Dr. Joshua Denny, MD

• Internal Medicine

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Vanderbilt

  Fellowship Hospital, 2007

• Vanderbilt University School Of Medicine

  Medical School, 2003

• Development of the Initial Surveys for theAll of UsResearch Program, 2019-04-08

• Return of Individual Research Results from Genome-wide Association Studies: Experience of the Electronic Medical Records & Genomics (eMERGE) Network, 2012-02-23

• Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation, 2022-02-26

• The effect of genetic variation in PCSK9 on the LDL-cholesterol response to statin therapy, 2016-02-23

• Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records, 2013-07-18

• Characterization of Statin Dose-response within Electronic Medical Records, 2013-10-04

• Genetic Variants That Confer Resistance to Malaria Are Associated with Red Blood Cell Traits in African-Americans: An Electronic Medical Record-based Genome-Wide Association Study, 2013-07-01

• Leveraging human genetics to identify safety signals prior to drug marketing approval and clinical use, 2020-03-11

• Learning from Longitudinal Data in Electronic Health Record and Genetic Data to Improve Cardiovascular Event Prediction, 2019-01-24

• Using Systems Approaches to Address Challenges for Clinical Implementation of Pharmacogenomics, 2013-12-06

• Limestone: High-throughput candidate phenotype generation via tensor factorization, 2014-07-16

• Admixture Mapping and Subsequent Fine-Mapping Suggests a Biologically Relevant and Novel Association on Chromosome 11 for Type 2 Diabetes in African Americans, 2014-03-03

• Association of Genetic Risk for Obesity with Postoperative Complications Using Mendelian Randomization, 2019-11-09

• Discovery of Noncancer Drug Effects on Survival in Electronic Health Records of Patients With Cancer: A New Paradigm for Drug Repurposing, 2019-07-31

• Evaluation of a Prediction Model for the Development of Atrial Fibrillation in a Repository of Electronic Medical Records, 2016-12-01

• Opportunities for genomic clinical decision support interventions, 2013-09-19

• eMERGEing progress in genomics-the first seven years, 2014-06-17

• Association of ST2 polymorphisms with atopy, asthma and leukemia, 2018-05-19

• Meta-analysis of genome-wide association studies of HDL cholesterol response to statins, 2016-09-01

• High-throughput framework for genetic analyses of adverse drug reactions using electronic health records, 2021-06-01

• Modulators of normal ECG intervals identified in a large electronic medical record, 2010-10-29

• An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical records, 2010-08-03

• Phenome-Wide Association Study of Rheumatoid Arthritis Subgroups Identifies Association between Seronegative Disease and Fibromyalgia, 2016-09-18

• Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population IdentifiesPLB1as a Candidate Rheumatoid Arthritis Risk Gene, 2014-02-10

• Comparison of HLA allelic imputation programs, 2017-02-16

• A prognostic model based on readily available clinical data enriched a preemptive pharmacogenetic testing program, 2015-11-25

• Exome-wide association study of plasma lipids in >300,000 individuals, 2017-10-30

• Phenome-wide association studies demonstrating pleiotropy of genetic variants withinFTOwith and without adjustment for body mass index, 2014-08-05

• Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach, 2022-05-19

• The influence of big (clinical) data and genomics on precision medicine and drug development, 2018-02-05

• Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization, 2014-06-22

• Evaluation of theMC4Rgene across eMERGE network identifies many unreported obesity-associated variants, 2020-09-20

• Computational Phenotype Discovery Using Unsupervised Feature Learning over Noisy, Sparse, and Irregular Clinical Data, 2013-06-24

• The eMERGE Genotype Set of 83,717 Subjects Imputed to ~40 Million Variants Genome Wide and Association with the Herpes Zoster Medical Record Phenotype, 2018-10-08

• Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function, 2016-01-21

• Developing a Data Element Repository to Support EHR-driven Phenotype Algorithm Authoring and Execution, 2016-07-05

• Developing Customizable Cancer Information Extraction Modules for Pathology Reports Using CLAMP, 2019-08-21

• Electronic Medical Records for Genetic Research: Results of the eMERGE Consortium, 2011-04-20

• Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network, 2014-12-01

• Phenome-wide association studies uncover a novel association of increased atrial fibrillation in males with systemic lupus erythematosus, 2018-02-27

• Common variation nearIRF6is associated with IFN-ß induced liver injury in multiple sclerosis, 2018-07-16

• Qualitative study of system level factors related to genomic implementation, 2018-11-23

• Phenotype risk scores identify patients with unrecognized Mendelian disease patterns, 2018-03-16

• High Density GWAS for LDL Cholesterol in African Americans Using Electronic Medical Records Reveals a Strong Protective Variant inAPOE, 2012-08-23

• Using human ‘experiments of nature' to predict drug safety issues: an example with PCSK9 inhibitors, 2017-12-02

• Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational study using electronic health records, 2018-08-28

• ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow, 2015-07-30

• Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins, 2014-10-28

• ATrans-Ethnic Genome-Wide Association Study of Uterine Fibroids, 2019-06-12

• Analyzing Differences between Chinese and English Clinical Text: A Cross-Institution Comparison of Discharge Summaries in Two Languages, 2016-07-19

• Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-wide Association Studies, 2016-04-16

• A Standards-based Semantic Metadata Repository to Support EHR-driven Phenotype Authoring and Execution, 2016-06-03

• Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action, 2015-06-17

• Autoantibodies, autoimmune risk alleles and clinical associations in rheumatoid arthritis cases and non-RA controls in the electronic medical records, 2012-11-30

• A Mendelian Randomization Approach Using 3-HMG-Coenzyme-A Reductase Gene Variation to Evaluate the Association of Statin-Induced Low-Density Lipoprotein Cholesterol Lowering With Noncardiovascular Disease Phenotypes Statin-Induced Low-Density Lipoprotein Cholesterol Lowering and Noncardiovascular Di, 2021-06-07

• Penetrance of Hemochromatosis inHFEGenotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network, 2015-09-10

• CYP2C19 Loss-Of-Function is Associated with Increased Risk of Ischemic Stroke after Transient Ischemic Attack in Intracranial Atherosclerotic Disease, 2020-11-24

• A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record, 2014-12-11

• Mendelian randomization of circulating polyunsaturated fatty acids and colorectal cancer risk, 2020-02-12

• Performance of an electronic health record-based phenotype algorithm to identify community associated methicillin-resistantStaphylococcus aureuscases and controls for genetic association studies, 2016-11-17

• Multi-site Investigation of Outcomes with Implementation ofCYP2C19Genotype-Guided Antiplatelet Therapy after Percutaneous Coronary Intervention, 2017-11-01

• Chapter 13: Mining Electronic Health Records in the Genomics Era, 2012-12-27

• CP Tensor Decomposition with Cannot-Link Intermode Constraints*, 2019-05-14

• Mapping the Incidentalome: Estimating Incidental Findings Generated Through Clinical Pharmacogenomics Testing, 2012-11-29

• Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record, 2019-11-04

• Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network, 2017-05-22

• Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation, 2017-04-17

• A Genome- and Phenome-Wide Association Study to Identify Genetic Variants Influencing Platelet Count and Volume and their Pleiotropic Effects, 2013-09-12

• Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically linksPLCL1to speech language development andIL5-IL13to Eosinophilic Esophagitis, 2014-11-18

• Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, 2017-11-06

• A Robust e-Epidemiology Tool in Phenotyping Heart Failure with Differentiation for Preserved and Reduced Ejection Fraction: the Electronic Medical Records and Genomics (eMERGE) Network, 2015-07-21

• A phenome-wide association study to discover pleiotropic effects ofPCSK9,APOB, andLDLR, 2019-02-11

• Enhancing the Power of Genetic Association Studies through the Use of Silver Standard Cases Derived from Electronic Medical Records, 2013-06-10

• Effects ofG6pc2Deletion on Body Weight and Cholesterol in Mice, 2017-01-25

• eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants, 2016-08-12

• Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders, 2022-06-14

• Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record, 2017-07-07

• Examining Rare and Low-Frequency Genetic Variants Previously Associated with Lone or Familial Forms of Atrial Fibrillation in an Electronic Medical Record System: A Cautionary Note, 2014-11-19

• Diversity and inclusion for theAll of Usresearch program: A scoping review, 2020-07-01

• CYP2C19 Loss-Of-Function Associated with First-time Ischemic Stroke in Non-surgical Asymptomatic Carotid Artery Stenosis during Clopidogrel Therapy, 2021-02-21

• Making work visible for electronic phenotype implementation: lessons learned from the eMERGE network, 2019-09-19

• Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants, 2017-05-10

• Extracting research-quality phenotypes from electronic health records to support precision medicine, 2015-04-30

• Size matters: How population size influences genotype-phenotype association studies in anonymized data, 2014-07-16

• Identifying QT prolongation from ECG impressions using a general-purpose Natural Language Processor, 2008-10-19

• Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans, 2016-06-21

• Rubik: Knowledge Guided Tensor Factorization and Completion for Health Data Analytics, 2019-08-20

• Integrating electronic health record genotype and phenotype datasets to transform patient care, 2016-01-26

• Genetic variation in theUGT1Alocus is associated with simvastatin efficacy in a clinical practice setting, 2015-01-07

• Opportunities and challenges in cardiovascular pharmacogenomics: From discovery to implementation, 2018-04-27

• Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus, 2018-11-26

• The Effect of Reducing Maximum Shift Lengths to 16 Hours on Internal Medicine Interns' Educational Opportunities, 2013-04-10

• Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults, 2017-05-04

• Developing Electronic Health Record Algorithms that Accurately Identify Patients with Systemic Lupus Erythematosus, 2017-04-10

• The Electronic Medical Records and Genomics (eMERGE) Network: Past, Present and Future, 2013-06-06

• A common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women, 2017-06-29

• The phenotypic legacy of admixture between modern humans and Neanderthals, 2016-02-12

• Genome-wide study of resistant hypertension identified from electronic health records, 2017-02-21

• Genetics of rheumatoid arthritis contributes to biology and drug discovery, 2013-12-25

• Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation, 2018-06-11

• Phenome-wide association analysis of LDL-cholesterol lowering genetic variants inPCSK9, 2019-10-29

• Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects, 2019-06-25

• Prototype Development: Context-Driven Dynamic XML Ophthalmologic Data Capture Application, 2017-09-13

• Medical records-based chronic kidney disease phenotype for clinical care and "big data” observational and genetic studies, 2021-04-13

• Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study, 2019-10-18

• Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium, 2017-09-12

• LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanks, 2020-11-11

• LPAvariants are associated with residual cardiovascular risk in patients receiving statins, 2018-10-23

• Multi-ancestry genome- and phenome-wide association studies of diverticular disease in electronic health records with natural language processing enriched phenotyping algorithm, 2023-05-17

• The IGNITE network: a model for genomic medicine implementation and research, 2016-01-05

• Association of arrhythmia-related genetic variants with phenotypes documented in electronic medical records, 2016-01-05

• Operational implementation of prospective genotyping for personalized medicine: The design of the Vanderbilt PREDICT project, 2012-05-16

• Unfolding of hidden white blood cell count phenotypes for gene discovery using latent class mixed modeling, 2018-11-21

• Generating Clinical Notes for Electronic Health Record Systems, 2010-01-01

• Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network, 2018-12-13

• Identifying Lupus Patients in Electronic Health Records: Development and Validation of Machine Learning Algorithms and Application of Rule-Based Algorithms, 2019-01-04

• Discovery of Noncancer Drug Effects on Survival in Electronic Health Records of Patients With Cancer: A New Paradigm for Drug Repurposing, 2019-05-29

• Intelligent Use and Clinical Benefits of Electronic Health Records in Rheumatoid Arthritis, 2015-02-08

• Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways., 2020-02-17

• Facilitating phenotype transfer using a common data model, 2019-07-17

• Clinical phenotyping in selected national networks: demonstrating the need for high-throughput, portable, and computational methods, 2016-06-25

• PregOMICS - leveraging systems biology and bioinformatics for drug repurposing in maternal-child health, 2018-05-04

• Genotype and risk of major bleeding during warfarin treatment, 2015-01-09

• Joint mouse-human phenome-wide association to test gene function and disease risk, 2016-02-02

• Identification of unique venous thromboembolism-susceptibility variants in African-Americans, 2017-02-16

• Phenome-Wide Association Studies as a Tool to Advance Precision Medicine, 2016-05-04

• Attitudes of Clinicians Following Large-Scale Pharmacogenomics Implementation, 2015-08-11

• Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits, 2022-11-11

• Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm, 2015-07-02

• An atlas of genetic variation linking pathogen-induced cellular traits to human disease, 2018-08-08

• Knowledge-Driven Multi-Locus Analysis Reveals Gene-Gene Interactions Influencing HDL Cholesterol Level in Two Independent EMR-Linked Biobanks, 2011-05-11

• An active learning-enabled annotation system for clinical named entity recognition, 2017-07-05

• Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data, 2014-03-20

• TYK2Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits, 2015-04-07

• Tracking medical students' clinical experiences using natural language processing, 2009-02-21

• Design Patterns for the Development of Electronic Health Record-Driven Phenotype Extraction Algorithms, 2014-06-21

• Genome- and Phenome-Wide Analysis of Cardiac Conduction Identifies Markers of Arrhythmia Risk, 2013-03-05

• Trans-ethnic association study of blood pressure determinants in over 750,000 individuals, 2018-12-21

• Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions, 2016-04-27

• Analyses of longitudinal, hospital clinical laboratory data with application to blood glucose concentrations, 2011-09-21

• Translational Health Disparities Research in a Data-Rich World, 2019-11-08

• A Comparison of Rule-Based and Machine Learning Approaches for Classifying Patient Portal Messages, 2017-06-23

• Development of a System for Post-marketing Population Pharmacokinetic and Pharmacodynamic Studies using Real-World Data from Electronic Health Records, 2020-02-11

• Biobanks and Electronic Medical Records: Enabling Cost-Effective Research, 2014-04-30

• A gene-based association method for mapping traits using reference transcriptome data, 2015-08-10

• Development of Inpatient Risk Stratification Models of Acute Kidney Injury for Use in Electronic Health Records, 2010-03-30

• Enabling Genomic-Phenomic Association Discovery without Sacrificing Anonymity, 2013-02-06

• Research directions in the clinical implementation of pharmacogenomics - An Overview of US programs and projects, 2018-03-30

• Detecting Time-Evolving Phenotypic Topics via Tensor Factorization on Electronic Health Records: Cardiovascular Disease Case Study, 2019-08-22

• Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations, 2017-05-12

• Applying Semantic-based Probabilistic Context-Free Grammar to Medical Language Processing - A Preliminary Study on Parsing Medication Sentences, 2011-08-12

• PCSK9genetic variants and risk of type 2 diabetes: a mendelian randomisation study, 2017-02-01

• Defining Phenotypes from Clinical Data to Drive Genomic Research, 2018-04-25

• Natural Language Processing Improves Identification of Colorectal Cancer Testing in the Electronic Health Record, 2011-03-10

• Replication ofSCN5AAssociations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies, 2014-11-24

• Calcium Channel Blockers as Drug Repurposing Candidates for Gestational Diabetes: Mining large scale genomic and electronic health records data to repurpose medications, 2018-02-12

• Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records, 2010-08-12

• A Study of Active Learning Methods for Named Entity Recognition in Clinical Text, 2015-09-15

• Author Correction: Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits, 2023-02-06

• Benefit of pre-emptive pharmacogenetic information on clinical outcome, 2018-03-13

• Design and Anticipated Outcomes of the eMERGE-PGx Project: A Multi-Center Pilot for Pre-Emptive Pharmacogenomics in Electronic Health Record Systems, 2014-06-24

• Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus, 2018-04-10

• An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies, 2018-01-29

• CYP2C19andCES1polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease, 2015-11-20

• Genetic Determinants of Variability in Warfarin Response after the Dose-Titration Phase, 2016-11-04

• Identifying genetically driven clinical phenotypes using linear mixed models, 2016-04-25

• Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol, 2019-05-23

• Generalization of Variants Identified by Genome-wide Association Studies for Electrocardiographic Traits in African Americans, 2013-03-28

• Influence of HLA alleles and KIR types on Heparin-Induced Thrombocytopenia, 2017-09-04

• Association between triglycerides, known risk SNVs and conserved rare variation inSLC25A40in a multi-ancestry cohort, 2021-01-06

• Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans, 2017-03-28

• Phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank study, 2019-09-13

• The polygenic architecture of left ventricular mass mirrors the clinical epidemiology, 2020-05-05

• Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies, 2018-08-13

• Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis, 2022-11-04

• A Common Variant on Chromosome 4q25 is Associated With Prolonged PR Interval in Subjects With and Without Atrial Fibrillation, 2013-10-03

• Using topic modeling via non-negative matrix factorization to identify relationships between genetic variants and disease phenotypes: A case study of Lipoprotein(a) (LPA), 2019-02-13

• SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation, 2017-12-18

• Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record, 2012-02-13

• Pulling the covers in electronic health records for an association study with self-reported sleep behaviors, 2018-09-05