Dr. Jonathan Mosley, MD

• Internal Medicine

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• Case Western Reserve University

  Medical School, 2009

• Arrhythmia variant associations and reclassifications in the eMERGE-III sequencing study, 2021-12-21

• Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer, 2017-01-31

• Using Systems Approaches to Address Challenges for Clinical Implementation of Pharmacogenomics, 2013-12-06

• Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile using Historical Data, 2016-10-25

• The polygenic architecture of left ventricular mass mirrors the clinical epidemiology, 2020-05-05

• Identifying genetically driven clinical phenotypes using linear mixed models, 2016-04-25

• Influence of HLA alleles and KIR types on Heparin-Induced Thrombocytopenia, 2017-09-04

• Mechanistic Phenotypes: An Aggregative Phenotyping Strategy to Identify Disease Mechanisms Using GWAS Data, 2013-12-12

• Intrinsic bias in breast cancer gene expression data sets, 2009-06-29

• Integrating EMR-Linked andIn VivoFunctional Genetic Data to Identify New Genotype-Phenotype Associations, 2014-06-20

• Cell cycle correlated genes dictate the prognostic power of breast cancer gene lists, 2008-04-25

• LPAvariants are associated with residual cardiovascular risk in patients receiving statins, 2018-10-23

• Phenome-wide association studies demonstrating pleiotropy of genetic variants withinFTOwith and without adjustment for body mass index, 2014-08-05

• Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk, 2021-03-08

• Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: a phenome-wide association study and inverse-variance weighted meta-analysis, 2021-05-12

• Genome-wide approach to measure variant-based heritability of drug outcome phenotypes, 2021-07-12

• A Mendelian Randomization Approach Using 3-HMG-Coenzyme-A Reductase Gene Variation to Evaluate the Association of Statin-Induced Low-Density Lipoprotein Cholesterol Lowering With Noncardiovascular Disease Phenotypes Statin-Induced Low-Density Lipoprotein Cholesterol Lowering and Noncardiovascular Di, 2021-06-07

• Biobanks and Electronic Medical Records: Enabling Cost-Effective Research, 2014-04-30

• Association Between Low-Density Lipoprotein Cholesterol Levels and Risk for Sepsis Among Patients Admitted to the Hospital With Infection Association of LDL-C Levels and Sepsis Risk Among Patients With Infection, 2019-01-18

• Identifying potential therapeutic applications and diagnostic harms of increased bilirubin concentrations - a clinical and genetic approach, 2021-10-24

• Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa, 2022-04-05

• Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational study using electronic health records, 2018-08-28

• Predictive Accuracy of a Polygenic Risk Score for Postoperative Atrial Fibrillation After Cardiac Surgery, 2021-03-01

• Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission, 2017-11-11

• Opportunities and challenges in cardiovascular pharmacogenomics: From discovery to implementation, 2018-04-27

• Replication and fine-mapping of genetic predictors of lipid traits in African-Americans, 2017-05-25

• Genetic susceptibility for autoimmune diseases and white blood cell count, 2023-04-11

• Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease, 2021-01-13

• Comparison of HLA allelic imputation programs, 2017-02-16

• Association between Low-Density Lipoprotein Cholesterol Levels and Risk for Sepsis among Patients Admitted to the Hospital with Infection, 2019-01-04

• Benefit of pre-emptive pharmacogenetic information on clinical outcome, 2018-03-13

• Phenotype risk scores identify patients with unrecognized Mendelian disease patterns, 2018-03-16

• Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease, 2019-12-03

• The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with theSH2B3gene, 2021-08-02

• A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers, 2018-08-30

• Limited clinical utility for GWAS or polygenic risk score for postoperative acute kidney injury in non-cardiac surgery in European-ancestry patients, 2022-10-21

• Genetically adjusted PSA levels for prostate cancer screening, 2023-06-01

• Exome Sequencing Implicates an Increased Burden of Rare Potassium Channel Variants in the Risk of Drug Induced Long QT Syndrome, 2014-02-19

• Probing the virtual proteome to identify novel disease biomarkers, 2018-11-27

• Genotype-based "virtual” metabolomics in a clinical biobank identifies novel metabolite-disease associations, 2023-10-11

• A Genome-Wide Association Study Identifies Variants inKCNIP4Associated with ACE Inhibitor Induced Cough, 2015-07-14

• Investigating the Genetic Architecture of the PR Interval using Clinical Phenotypes, 2017-03-23

• A Polygenic Risk Score to Identify Subclinical Coronary Heart Disease Risk in Young Adults, 2021-08-31

• Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults, 2017-05-04

• Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype, 2021-09-20

• Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis - a phenome-wide association study and inverse-variance weighted meta-analysis, 2020-08-06

• Clinical Features Associated with Nascent Left Ventricular Diastolic Dysfunction in a Population Aged 40-55 Years, 2018-03-13

• Frequency of benign neutropenia among Black versus White individuals undergoing a bone marrow assessment, 2022-06-01

• Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome, 2020-04-11

• A metabolome and microbiome wide association study of healthy eating index points to the mechanisms linking dietary pattern and metabolic status, 2021-05-31

• Lossless integration of multiple electronic health records for identifying pleiotropy using summary statistics, 2021-01-08