution patterns and cerebral amyloid angiopathy: a MRI and pathology-based study, 2019-06-04

• Reducing Available Soluble ß-Amyloid Prevents Progression of Cerebral Amyloid Angiopathy in Transgenic Mice, 2012-10-24

• Simple, scalable proteomic imaging for high-dimensional profiling of intact systems, 2015-12-03

• The aqueous phase of Alzheimer's disease brain contains assemblies built from ~4 and ~7 kDa Aß species, 2015-04-04

• Histopathology of diffusion-weighted imaging-positive lesions in cerebral amyloid angiopathy, 2020-02-27

• Microemboli May Link Spreading Depression, Migraine Aura, and Patent Foramen Ovale, 2010-07-26

• Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease, 2018-09-17

• Genome-Encoded Cytoplasmic Double-Stranded RNAs, Found inC9ORF72ALS-FTD Brain, Propagate Neuronal Loss, 2021-07-07

• Amyloid Related Imaging Abnormalities (ARIA) in Amyloid Modifying Therapeutic Trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup, 2013-06-03

• Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy, 2022-08-23

• TMEM106Bis a genetic modifier of frontotemporal lobar degeneration withC9orf72hexanucleotide repeat expansions, 2014-01-19

• Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of "Rebound” Revascularization as Mode of Escape, 2011-01-01

• Spatial Relation between Microbleeds and Amyloid Deposits in Amyloid Angiopathy, 2010-06-15

• Stable Size Distribution of Amyloid Plaques Over the Course of Alzheimer Disease, 2012-06-18

• Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease, 2014-10-21

• Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients, 2016-08-03

• Somatic genomic changes in single Alzheimer's disease neurons, 2022-04-20

• Entorhinal Subfield Vulnerability to Neurofibrillary Tangles in Aging and the Preclinical Stage of Alzheimer's Disease Entorhinal Subfield Vulnerability to Neurofibrillary Tangles, 2022-04-25

• Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages, 2022-05-09

• Estimating total cerebral microinfarct burden from diffusion-weighted imaging, 2015-07-09

• PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins, 2019-12-18

• Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case, 2017-10-19

• Studying synapses in human brain with array tomography and electron microscopy, 2013-06-20

• Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy, 2016-10-22

• Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis, 2021-08-31

• Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice, 2014-11-27

• Secondary bleeding during acute experimental intracerebral hemorrhage, 2019-03-16

• Synaptic plasticity defect following visual deprivation in Alzheimer disease model transgenic mice, 2012-06-06

• Histopathology of Cerebral Microinfarcts and Microbleeds in Spontaneous Intracerebral Hemorrhage, 2022-04-06

• Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer's cases, 2021-05-04

• The common inhalation anesthetic isoflurane induces caspase activation and increases Aß levelin vivo, 2008-10-24

• Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue, 2019-03-11

• Elasticizing tissues for reversible shape transformation and accelerated molecular labeling, 2020-05-18

• Validating novel tau PET tracer [F-18]-AV-1451 (T807) on postmortem brain tissue, 2015-09-25

• Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions, 2010-02-14

• Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq, 2017-03-31

• Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias, 2014-09-04

• Enhanced dendritic compartmentalization in human cortical neurons, 2018-10-18

• Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening, 2015-11-13

• An integrative model of cellular states, plasticity and genetics for glioblastoma, 2019-07-18

• Mild to Moderate Alzheimer Dementia with Insufficient Neuropathological Changes, 2014-04-08

• Differential recognition of vascular and parenchymal beta amyloid deposition, 2009-12-16

• A vicious cycle of amyloid ß-dependent neuronal hyperactivation, 2019-08-09

• Matrix Metalloproteinase 9 mediated intracerebral hemorrhage induced by Cerebral amyloid angiopathy, 2015-07-16

• Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease, 2022-02-02

• Entorhinal verrucae geometry is coincident and correlates with Alzheimer's lesions: a combined neuropathology and high resolutionex vivoMRI analysis, 2011-12-13

• The Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice, 2010-07-20

• Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease, 2013-05-09

• Stereology neuron counts correlate with deep learning estimates in the human hippocampal subregions, 2023-04-11

• Does DIA data contain hidden gems? A case study related to Alzheimer's disease, 2021-11-24

• Knowledge gaps and research recommendations for essential tremor, 2016-10-04

• Impairment of visual cortical plasticity by amyloid-beta species, 2021-03-22

• Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage, 2015-06-13

• Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue, 2016-09-15

• An in vitro paradigm to assess potential anti-Aß antibodies for Alzheimer's disease, 2018-07-11

• Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma, 2020-03-23

• A computational atlas of the hippocampal formation usingex vivo, ultra-high resolution MRI: Application to adaptive segmentation ofin vivoMRI, 2015-04-29

• Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and ?-secretase independent redistribution, 2013-10-23

• Simultaneous protection of tissue physicochemical properties using polyfunctional crosslinkers, 2018-12-17

• as-PSOCT: volumetric microscopic imaging of human brain architecture and connectivity, 2017-10-07

• Endosulfine-alpha inhibits membrane-induced a-synuclein aggregation and protects against a-synuclein neurotoxicity, 2017-01-10

• Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq, 2018-04-20

• Perivascular Space Dilation is Associated with Vascular Amyloid-ß Accumulation in the Overlying Cortex, 2021-12-20

• Diffusible, highly bioactive oligomers represent a critical minority of soluble Aß in Alzheimer's disease brain, 2018-04-23

• Modeling Intracerebral Hemorrhage Growth and Response to Anticoagulation, 2012-10-30

• Pathologic correlations of [F-18]-AV-1451 imaging in non-Alzheimer tauopathies, 2017-02-01

• Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons, 2021-05-12

• Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathyin vivoin transgenic mice, 2009-04-08

• Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain, 2018-04-24

• Novel compound heterozygous mutations expand the recognized phenotypes ofFARS2-linked disease, 2016-04-19

• Allometric rules for mammalian cortical layer 5 neuron biophysics, 2021-11-10

• PrP-grafted antibodies bind certain amyloid ß-protein aggregates, but do not prevent toxicity, 2018-12-26

• Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy In Elderly Subjects Without Alzheimer Disease, 2009-08-14

• H.M.'s Contributions to Neuroscience: A Review and Autopsy Studies, 2014-09-23

• Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage, 2019-01-08

• Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid ß peptide, 2012-10-24

• Blood-brain barrier leakage and microvascular lesions in cerebral amyloid angiopathy, 2018-12-21

• [18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series, 2019-10-28

• Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma, 2016-11-02

• Vasomotion as a driving force for paravascular clearance in the awake mouse brain, 2019-12-03

• Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease, 2020-09-16

• Blockface Histology with Optical Coherence Tomography: A Comparison with Nissl Staining, 2013-09-13

• A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease, 2023-04-14

• Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing, 2019-02-28

• A NovelGRNMutation (GRNc.708+6_+9delTGAG) in Frontotemporal Lobar Degeneration with TDP-43-positive Inclusions: Clinicopathologic Report of 6 Cases, 2014-06-21

• a-Synuclein: Prion or Prion-like?, 2019-08-12

• Distinct cytokine profiles in human brains resilient to Alzheimer's pathology, 2018-10-15

• Pentad: A reproducible cytoarchitectonic protocol and its application to parcellation of the human hippocampus, 2023-02-09

• Genome-wide association study and functional validation implicates JADE1 in tauopathy, 2021-11-01

• Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease, 2022-02-23

• Histopathological correlates of haemorrhagic lesions onex vivomagnetic resonance imaging in immunized Alzheimer's disease cases, 2022-02-03

• National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach, 2011-11-20