Dr. Frederick Lang Jr, MD

• Neurosurgery

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• Yale University

  Medical School, 1988

• Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors, 2020-11-05

• A high Notch pathway activation predicts response to ? secretase inhibitors in proneural subtype of glioma tumor initiating cells, 2013-11-16

• A dexamethasone-regulated gene signature is prognostic for poor survival in glioblastoma patients, 2016-08-24

• Genetic, epigenetic, and molecular landscapes of multifocal and multicentric glioblastoma, 2015-09-01

• Medium-chain acyl CoA dehydrogenase protects mitochondria from lipid peroxidation in glioblastoma, 2021-05-26

• A gene expression signature predicts recurrence-free survival in meningioma, 2018-02-15

• ESI-MS/MS and MALDI-IMS Localization Reveal Alterations in Phosphatidic Acid, Diacylglycerol, and DHA in Glioma Stem Cell Xenografts, 2015-04-29

• Oncolytic adenovirus and tumor-targeting immune modulatory therapy improve autologous cancer vaccination, 2017-05-31

• Ionizing radiation augments glioma tropism of mesenchymal stem cells, 2017-03-31

• Oncolytic adenovirus research evolution: from cell-cycle checkpoints to immune checkpoints, 2015-04-13

• A History of the AANS/CNS Section on Tumors Biennial Satellite Symposium, 2014-08-01

• Circadian regulator CLOCK recruits immune suppressive microglia into the GBM tumor microenvironment, 2020-01-09

• REST regulates oncogenic properties of glioblastoma stem cells, 2013-11-20

• The role of resting-state functional MRI for clinical preoperative language mapping, 2020-07-11

• Two mature products ofMIR-491coordinate to suppress key cancer hallmarks in glioblastoma, 2014-04-21

• Integrated Transcriptomic and Glycomic Profiling of Glioma Stem Cell Xenografts, 2015-08-04

• A co-clinical radiogenomic validation study - Conserved magnetic resonance radiomic appearance of Periostin expressing Glioblastoma in patients and xenograft models, 2018-07-27

• NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors, 2021-10-01

• Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas, 2019-08-27

• Impact of anesthesia and analgesia techniques on glioblastoma progression. A narrative review, 2020-09-16

• Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles, 2023-04-04

• Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial, 2023-05-15

• Multiomics analyses revealDARS1-AS1/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance, 2023-08-01

• A Prospective Randomized Trial of Peri-Operative Seizure Prophylaxis in Patients with Intraparenchymal Brain Tumors, 2013-02-08

• Atrxinactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling, 2018-03-13

• Author Correction:Atrxinactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling, 2022-01-05

• Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells, 2021-10-21

• OTME-23. Single-cell transcriptomic and epigenomic immune landscape of isocitrate dehydrogenase stratified human gliomas, 2021-07-05

• GITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory, 2019-06-05

• Delta-24-RGD Oncolytic Adenovirus Elicits Anti-Glioma Immunity in an Immunocompetent Mouse Model, 2014-05-14

• Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity, 2023-06-27

• TGF-ß Mediates Homing of Bone Marrow-Derived Human Mesenchymal Stem Cells to Glioma Stem Cells, 2013-01-30

• Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance, 2021-10-01

• FoxM1 Drives a Feed-forward STAT3-activation Signaling Loop that Promotes the Self-renewal and Tumorigenicity of Glioblastoma Stem-like Cells, 2015-04-01

• Glioblastoma-mediated immune dysfunction limits CMV-specific T cells and therapeutic responses; results from a Phase I/II trial, 2020-04-16

• A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities, 2020-06-10

• Efficacy of Onalespib a Long-acting Second Generation HSP90 Inhibitor as a Single Agent and in Combination with Temozolomide against Malignant Gliomas, 2017-07-05

• Magnetic Resonance and Photoacoustic Imaging of Brain Tumors Using Carotid Artery Injection of Mesenchymal Stem Cells Labeled with a Multifunctional Nanoparticle, 2018-04-20

• Genetic and Epigenetic Modifications of Sox2 Contribute to the Invasive Phenotype of Malignant Gliomas, 2011-11-01

• Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target, 2022-02-09