Dr. John Perfect, MD

• Infectious Disease Medicine

• Internal Medicine

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Duke University Medical Center

  Residency Hospital

• Riverside Methodist Hospital

  Residency Hospital

• University Of Mi Hosps And Health Ctrs

  Residency Hospital

• University Of Toledo College Of Medicine And Life Sciences

  Medical School

• Titan cells formation inCryptococcus neoformansis finely tuned by environmental conditions and modulated by positive and negative genetic regulators, 2018-05-18

• Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidemia, 2014-09-08

• Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium, 2019-12-05

• Cryptococcus neoformansIs Resistant to Surfactant Protein A Mediated Host Defense Mechanisms, 2007-12-26

• Copy number variation contributes to cryptic genetic variation in outbreak lineages ofCryptococcus gattiifrom the North American Pacific Northwest, 2016-09-02

• Editorial: Antifungal Pipeline: Build It Strong; Build It Better!, 2022-03-16

• Next Generation Multilocus Sequence Typing (NGMLST) and the Analytical Software Program MLSTEZ Enable Efficient, Cost-Effective, High-Throughput, Multilocus Sequencing Typing, 2015-01-24

• Isavuconazole treatment for rare fungal diseases and for invasive aspergillosis in patients with renal impairment: Challenges and lessons of the VITAL trial, 2018-04-19

• In VitroandIn VivoEvaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus Shaw et al., 2018-07-27

• Identification of Genes from the Fungal PathogenCryptococcus neoformansRelated to Transmigration into the Central Nervous System, 2012-09-20

• First Reported Case ofCryptococcus gattiiin the Southeastern USA: Implications for Travel-Associated Acquisition of an Emerging Pathogen, 2009-06-10

• Genetic Susceptibility to Fungal Infections: What is in the Genes?, 2016-03-29

• The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense againstCandidainfections, 2015-01-13

• On-demand release ofCandida albicansbiofilms from urinary catheters by mechanical surface deformation, 2018-06-13

• Taming Amphotericin B, 2015-09-10

• Defining Responses to Therapy and Study Outcomes in Clinical Trials of Invasive Fungal Diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer Consensus Criteria, 2008-09-01

• Pleiotropic Effects of Deubiquitinating Enzyme Ubp5 on Growth and Pathogenesis ofCryptococcus neoformans, 2012-06-14

• The Hsp90 Co-Chaperone Sgt1 GovernsCandida albicansMorphogenesis and Drug Resistance, 2012-09-06

• ß-D-glucan Surveillance with Preemptive Anidulafungin for Invasive Candidiasis in Intensive Care Unit Patients: A Randomized Pilot Study, 2012-08-06

• Pulmonary blastomycosis presenting as primary lung cancer, 2018-07-18

• Population genomics and the evolution of virulence in the fungal pathogenCryptococcus neoformans Evolution of virulence inCryptococcus neoformans, 2017-07-01

• Functional genomics identifies type I interferon pathway as central for host defense againstCandida albicans, 2013-03-06

• Very Low Levels of 25-Hydroxyvitamin D Are Not Associated With Immunologic Changes or Clinical Outcome in South African Patients With HIV-Associated Cryptococcal Meningitis, 2014-05-13

• Use of Antifungal Combination Therapy: Agents, Order, and Timing, 2010-05-01

• Tracing Genetic Exchange and Biogeography ofCryptococcus neoformansvar.grubiiat the Global Population Level, 2017-07-05

• Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis, 2008-06-20

• MSG07: An International Cohort Study Comparing Epidemiology and Outcomes of Patients withCryptococcus neoformansorCryptococcus gattiiinfections, 2021-10-05

• Cryptococcus neoformansresists to drastic conditions by switching to viable but non-culturable cell phenotype, 2019-07-29

• Trehalose-6-Phosphate Phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogenAspergillus fumigatus, 2010-06-09

• Posaconazole ExhibitsIn VitroandIn VivoSynergistic Antifungal Activity with Caspofungin or FK506 againstCandida albicans, 2013-03-05

• Metabolic adaptation inCryptococcus neoformansduring early murine pulmonary infection, 2008-07-30

• Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America, 2010-02-01

• Role of autophagy genetic variants for the risk ofCandidainfections, 2014-04-08

• Analysis of the Genome and Transcriptome ofCryptococcus neoformansvar.grubiiReveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation, 2014-04-17

• Phenotypic Variability Correlates with Clinical Outcome inCryptococcusIsolates Obtained from Botswanan HIV/AIDS Patients Fernandes et al., 2018-10-23

• Cryptococcosis in Solid Organ Transplant Recipients: Current State-of-the-Science, 2008-11-15

• Transcriptional Profiles Elucidate Differential Host Responses to Infection withCryptococcus neoformansandCryptococcus gattii, 2022-04-22

• Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis, 2023-10-01

• Deletion ofCryptococcus neoformansAIF Ortholog Promotes Chromosome Aneuploidy and Fluconazole-Resistance in a Metacaspase-Independent Manner, 2011-11-17

• AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial, 2015-06-17

• Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence, 2021-04-27

• Efficacy of an Abbreviated Induction Regimen of Amphotericin B Deoxycholate for Cryptococcal Meningoencephalitis: 3 Days of Therapy Is Equivalent to 14 Days, 2014-01-28

• Cryptococcosis Diagnosis and Treatment: What Do We Know Now, 2014-10-13

• Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis Lestner et al., 2017-05-24

• Variation in chromosome copy number influences the virulence ofCryptococcus neoformansand occurs in isolates from AIDS patients, 2011-10-27

• Invasive candidiasis: Investigational drugs in the clinical development pipeline and mechanisms of action, 2022-06-15

• Associations betweenCryptococcusGenotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review, 2021-03-30

• The antifungal pipeline: a reality check, 2017-05-12

• Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant, 2012-08-24

• Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology-oncology patients: a retrospective cohort study, 2014-03-19

• Hsp90 Governs Echinocandin Resistance in the Pathogenic YeastCandida albicansvia Calcineurin, 2009-07-31

• Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome, 2022-11-10

• Familial Adenomatous Polyposis Manifesting asLactococcusEndocarditis: A Case Report and Review of the Association ofLactococcuswith Underlying Gastrointestinal Disease, 2016-10-12

• Microevolution of Serial Clinical Isolates ofCryptococcus neoformansvar.grubiiandC. gattii Chen et al., 2017-03-07

• An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility, 2017-07-20

• Brain Inositol Is a Novel Stimulator for PromotingCryptococcusPenetration of the Blood-Brain Barrier, 2013-04-04

• Pharmacodynamics of Isavuconazole in a Rabbit Model of Cryptococcal Meningoencephalitis Kovanda et al., 2019-08-23

• The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic FungusCryptococcus neoformans Caza et al., 2016-01-13

• PKC Signaling Regulates Drug Resistance of the Fungal PathogenCandida albicansvia Circuitry Comprised of Mkc1, Calcineurin, and Hsp90, 2010-08-26

• Genomic Characterization of Recurrent Mold Infections in Thoracic Transplant Recipients, 2018-06-19

• Cryptococcus gattii:an emerging fungal pathogen infecting humans and animals, 2011-06-01