Dr. Mark Frye, MD

• Psychiatry

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• University Of Minnesota / Saint Paul Campus

  Medical School, 2007

• Dissecting clinical heterogeneity of bipolar disorder using multiple polygenic risk scores, 2020-09-18

• Lipid peroxidation biomarkers in adolescents with or at high-risk for bipolar disorder, 2015-12-23

• Shared Genetic Risk between Eating Disorder and Substance Use-Related Phenotypes: Evidence from Genome-Wide Association Studies, 2020-02-16

• Differential Dorsolateral Prefrontal Cortex Proteomic Profiles of Suicide Victims with Mood Disorders, 2020-02-27

• Pilot Study of Metabolomic Clusters as State Markers of Major Depression and Outcomes to CBT Treatment, 2019-09-12

• Transcranial Magnetic Stimulation Potentiates Glutamatergic Neurotransmission in Depressed Adolescents, 2015-11-27

• Genetic variant inSLC1A2is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling, 2019-05-23

• Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation, 2020-04-23

• Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics, 2018-01-10

• Mood Stability in Parkinson's Disease Status Post Deep Brain Stimulation: A 6-Month Prospective Follow-up Study, 2013-12-21

• Clinical and Genetic Correlates of Bipolar Disorder With Childhood-Onset Attention Deficit Disorder, 2022-04-14

• Mood Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome-Wide Association Study, 2020-08-07

• Baseline thyroid indices and the subsequent response to citalopram treatment, a pilot study, 2013-01-18

• Depressive symptoms carry an increased risk for suicidal ideation and behavior in bipolar disorder without any additional contribution of mixed symptoms, 2018-12-21

• Acylcarnitine Metabolomic Profiles Inform Clinically-Defined Major Depressive Phenotypes, 2019-11-30

• Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder, 2019-12-09

• Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients, 2019-07-04

• Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder, 2019-06-26

• Association of Bipolar Disorder with Major Adverse Cardiovascular Events: A Population-Based Historical Cohort Study, 2022-01-01

• Bipolar disorder with comorbid binge eating history: A genome-wide association study implicatesAPOB, 2014-04-19

• Long-Term Lithium Therapy and Thyroid Disorders in Bipolar Disorder: A Historical Cohort Study, 2023-01-12

• Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication, 2021-10-07

• Nucleus Accumbens Deep Brain Stimulation Results in Insula and Prefrontal Activation: A Large Animal fMRI Study, 2013-02-18

• ERICH3: Vesicular Association and Antidepressant Treatment Response, 2020-11-23

• Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression, 2021-03-02

• Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis, 2022-06-27

• TCF7L2lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling, 2021-09-17

• Mapping Depression Rating Scale Phenotypes onto Research Domain Criteria (RDoC) to Inform Biological Research in Mood Disorders, 2018-05-26

• Bipolar disorder with binge eating behavior: a genome-wide association study implicatesPRR5-ARHGAP8, 2018-02-02

• Association of thePDYNgene with alcohol dependence and the propensity to drink in negative emotional states, 2012-10-29

• N-acetylaspartate normalization in bipolar depression after lamotrigine treatment, 2014-12-12

• Replication of Genome Wide Association Studies of Alcohol Dependence: Support for Association with Variation inADH1C, 2013-03-13

• Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders, 2018-11-26

• Mixed mania associated with cessation of breastfeeding, 2016-09-05

• Association ofGATA4sequence variation with alcohol dependence, 2012-08-02

• Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder, 2018-09-10

• Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients, 2021-11-29

• Mania and bipolar depression: complementing not opposing poles-a post-hoc analysis of mixed features in manic and hypomanic episodes, 2021-11-16

• Differences in demographic composition and in work, social, and functional limitations among the populations with unipolar depression and bipolar disorder: results from a nationally representative sample, 2011-10-13

• Plasma Cell-Free DNA Methylomics of Bipolar Disorder With and Without Rapid Cycling, 2021-11-30

• Benefits of and Barriers to Pharmacogenomics-Guided Treatment for Major Depressive Disorder, 2018-02-01

• The genetics of bipolar disorder with obesity and type 2 diabetes, 2022-06-30

• Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder, 2015-08-06

• Gender Differences in the Relationship between Depressive Symptoms and Cravings in Alcoholism, 2015-11-14

• Characterisation of age and polarity at onset in bipolar disorder, 2021-12-01

• A Randomized, Controlled Trial of Combinatorial Pharmacogenetics Testing in Adolescent Depression, 2021-06-05

• A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions, 2019-02-13

• Centromedian-Parafascicular Deep Brain Stimulation Induces Differential Functional Inhibition of the Motor, Associative, and Limbic Circuits in Large Animals, 2013-08-30

• Randomized, placebo-controlled, adjunctive study of armodafinil for bipolar I depression: implications of novel drug design and heterogeneity of concurrent bipolar maintenance treatments, 2015-09-02

• Augmentation strategies for treatment resistant major depression: A systematic review and network meta-analysis, 2022-01-02

• 2040 Symptom endorsement in bipolar patients of African Versus European ancestry, 2018-11-21

• 25 Years of the International Bipolar Collaborative Network (BCN), 2021-04-02

• Prediction of short-term antidepressant response using probabilistic graphical models with replication across multiple drugs and treatment settings, 2021-01-15

• Label-free proteomics differences in the dorsolateral prefrontal cortex between bipolar disorder patients with and without psychosis, 2020-04-08

• Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states, 2016-05-05

• Stimulation-Induced Transient Non-Motor Psychiatric Symptoms Following Subthalamic Deep Brain Stimulation in Patients with Parkinson's Disease: Association with Clinical Outcomes and Neuroanatomical Correlates, 2016-04-20

• TSPAN5,ERICH3and Selective Serotonin Reuptake Inhibitors in Major Depressive Disorder: Pharmacometabolomics-informed Pharmacogenomics, 2016-02-23

• Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine Learning Approach with Multi-Trial Replication, 2019-06-29

• Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania, 2022-12-13

• Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients, 2022-07-11

• Potential pharmacogenomic targets in bipolar disorder: considerations for current testing and the development of decision support tools to individualize treatment selection, 2020-07-04

• Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report, 2013-06-19

• Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance, 2019-03-15

• Pharmacokinetic-Pharmacodynamic interaction associated with venlafaxine-XR remission in patients with major depressive disorder with history of citalopram / escitalopram treatment failure, 2018-12-17

• Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study, 2016-01-22

• Excessive Sleepiness and Associated Symptoms in the US adult Population: Prevalence, Correlates and Comorbidity, 2019-11-02

• Self-report screening instruments differentiate bipolar disorder and borderline personality disorder, 2021-05-30

• National Survey and Community Advisory Board Development for a Bipolar Disorder Biobank, 2015-08-20

• Inferring multimodal latent topics from electronic health records, 2020-05-21

• Racial differences in pathways to care preceding first episode mania or psychosis: a historical cohort prodromal study, 2023-09-04

• HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders, 2021-09-08

• Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses, 2015-06-24

• Underlying Neurobiology and Clinical Correlates of Mania Status-Post Subthalamic Nucleus Deep Brain Stimulation in Parkinson's disease: A Review of the Literature, 2013-01-29