Dr. Karen Costenbader, MD

• Rheumatology

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• Harvard Medical School

  Medical School, 1995

• The roles of post-diagnosis accumulation of morbidities and lifestyle changes on excess total and cause-specific mortality risk in rheumatoid arthritis., 2019-12-09

• Comparison of an Administrative Algorithm for SLE Disease Severity to Clinical SLE Disease Activity Index Scores, 2019-11-29

• Dynamic Patterns and Predictors of Hydroxychloroquine Nonadherence among Medicaid Beneficiaries with Systemic Lupus Erythematosus, 2018-01-08

• Administrative Algorithms to identify Avascular necrosis of bone among patients undergoing upper or lower extremity magnetic resonance imaging: a validation study, 2017-06-19

• Biomarkers of Inflammation and Development of Rheumatoid Arthritis in Women From Two Prospective Cohort Studies, 2009-01-27

• Trends in the Incidence, Demographics and Outcomes of End-Stage Renal Disease Due to Lupus Nephritis in the U.S., 1995-2006, 2011-02-07

• Soluble Mediators and Clinical Features Discern Risk of Transitioning to Classified Disease in Relatives of Systemic Lupus Erythematosus Patients, 2016-09-30

• Understanding the Concept of Pre-Clinical Autoimmunity: Prediction and Prevention of Systemic Lupus Erythematosus: Identifying Risk Factors and Developing Strategies Against Disease Development, 2022-06-03

• A Prospective Study of Obesity and Risk of Systemic Lupus Erythematosus (SLE) among Black Women, 2018-10-11

• Obesity and the Risk of Systemic Lupus Erythematosus among Women in the Nurses' Health Studies, 2017-05-25

• The 2010 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Rheumatoid Arthritis Phase 2 Methodological Report, 2011-01-24

• Race/Ethnicity and Cardiovascular Events among Patients with Systemic Lupus Erythematosus, 2017-08-13

• A Prospective Study of Periodontal Disease and Risk of Rheumatoid Arthritis, 2010-07-01

• Menopausal factors are associated with seronegative RA in large prospective cohorts: results from the Nurses' Health Studies, 2017-09-21

• Lipid Testing and Statin Prescription among Medicaid Recipients with Systemic Lupus Erythematosus, Diabetes Mellitus and the General Medicaid Population, 2018-04-07

• Association of Childhood Abuse with Incident Systemic Lupus Erythematosus in Adulthood in a Longitudinal Cohort of Women, 2019-05-15

• Clinical Characteristics and Renal Prognosis Associated with Interstitial Fibrosis and Tubular Atrophy (IFTA) and Vascular Injury in Lupus Nephritis Biopsies, 2019-06-11

• Perinatal Factors and Adult-Onset Lupus, 2008-08-15

• Association of Environmental and Genetic Factors and Gene-Environment Interactions with Risk of Developing Rheumatoid Arthritis, 2013-04-30

• Association of Child Abuse with Systemic Lupus Erythematosus in Black Women During Adulthood, 2020-04-10

• Clinical Manifestations and Survival among Adults with Systemic Lupus Erythematosus according to Age at Diagnosis, 2014-03-07

• Fish oil supplementation in patients with and without systemic lupus erythematosus: Targeting pro-inflammatory and pro-resolving lipid mediators, 2022-07-21

• Dietary Patterns and Risk of Systemic Lupus Erythematosus in Women, 2019-11-13

• Elevated BMI and Antibodies to Citrullinated Proteins Interact to Increase Rheumatoid Arthritis Risk and Shorten Time to Diagnosis: a Nested Case-Control Study of Women in the Nurses' Health Studies, 2016-09-13

• Long-term physical activity and subsequent risk for rheumatoid arthritis among women: A prospective cohort study, 2019-07-19

• Rheumatoid arthritis in 2017: Protective dietary and hormonal factors, 2018-01-11

• Contributions of Familial Rheumatoid Arthritis or Lupus and Environmental Factors to Risk of Rheumatoid Arthritis in Women: a Prospective Cohort Study, 2014-05-31

• Epstein-Barr Virus Serologic Abnormalities and risk of Rheumatoid Arthritis among Women, 2011-10-20

• Identifying Lupus Patients in Electronic Health Records: Development and Validation of Machine Learning Algorithms and Application of Rule-Based Algorithms, 2019-01-04

• Epidemiology of Environmental Exposures and Human Autoimmune Diseases: Findings from a National Institute of Environmental Health Sciences Expert Panel Workshop, 2012-06-25

• Mediterranean diet and incidence of rheumatoid arthritis in women, 2014-10-11

• Specific systemic lupus erythematosus disease manifestations in the six months prior to conception are associated with similar disease manifestations during pregnancy, 2015-05-12

• Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus, 2021-05-21

• Dietary intake of vitamin D during adolescence and risk of adult onset systemic lupus erythematosus and rheumatoid arthritis, 2012-07-13

• Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case-control study, 2013-10-23

• Systemic lupus erythematosus and risk of cardiovascular disease Results from the Nurses' Health Study, 2009-10-15

• We Need Better Classification and Terminology for "People at High-risk of or in the Process of Developing Lupus”, 2014-12-12

• Erythropoiesis-stimulating Agent Use among Patients with Lupus Nephritis Approaching End-stage Renal Disease, 2013-12-26

• All-Cause and Cause-Specific Mortality Trends of End-Stage Renal Disease due to Lupus Nephritis from 1995 to 2014, 2019-01-09

• Disclosure of personalized rheumatoid arthritis risk using genetics, biomarkers, and lifestyle factors to motivate health behavior improvements: A randomized controlled trial, 2018-04-16

• Hydroxychloroquine prescription trends and predictors for excess dosing per recent ophthalmology guidelines, 2018-07-05

• Ambient air pollution exposures and risk of rheumatoid arthritis in the Nurses' Health Study, 2013-02-11

• Being overweight or obese and risk of developing rheumatoid arthritis among women: a prospective cohort study, 2014-07-23

• Increasing Ancestral Diversity in Systemic Lupus Erythematosus Clinical Studies, 2022-01-19

• Arthritis and Use of Hydroxychloroquine Associated with a Decreased Risk of Macrophage Activation Syndrome among Adult Patients Hospitalized with Systemic Lupus Erythematosus, 2018-02-16

• Regional differences regarding risk of developing Rheumatoid Arthritis in Stockholm County, Sweden Results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study, 2013-04-23

• Identification and Validation of Lupus Nephritis Cases Using Administrative Data, 2010-02-23

• Reply, 2020-07-10

• Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women, 2018-08-14

• Atrial Fibrillation/Flutter Hospitalizations among U.S. Medicaid Recipients with and without Systemic Lupus Erythematosus, 2019-11-01

• The Effects of Vitamin D and Marine Omega-3 Fatty Acid Supplementation on Chronic Knee Pain in Older U.S. Adults: Results from a Randomized Trial, 2020-10-03

• Rheumatoid arthritis and risk of chronic obstructive pulmonary disease or asthma among women: a marginal structural model analysis in the Nurses' Health Study, 2017-09-18

• Longitudinal Analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort, 2022-03-25

• Associations between Smoking and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses, 2021-09-24

• Dietary Intake of Vitamin D during Adolescence and Risk of Adult onset Systemic Lupus Erythematosus and Rheumatoid Arthritis, 2012-07-08

• End-Stage Renal Disease due to Lupus Nephritis among Children in the U.S., 1995-2006, 2011-03-22

• Patterns and Predictors of Recurrent Acute Care Use among Medicaid Beneficiaries with Systemic Lupus Erythematosus, 2020-03-02

• Reply, 2019-07-19

• Association of fish intake and smoking with risk of rheumatoid arthritis and age of onset: a prospective cohort study, 2019-01-05

• Circulating Blood Metabolite Trajectories and Risk of Rheumatoid Arthritis among Military Personnel in the Department of Defense Biorepository, 2021-03-22

• Sex Differences in Healthcare Utilization, End-stage Renal Disease and Mortality among Medicaid Beneficiaries with Incident Lupus Nephritis, 2018-02-06

• Prevalence, Incidence and Demographics of Systemic Lupus Erythematosus and Lupus Nephritis among Medicaid-Enrolled U.S. Children, 2000-2004, 2012-03-31

• Prevalence and demographics of systemic lupus erythematosus and lupus nephritis among US children with Medicaid coverage, 2002-2004, 2012-07-13

• Genetic variants atCD28,PRDM1, andCD2/CD58are associated with rheumatoid arthritis risk, 2009-11-08

• Association between Residences in U.S. Northern Latitudes and Rheumatoid Arthritis: A Spatial Analysis of the Nurses' Health Study, 2010-03-25

• Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes, 2022-04-08

• End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated WithAPOL1, 2014-04-14

• Endometriosis and the risks of systemic lupus erythematosus and rheumatoid arthritis in the Nurses' Health Study II, 2015-08-03

• Methodological Considerations in Comparing Access to Pre-emptive Renal Transplantation between SLE and other ESRD causes in the USRDS, 2018-06-12

• Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history, 2014-03-31

• Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes, 2019-08-13

• Racial/Ethnic Variation in All-Cause Mortality among U.S. Medicaid Recipients with Systemic Lupus Erythematosus: An Hispanic and Asian Paradox, 2015-03-10

• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci, 2010-05-09

• Genetic polymorphisms inPTPN22,PADI-4, andCTLA-4and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking, 2008-05-07

• Interactions between amino-acid-defined MHC class II variants and smoking for seropositive rheumatoid arthritis, 2015-07-09

• AMBIENT AIR POLLUTION EXPOSURES AND RISK OF RHEUMATOID ARTHRITIS: RESULTS FROM THE SWEDISH EIRA CASE-CONTROL STUDY, 2012-07-24

• Assessing Improved Risk Prediction of Rheumatoid Arthritis by Environmental, Genetic, and Metabolomic Factors, 2021-07-10

• Cigarette Smoking and the Pathogenesis of Systemic Lupus Erythematosus, 2018-05-11

• Reply, 2019-10-21

• Development and Initial Validation of the Self-Assessed Lupus Damage Index Questionnaire (LDIQ), 2010-02-18

• Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases, 2014-09-02

• Impact of reported NSAID "allergies” on opioid use disorder in back pain, 2020-09-09

• Effects of Vitamin D3and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL Randomized Trial, 2022-12-14

• 2019 EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus, 2019-08-06

• Epidemiology and Sociodemographics of Systemic Lupus Erythematosus and Lupus Nephritis among U.S. Adults with Medicaid Coverage, 2000-2004, 2013-07-11

• Genetic Risk Score Predicting Risk of Rheumatoid Arthritis Phenotypes and Age of Symptom Onset, 2011-09-12

• Personalized Risk Estimator for Rheumatoid Arthritis (PRE-RA) Family Study: Rationale and design for a randomized controlled trial evaluating rheumatoid arthritis risk education to first-degree relatives, 2014-08-20

• Hydroxychloroquine and immunosuppressant adherence patterns and their association with subsequent hospitalization rates among children with systemic lupus erythematosus, 2022-06-08

• Comparative Fracture Risks among US Medicaid Enrollees with and without Systemic Lupus Erythematosus, 2019-06-05

• Reply, 2016-10-14

• Area-level Predictors of Medication Nonadherence among U.S. Medicaid Beneficiaries with Lupus: A Multilevel Study, 2018-07-30

• Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis, 2020-05-27

• Serious Infections among Adult Medicaid Beneficiaries with Systemic Lupus Erythematosus and Lupus Nephritis, 2015-03-05

• Serious infection incidence rates in pediatric systemic lupus erythematosus according to medication use, 2014-09-18

• Early-life exposure to cigarette smoke and adult-onset SLE, 2010-07-27

• Association of trauma and posttraumatic stress disorder with incident systemic lupus erythematosus (SLE) in a longitudinal cohort of women, 2017-10-12

• SEX-SPECIFIC ENVIRONMENTAL INFLUENCES ON THE DEVELOPMENT OF AUTOIMMUNE DISEASES, 2013-02-28

• Development of a Set of Lupus-Specific Ambulatory Care Sensitive, Potentially Preventable Adverse Conditions: A Delphi Consensus Study, 2019-10-21

• A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis, 2009-06-25

• A Combination of Healthy Lifestyle Behaviors Reduces Risk of Incident Systemic Lupus Erythematosus, 2022-01-11

• Variation in Initial Kidney Replacement Therapy for End-Stage Renal Disease Due to Lupus Nephritis in the U.S., 2011-08-24

• Reply, 2021-03-11

• Comparison of the 1987 American College of Rheumatology and the 2010 American College of Rheumatology/European League against Rheumatism Criteria for Classification of Rheumatoid Arthritis in the Nurses' Health Study Cohorts, 2013-09-24

• A prospective study of reproductive factors in relation to risk of systemic lupus erythematosus among black women, 2020-11-24

• Relationship of cigarette smoking and alcohol consumption to incidence of systemic lupus erythematosus in the Black Women's Health Study, 2018-07-19

• Multicriteria Decision Analysis Process to Develop New Classification Criteria for Systemic Lupus Erythematosus, 2019-01-28

• Validation of Systemic Lupus Erythematosus diagnosis as the primary cause of renal failure in the United States Renal Data Systems, 2016-07-13

• Gene-Environment Interaction Between HLA-DRB1 Shared Epitope and Heavy Cigarette Smoking in Predicting Incident RA, 2010-09-07

• Associations Between Daily Alcohol Consumption and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses Without SLE, 2020-06-06

• Depression and subsequent risk for incident rheumatoid arthritis among women, 2020-09-16

• Passive Smoking Throughout the Life Course and the Risk of Incident Rheumatoid Arthritis in Adulthood Among Women, 2021-10-19

• Weight change in the early rheumatoid arthritis period and risk for subsequent mortality among women with RA and matched comparators, 2017-12-07

• Avoidable Acute Care Use for Vaccine-Preventable Illnesses among Medicaid Beneficiaries with Lupus, 2021-08-04

• Azathioprine and Mycophenolate Mofetil Adherence Patterns and Predictors among Medicaid Beneficiaries with Systemic Lupus Erythematosus, 2018-10-23

• Asthma, Chronic Obstructive Pulmonary Disease, and Subsequent Risk for Incident Rheumatoid Arthritis among Women: A Prospective Cohort Study, 2020-04-03

• Medication Nonadherence is Associated with Increased Subsequent Acute Care Utilization among Medicaid Beneficiaries with Systemic Lupus Erythematosus, 2015-06-26

• Comparative Risks of Cardiovascular Disease in Systemic Lupus Erythematosus, Diabetes and General Medicaid Patients, 2020-12-20

• Anti-Citrullinated Peptide Antibody (ACPA) Assays and their Role in the Diagnosis of Rheumatoid Arthritis, 2009-11-15

• Association of Discoid Lupus with other Clinical Manifestations among Patients with Systemic Lupus Erythematosus, 2013-03-28

• Sociodemographics and epidemiology of serious infections requiring hospitalization among adults with systemic lupus erythematosus and lupus nephritis, 2000 to 2006, 2014-09-18

• Reply, 2020-12-05

• TIME TO PROGRESSION FROM DISCOID LUPUS ERYTHEMATOSUS (DLE) TO SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): A RETROSPECTIVE COHORT STUDY, 2019-05-23

• Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus among Women in the Nurses' Health Study Cohorts, 2016-06-16

• Exposure to Traffic Pollution and Increased Risk of Rheumatoid Arthritis, 2009-03-04

• Racial and Ethnic Differences in Mortality and Cardiovascular Events among Patients with End-Stage Renal Disease due to Lupus Nephritis, 2015-04-23

• Immunosenescence and Rheumatoid Arthritis: Does Telomere Shortening Predict Impending Disease?, 2011-05-07

• Prescribing Patterns of Hydroxychloroquine and Corticosteroids Among Lupus Patients After New-onset End-stage Renal Disease, 2022-08-19

• Racial Differences in Contraception Encounters and Dispensing Among Female Medicaid Beneficiaries with Systemic Lupus Erythematosus, 2021-09-02

• Association of Dietary Quality with Risk of Incident Systemic Lupus Erythematosus in the Nurses' Health Studies, 2021-08-06

• Lymphoma risk in systemic lupus: effects of disease activity versus treatment, 2013-01-08

• Association of Ultraviolet-B Radiation and Risk of SLE among Women in the Nurses' Health Studies, 2023-02-23

• Disease Activity and Transition Outcomes in a Childhood-onset Systemic Lupus Erythematosus Cohort, 2016-07-11

• Racial/Ethnic Variation in Stroke Rates and Risks among Patients with Systemic Lupus Erythematosus, 2018-07-31

• Elevated anti-citrullinated protein antibodies prior to rheumatoid arthritis diagnosis and risks for chronic obstructive pulmonary disease or asthma, 2020-01-10

• Circulating Carotenoids and Subsequent Risk of Rheumatoid Arthritis in Women Brief Communication, 2017-01-04

• Serious Infection Rates among Children with Systemic Lupus Erythematosus Enrolled in Medicaid, 2017-09-21

• Developing and Refining New Candidate Criteria for SLE Classification: An International Collaboration, 2018-02-22

• Quality of Care for Incident Lupus Nephritis Among Medicaid Beneficiaries in the United States, 2014-06-13

• Racial Variation in Total Knee Replacement in a Diverse Nationwide Clinical Trial, 2017-10-12

• Comparative Rates of Serious Infections among Patients with Systemic Lupus Erythematosus Receiving Immunosuppressive Medications, 2016-08-25

• The Effects of One Year of Vitamin D and Marine Omega-3 Fatty Acid Supplementation On Biomarkers of Systemic Inflammation in Older U.S. Adults, 2019-11-07

• Reply, 2017-08-22

• Does Vitamin D Affect Risk of Developing Autoimmune Disease?: A Systematic Review, 2010-11-02

• Common variants atCD40and other loci confer risk of rheumatoid arthritis, 2008-09-14

• Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus, 2018-03-28

• The Economic Burden of Systemic Lupus Erythematosus in Commercially- and Medicaid-insured Populations in the United States, 2020-05-23

• Long-term Dietary Quality and Risk of Developing Rheumatoid Arthritis in Women, 2017-01-30

• Monocyte chemotactic protein-1 elevation prior to the onset of rheumatoid arthritis among women, 2015-07-30

• Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures, 2016-06-10

• Understanding the role of environmental factors in the development of Systemic Lupus Erythematosus, 2017-10-21

• Smoking behavior changes in the early rheumatoid arthritis period and risk of mortality during 36 years of prospective follow-up, 2017-12-15

• One-Year Effects of Omega-3 Treatment on Fatty Acids, Oxylipins, and Related Bioactive Lipids and Their Associations with Clinical Lipid and Inflammatory Biomarkers: Findings from a Substudy of the Vitamin D and Omega-3 Trial (VITAL), 2020-10-27

• Reply, 2020-12-20

• Associations of smoking and age with inflammatory joint signs among first-degree relatives without rheumatoid arthritis: Results from the Studies of the Etiology of RA, 2016-11-05

• Heart Failure Risk in Systemic Lupus Erythematosus compared to Diabetes Mellitus and General Medicaid Patients, 2019-06-11

• Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study, 2013-02-04

• Asthma and elevation of anti-citrullinated protein antibodies prior to the onset of rheumatoid arthritis, 2019-11-21

• Impact and timing of smoking cessation on reducing risk for rheumatoid arthritis among women in the Nurses' Health Studies, 2019-01-24

• Early Life Factors and Adult-Onset Rheumatoid Arthritis, 2009-10-15

• Association of Physical Activity with Bioactive Lipids and Cardiovascular Events, 2022-07-19

• Response to "Comment on ‘Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures'”, 2016-11-01

• Designing an Intervention for Women with Systemic Lupus Erythematosus from Medically Underserved Areas to Improve Care: A Qualitative Study, 2012-10-19