Dr. Luis Diaz Jr, MD

• Hematology & Oncology

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• University Of Michigan / Medical Center

  Medical School, 1998

• A Single Institution's 26-Year Experience With Nonfunctional Pancreatic Neuroendocrine Tumors A Validation of Current Staging Systems and a New Prognostic Nomogram, 2014-03-07

• DAXX/ATRX, MEN1 and mTOR Pathway Genes are Frequently Altered in Pancreatic Neuroendocrine Tumors, 2011-01-20

• Tumor genomic alterations in severe-combined immunodeficiency bare-lymphocyte syndrome genes are associated with high mutational burden and disproportional neo-antigen rates, 2019-05-07

• Acquired resistance to immunotherapy in MMR-D pancreatic cancer, 2018-11-20

• Non-invasive detection of microsatellite instability and high tumor mutation burden in cancer patients treated with PD-1 blockade, 2019-09-10

• Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade, 2014-12-16

• DNA sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity, 2020-12-17

• Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition, 2018-10-24

• Treating Patients with Colon Cancer Liver Metastasis: A Nationwide Analysis of Therapeutic Decision Making, 2012-08-09

• Circulating Tumor DNA as a Marker of Therapeutic Response in Patients With Renal Cell Carcinoma: A Pilot Study, 2016-03-24

• Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes, 2014-09-19

• Genome-wide mutational signatures in low-coverage whole genome sequencing of cell-free DNA, 2022-08-23

• Detection and localization of surgically resectable cancers with a multi-analyte blood test, 2018-01-18

• PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon, 2022-06-02

• Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer, 2016-07-06

• Circulating tumor DNA moves further into the spotlight, 2014-05-28

• A machine learning approach for somatic mutation discovery, 2018-09-05

• Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade, 2017-06-08

• Heteroplasmic mitochondrial DNA mutations in normal and tumor cells, 2010-03-03

• Direct detection of early-stage cancers using circulating tumor DNA, 2017-08-16

• An Integrated Genomic Analysis of Human Glioblastoma Multiforme, 2008-09-04

• FrequentATRX,CIC,FUBP1andIDH1mutations refine the classification of malignant gliomas, 2012-08-03

• Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer, 2017-06-21

• Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations, 2018-01-24

• Immunotherapy in colorectal cancer: rationale, challenges and potential, 2020-05-21

• Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas, 2015-06-24

• INTRATUMORAL ADAPTIVE IMMUNOSUPPRESSION AND TYPE 17 IMMUNITY IN MISMATCH REPAIR PROFICIENT COLORECTAL TUMORS, 2019-05-06

• Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response, 2019-05-03

• Detection of tumor DNA at the margins of colorectal cancer liver metastasis, 2011-04-29

• Cancer therapy shapes the fitness landscape of clonal hematopoiesis, 2020-10-26

• Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers Clonal Hematopoiesis in Gastrointestinal Tract Cancer Treatment, 2023-02-02

• Clinical and molecular predictors of response to immune checkpoint inhibitors in patients with advanced esophagogastric cancer, 2019-07-23

• A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles, 2011-03-22

• Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1, 2019-02-11

• Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers, 2018-03-21

• Baseline Hemoglobin-A1c Impacts Clinical Outcomes in Patients with Pancreatic Cancer, 2014-06-14

• A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles, 2011-03-01

• Are Financial Payments from the Pharmaceutical Industry Associated with Physician Prescribing? A Systematic Review, 2020-11-24

• Longer course of induction chemotherapy followed by chemoradiation favors better survival outcomes for patients with locally advanced pancreatic cancer, 2014-01-06

• Cellular localization of PD-L1 expression in mismatch repair-deficient and proficient colorectal carcinomas., 2018-08-30

• Gemcitabine, Docetaxel, Capecitabine, Cisplatin, Irinotecan as First-line Treatment for Metastatic Pancreatic Cancer, 2023-08-28

• Exomic Analysis of Myxoid Liposarcomas, Synovial Sarcomas, and Osteosarcomas, 2013-11-05

• Evaluation of Ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer, 2013-08-23

• Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study, 2022-04-12

• Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers, 2023-03-17

• A randomized pilot trial of a telephone-based couples intervention for physical intimacy and sexual concerns in colorectal cancer, 2014-02-26

• Machine learning-based prediction of microsatellite instability and high tumor mutation burden from contrast-enhanced computed tomography in endometrial cancers, 2020-10-20

• The Spectrum of Benefit from Checkpoint Blockade in Hypermutated Tumors, 2021-03-25

• The Impact of Insurance on Access to Cancer Clinical Trials at a Comprehensive Cancer Center, 2010-12-15

• A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts, 2015-08-04

• Phase I Trial of Intravenous Mistletoe Extract in Advanced Cancer, 2023-02-28

• The Early Detection of Pancreatic Cancer: What Will it Take to Diagnose and Treat Curable Pancreatic Neoplasia?, 2014-06-12

• Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1, 2019-03-06

• Mismatch Repair Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy, 2020-03-06

• Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs, 2021-03-23

• Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies, 2014-02-19

• Cutaneous eruptions in patients receiving immune checkpoint blockade: Clinicopathologic analysis of the non-lichenoid histologic pattern, 2017-06-05

• Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy” blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study, 2022-04-26

• Amplification of theMETreceptor drives resistance to anti-EGFR therapies in colorectal cancer, 2013-06-02

• Pre- and post-operative plasma glial fibrillary acidic protein levels in patients with newly diagnosed gliomas, 2012-04-11

• Imaging of Musculoskeletal Bacterial Infections by [124I]FIAU-PET/CT, 2007-10-10

• Clinicopathologic Comparison of High-Dose-Rate Endorectal Brachytherapy versus Conventional Chemoradiotherapy in the Neoadjuvant Setting for Resectable Stages II and III Low Rectal Cancer, 2012-07-08

• TERTPromoter Mutations Occur Early in Urothelial Neoplasia and are Biomarkers of Early Disease and Disease Recurrence in Urine, 2013-10-11

• The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers, 2012-06-28

• Family history as a marker of platinum sensitivity in pancreatic adenocarcinoma, 2015-07-01

• Pharmacologic modulation of RNA splicing enhances anti-tumor immunity, 2021-06-24

• Intratumoral injection ofClostridium novyi-NT spores induces antitumor responses, 2014-08-13

• The Genomic Landscape of Response to EGFR Blockade in Colorectal Cancer, 2015-09-30

• Evaluation of predictive variables in locally advanced pancreatic adenocarcinoma patients receiving definitive chemoradiation, 2011-08-03

• Automated next-generation profiling of genomic alterations in human cancers, 2022-05-20

• IMMUNOPATHOLOGIC STRATIFICATION OF COLORECTAL CANCER FOR CHECKPOINT BLOCKADE IMMUNOTHERAPY, 2019-08-22

• Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients, 2015-07-07

• Glucose Deprivation Contributes to the Development ofKRASPathway Mutations in Tumor Cells, 2009-08-06

• Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis, 2021-01-12

• Incidence and Prognostic Impact of KRAS and BRAF Mutation in Patients Undergoing Liver Surgery for Colorectal Metastases, 2013-09-19

• Sensitive digital quantification of DNA methylation in clinical samples, 2009-08-16

• Clonal hematopoiesis is associated with risk of severe Covid-19, 2021-10-13

• Personalized genomic analyses for cancer mutation discovery and interpretation, 2015-04-15

• TNF-blockade in Patients with Advanced Hormone Refractory Prostate Cancer, 2009-10-21

• Liquid Biopsies: Genotyping Circulating Tumor DNA, 2014-01-21

• Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls, 2023-03-29

• Detection of SomaticTP53Mutations in Tampons of Patients With High-Grade Serous Ovarian Cancer, 2015-01-31

• 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one National Harbor, MD, USA. 9-13 November 2016, 2016-11-16

• Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers, 2013-01-09

• Primary resistance to PD-1 blockade mediated byJAK1/2mutations, 2016-11-30

• Majority ofB2M-Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High, 2019-03-04