Dr. Jaffer Ajani, MD

• Medical Oncology

• Internal Medicine

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• Nagpur University / Jawaharlal Nehru Medical College

  Medical School, 1971

• Fusobacterium nucleatumconfers chemoresistance by modulating autophagy in oesophageal squamous cell carcinoma, 2020-12-10

• Clinically conserved genomic subtypes of gastric adenocarcinoma, 2023-09-06

• Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer, 2016-09-21

• GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma, 2022-08-23

• Long non-coding RNAs are significantly associated with prognosis and response to therapies in gastric cancer, 2021-06-06

• Programmed death ligand-1 expression in gastrointestinal cancer: Clinical significance and future challenges, 2020-06-11

• ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade, 2018-05-07

• Severe Lymphopenia During Neoadjuvant Chemoradiation for Esophageal Cancer: A Propensity Matched Analysis of the Relative Risk of Proton versus Photon-Based Radiation Therapy, 2017-12-14

• The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective, 2019-11-27

• Celiac Node Failure Patterns After Definitive Chemoradiation for Esophageal Cancer in the Modern Era, 2012-03-19

• Risk assessment of esophageal adenocarcinoma using ?-H2AX assay, 2013-07-31

• Low metabolic activity in primary gastric adenocarcinoma is associated with resistance to chemoradiation and the presence of signet ring cells, 2020-05-14

• Predictors of Postoperative Complications After Trimodality Therapy for Esophageal Cancer, 2013-08-01

• Obesity and Outcomes in Patients Treated with Chemoradiotherapy for Esophageal Carcinoma, 2013-04-26

• Treatment Patterns for Gastroesophageal Junction Adenocarcinoma in the United States†, 2020-10-29

• Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer, 2022-03-23

• Cancer stem cells in esophageal cancer and response to therapy, 2018-10-25

• Evolution of gastric surgery techniques and outcomes, 2016-07-26

• Drug resistance and Cancer stem cells, 2021-02-15

• Impact of tumor regression grade on recurrence after preoperative chemoradiation and gastrectomy for gastric cancer, 2020-05-27

• Association between adjuvant chemotherapy and survival in patients with rectal cancer and pathological complete response after neoadjuvant chemoradiotherapy and resection, 2020-07-29

• A new intronic quantitative PCR method led to the discovery of transformation from human ascites to murine malignancy in a mouse model, 2023-02-06

• Outcome of Trimodality-Eligible Esophagogastric Cancer Patients Who Declined Surgery after Preoperative Chemoradiation, 2012-09-04

• Preoperatively Treated Diffuse-Type Gastric Adenocarcinoma: Glucose vs. Other Energy Sources Substantially Influence Prognosis and Therapy Response, 2021-01-23

• Phase I study of DFP-11207, a novel oral fluoropyrimidine with reasonable AUC and low Cmaxand improved tolerability, in patients with solid tumors, 2020-05-06

• Nodal Downstaging in Gastric Cancer Patients: Promising Survival if ypN0 is Achieved, 2018-05-10

• Brain metastasis in patients with upper gastrointestinal cancer is associated with proximally located adenocarcinoma and lymph node metastasis, 2020-04-28

• Laparoscopic HIPEC for low-volume peritoneal metastasis in gastric and gastroesophageal adenocarcinoma, 2020-07-31

• Staging laparoscopy and peritoneal cytology in patients with early stage gastric adenocarcinoma, 2020-02-17

• YAP1 Mediates Gastric Adenocarcinoma Peritoneal Metastases that are Attenuated by YAP1 Inhibition, 2020-04-27

• Racial disparities in preoperative chemotherapy use in gastric cancer patients in the United States: Analysis of National Cancer Database 2006-2014, 2018-02-02

• A Novel YAP1 Inhibitor targets CSCs-enriched Radiation Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma, 2017-11-22

• Loss of TGF-ß Adaptor ß2SP Activates Notch Signaling and SOX9 Expression in Esophageal Adenocarcinoma, 2013-03-27

• Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma, 2021-01-04

• Early metabolic change after induction chemotherapy predicts histologic response and prognosis in patients with esophageal cancer: Secondary analysis of a randomized trial, 2017-12-09

• Serum miR-331-3p predicts tumor recurrence in esophageal adenocarcinoma, 2018-09-18

• Concurrent lymphovascular and perineural invasion after preoperative therapy for gastric adenocarcinoma is associated with decreased survival, 2021-01-05

• Challenges and opportunities associated with the MD Anderson IMPACT2 randomized study in precision oncology, 2022-10-27

• Proton Beam Therapy and concurrent chemotherapy for esophageal cancer, 2012-03-13

• The ypT category does not impact overall survival in node negative gastric cancer, 2018-06-27

• Prognostic Biomarkers for Esophageal Adenocarcinoma Identified by Analysis of Tumor Transcriptome, 2010-11-30

• Preoperative Chemoradiation Therapy Induces Primary-tumor Complete Response More Frequently Than Chemotherapy Alone in Gastric Cancer: Analyses of the National Cancer Database 2006-2014 using Propensity Score Matching, 2018-05-05

• Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma S. Songet al., 2020-04-07

• An improved strategy for CRISPR/Cas9 gene knockout and subsequent wildtype and mutant gene rescue, 2020-02-13

• Patient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma, 2021-06-23

• Initial Standardized Uptake Value (iSUV) of Positron Emission Tomography Influences Prognosis of Patients with Localized Gastric Adenocarcinoma Treated Preoperatively, 2015-09-23

• The proportion of signet ring cell component in patients with localized gastric adenocarcinoma correlates with the degree of response to preoperative chemoradiation, 2016-04-06

• The Long Noncoding RNACCAT2induces chromosomal instability through BOP1 - AURKB signaling, 2020-08-15

• LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma, 2019-10-10

• Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer, 2020-10-26

• A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-ß Superfamily, 2018-09-26

• Anal Carcinoma: Impact of TN Category of Disease on Survival, Disease Relapse, and Colostomy Failure in US Gastrointestinal Intergroup RTOG 98-11 Phase 3 Trial, 2013-09-10

• Propensity score based comparison of long term outcomes with 3D conformal radiotherapy (3DCRT) versus Intensity Modulated Radiation Therapy (IMRT) in the treatment of esophageal cancer, 2012-08-03

• An Update on Modern Approaches to Localized Esophageal Cancer, 2014-06-15

• The DNA endonuclease Mus81 regulates ZEB1 expression and serves as a target of BET4 inhibitors in gastric cancer, 2019-05-29

• Final Results of NRG Oncology RTOG 0246: An Organ Preserving Selective Resection Strategy in Esophageal Cancer Patients Treated with Definitive Chemoradiation, 2016-10-08

• AGUIA: autonomous graphical user interface assembly for clinical trials semantic data services, 2010-10-26

• ERCC1andERCC2Variants Predict Survival in Gastric Cancer Patients, 2013-09-02

• Can PD-L1 expression evaluated by biopsy sample accurately reflect its expression in the whole tumour in gastric cancer?, 2019-07-09

• Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma, 2017-02-23

• Identification of Serum Markers of Esophageal Adenocarcinoma by Global and Targeted Metabolic Profiling, 2015-05-19

• Evaluation of the American Joint Committee on Cancer 8th edition staging system for gastric cancer patients after preoperative therapy, 2017-06-22

• Association of Aurora-A (STK15) Kinase Polymorphisms With Clinical Outcome of Esophageal Cancer Treated With Preoperative Chemoradiation, 2011-12-27

• The Significance of Co-Expression of Epidermal Growth Factor Receptor (EGFR) and Ki67 on Clinical Outcome in Patients with Anal Cancer Treated with Chemoradiotherapy: An Analysis of NRG Oncology RTOG 9811, 2016-11-23

• Correction to: LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma, 2021-03-25

• Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma-Rationale for targeting ARID1A deficiency, 2021-03-30

• ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer, 2015-07-17

• Clinical significance of four molecular subtypes of gastric cancer identified by The Cancer Genome Atlas project, 2017-08-01

• SOURCE: A Registry-Based Prediction Model for Overall Survival in Patients with Metastatic Oesophageal or Gastric Cancer, 2019-02-05

• Evaluating Alternative Ramucirumab Doses as a Single Agent or with Paclitaxel in Second-Line Treatment of Locally Advanced or Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma: Results from Two Randomized, Open-Label, Phase II Studies, 2022-02-24

• ARID1A mutation may define an immunologically active subgroup in patients with microsatellite-stable colorectal cancer, 2021-01-07

• LncRNA PVT1 Is a Poor Prognosticator and Can Be Targeted by PVT1 Antisense Oligos in Gastric Adenocarcinoma, 2020-10-15

• Relationship between Initial Management Strategy and Survival in Patients with Gastric Outlet Obstruction due to Gastric Cancer, 2020-08-18

• Barrett's Esophagus After Bimodality Therapy in Patients With Esophageal Adenocarcinoma, 2018-05-29

• Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype, 2018-05-03

• Medical management of gastric cancer: a 2017 update, 2017-12-13

• Zolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial, 2023-07-31

• Recent advances in preoperative management of esophageal adenocarcinoma [version 1; referees: 2 approved], 2017-04-18

• Intensity-Modulated Proton Therapy Further Reduces Normal-Tissue Exposure During Definitive Therapy for Locally Advanced Distal Esophageal Tumors: A Dosimetric Study, 2011-04-04

• Clinical Features and Survival of Gastric Cancer Patients with DNA Mismatch Repair Deficiency, 2017-12-11