Dr. Kenneth Margulies, MD

• Cardiology

• Advanced Heart Failure & Transplant Cardiology

• Internal Medicine

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• Thomas Jefferson University

  Medical School, 1987

• GLP-1 Agonist Therapy for Advanced Heart Failure with Reduced Ejection Fraction: Design and Rationale for the Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT) Study, 2014-06-11

• Circadian Pattern of Ion Channel Gene Expression in Failing Human Hearts, 2020-12-10

• Whole-Transcriptome Profiling of Human Heart Tissues Reveals the Potential Novel Players and Regulatory Networks in Different Cardiomyopathy Subtypes of Heart Failure, 2021-02-01

• Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure with Reduced Ejection Fraction: DEFINE-HF, 2022-05-23

• Response to Letter Regarding Article, "Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction”, 2015-08-25

• Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure, 2020-04-02

• Common Coding Variants inSCN10Aare associated with the Nav1.8 Late Current and Cardiac Conduction, 2019-01-29

• Cardiac retinoic acid levels decline in heart failure, 2021-04-22

• Myocardial Gene Expression Signatures in Human Heart Failure with Preserved Ejection Fraction, 2020-10-29

• Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure, 2022-11-14

• BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure, 2013-08-01

• Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte, 2011-11-22

• In vivolabel-free structural and biochemical imaging of coronary arteries using an integrated ultrasound and multispectral fluorescence lifetime catheter system, 2017-08-21

• Noncanonical WNT Activation in Human Right Ventricular Heart Failure, 2020-10-07

• Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes - a study in humans and rats Despa; Cardiotoxicity of Hyperamylinemia, 2012-01-24

• Transcription Factor 7-like 2 Mediates Canonical Wnt/ß-Catenin Signaling and c-Myc Upregulation in Heart Failure, 2016-06-14

• Effects of Liraglutide on Worsening Renal Function among Patients with Heart Failure with Reduced Ejection Fraction: Insights from the FIGHT Trial, 2020-05-04

• Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure With Preserved Ejection Fraction, 2015-03-17

• Multiple Plasma Biomarkers for Risk Stratification in Patients with Heart Failure and Preserved Ejection Fraction, 2020-03-24

• Med25 Limits Master Regulators That Govern Adipogenesis, 2023-03-24

• Extracellular stiffness induces contractile dysfunction in adult cardiomyocytes via cell-autonomous and microtubule-dependent mechanisms, 2022-08-25

• Differential Expression of PDE5 in Failing and Non-Failing Human Myocardium, 2011-12-01

• Functional consequences of memory inflation after solid-organ transplantation, 2021-09-22

• Genetic Reduction in Left Ventricular Protein Kinase C alpha and Adverse Ventricular Remodeling in Human Subjects, 2018-01-24

• Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation, 2018-06-11

• Targeting Cardiac Fibrosis with Engineered T cells, 2019-09-11

• Advanced Morphologic Analysis for Diagnosing Allograft Rejection: The Case of Cardiac Transplant Rejection, 2018-03-18

• Mitochondrial protein hyperacetylation in the failing heart, 2016-02-25

• Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease M Dukinfieldet al, 2019-10-30

• Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability, 2015-10-12

• PathogenicLMNAvariants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes, 2021-02-01

• Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial, 2017-09-01

• CMV-Responsive CD4 T Cells Have a Stable Cytotoxic Phenotype Over the First Year Post-Transplant in Patients Without Evidence of CMV Viremia, 2022-06-28

• Phosphodiesterase 9A Controls Nitric-oxide Independent cGMP and Hypertrophic Heart Disease, 2015-03-18

• Effects of Organic and Inorganic Nitrate on Aortic and Carotid Hemodynamics in Heart Failure and Preserved Ejection Fraction, 2017-05-25

• Genetic and phenotypic landscape of peripartum cardiomyopathy, 2021-04-20

• C-type natriuretic peptide co-ordinates cardiac structure and function, 2019-03-21

• Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation, 2019-10-04

• Nuclear Deformation Guides Chromatin Reorganization in Cardiac Development and Disease, 2021-12-02

• Mechanically dynamic PDMS substrates to investigate changing cell environments, 2017-08-17

• Cardioprotective effects ofMTSS1enhancer variants, 2019-04-23

• Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation, 2020-11-06

• Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure, 2019-06-24

• Microtubules increase diastolic stiffness in failing human cardiomyocytes and myocardium, 2020-01-16

• SEX AND AGE DIMORPHISM OF MYOCARDIAL GENE EXPRESSION IN NONISCHEMIC HUMAN HEART FAILURE, 2008-12-09

• Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants, 2021-11-17

• Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure, 2016-05-05

• Cytomegalovirus responsive CD8+T cells expand after solid organ transplantation in the absence of CMV disease, 2017-03-13

• Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure, 2020-01-09

• Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The EXACT-HF Study, 2015-04-14

• Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure, 2023-02-14

• Detailed Echocardiographic Phenotyping in Breast Cancer Patients: Associations with Ejection Fraction Decline, Recovery, and Heart Failure Symptoms over 3 Years of Followup, 2017-01-19

• Sparse simultaneous signal detection for identifying genetically controlled disease genes, 2017-01-05

• Pulmonary Artery Pulsatility Index Predicts Right Ventricular Myofilament Dysfunction in Advanced Human Heart Failure, 2021-01-05

• Fluorescence Lifetime Imaging Combined with Conventional Intravascular Ultrasound for Enhanced Assessment of Atherosclerotic Plaques: an Ex Vivo Study in Human Coronary Arteries, 2015-05-01

• The Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure with Preserved Ejection Fraction, 2014-12-22

• CaMKII Phosphorylation of NaV1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure, 2015-04-13

• Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant, 2021-05-27

• Transcriptional and Cellular Diversity of the Human Heart, 2020-05-14

• Sirtuin1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel, 2017-02-13

• Investigating Origins of FLIm Contrast in Atherosclerotic Lesions Using Combined FLIm-Raman Spectroscopy, 2020-07-21

• Safety and Effectiveness of Intravenous Iron Therapy in Patients Supported by Durable Left Ventricular Assist Devices, 2022-07-04

• Evolution of cytomegalovirus-responsive T cell clonality following solid-organ transplantation, 2021-09-22

• Homeodomain Only Protein Xis down-regulated in human heart failure, 2011-03-05

• Divergent Mitochondrial Biogenesis Responses in Human Cardiomyopathy, 2013-04-15

• The Anemia Stress Index-Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices, 2022-08-03

• Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuningin vitroAfterload, 2023-03-06

• Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure, 2020-06-01

• Computational Analysis of Routine Biopsies Improves Diagnosis and Prediction of Cardiac Allograft Vasculopathy, 2022-04-11

• Intensification of Medication Therapy for Cardiorenal Syndrome in Acute Decompensated Heart Failure, 2015-07-21

• Effect of Heart Failure with Preserved Ejection Fraction on Nitric Oxide Metabolites, 2016-09-15

• Genomics-first evaluation of heart disease associated with Titin-truncating variants, 2019-06-20

• A low voltage activated Ca2+current found in a subset of human ventricular myocytes CHANNELS, 2020-07-20

• Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy, 2021-01-12

• Low Dose Dopamine or Low Dose Nesiritide in Acute Heart Failure with Renal Dysfunction: The ROSE Acute Heart Failure Randomized Trial, 2013-12-18

• Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy, 2022-08-29

• Comparing Raman and Fluorescence lifetime spectroscopy from human atherosclerotic lesions using a bimodal probe, 2016-03-22

• A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue, 2018-04-03

• Label-free visualization and quantification of biochemical markers of atherosclerotic plaque progression using intravascular fluorescence lifetime, 2020-11-18

• Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction, 2016-12-07

• A Bioengineered Hydrogel System Enables Targeted and Sustained Intramyocardial Delivery of Neuregulin, Activating the Cardiomyocyte Cell Cycle and Enhancing Ventricular Function in a Murine Model of Ischemic Cardiomyopathy, 2014-06-05

• Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy, 2022-05-11