Dr. David Wolk, MD

• Neurology

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• ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration, 2020-11-23

• Arterial Spin Labeling MRI: An Emerging Biomarker for Alzheimer's Disease and Other Neurodegenerative Conditions, 2013-04-17

• TMEM106BEffect on Cognition in Parkinson's Disease and Frontotemporal Dementia, 2019-12-24

• Whole-brain background-suppressed pCASL MRI with 1D-accelerated 3D RARE Stack-Of-Spirals readout, 2017-08-24

• Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex, 2018-03-23

• Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy, 2021-03-25

• Effect of Age on Clinical Trial Outcome in Participants with Probable Alzheimer's Disease Age Effects on Clinical Outcome in AD Trials, 2021-06-16

• Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease, 2021-12-02

• Direct Comparison of FDG-PET and ASL-MRI in Alzheimer's Disease, 2011-10-21

• Fractionating Verbal Episodic Memory in Alzheimer's Disease, 2010-09-09

• Disentangling Alzheimer's disease neurodegeneration from typical brain ageing using machine learning, 2022-05-07

• Associative memory for conceptually unitized word pairs in mild cognitive impairment is related to the volume of the perirhinal cortex, 2018-12-26

• Signature laminar distributions of pathology in frontotemporal lobar degeneration, 2022-01-08

• Approach to atypical Alzheimer's disease and case studies of the major subtypes, 2017-02-15

• Astrocyte Activation Imaging with11C-Acetate and Amyloid PET in Mild Cognitive Impairment due to Alzheimer Pathology, 2021-11-01

• Multimodality Imaging of Alzheimer Disease and Other Neurodegenerative Dementias, 2014-11-20

• The Brain Chart of Aging: Machine learning analytics reveals links between brain aging, white matter disease, amyloid burden and cognition in the iSTAGING consortium of 10,216 harmonized MR scans, 2020-09-13

• Left Posterior Parietal Cortex Participates in Both Task Preparation and Episodic Retrieval, 2009-03-10

• Non-Tremor Motor Dysfunction in Lewy Body Dementias is Associated with AD Biomarkers, 2022-06-08

• ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease, 2022-12-26

• Task-Enhanced Arterial Spin Labeled Perfusion MRI Predicts Longitudinal Neurodegeneration in Mild Cognitive Impairment, 2018-11-06

• Genome-wide association study and functional validation implicates JADE1 in tauopathy, 2021-11-01

• Integration and relative value of biomarkers for prediction of MCI to AD progression: Spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers, 2013-11-28

• Amyloid Imaging in Atypical Presentations of Alzheimer's Disease, 2013-12-03

• Association betweenin vivo[18F]-flutemetamol amyloid PET imaging andin vivocerebral cortical histopathology, 2011-07-11

• Diagnostic effectiveness of quantitative [18F]flutemetamol PET imaging for detection of fibrillar amyloid ß using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus, 2014-04-22

• Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI, 2017-11-20

• Characterizing Anatomical Variability And Alzheimer's Disease Related Cortical Thinning in the Medial Temporal Lobe Using Graph-Based Groupwise Registration And Point Set Geodesic Shooting, 2018-11-23

• Neuropsychological Testing Predicts Cerebrospinal Fluid Aß in Mild Cognitive Impairment (MCI), 2015-09-26

• Automated Multi-Atlas Segmentation of Hippocampal and Extrahippocampal Subregions in Alzheimer's Disease at 3T and 7T: What Atlas Composition Works Best?, 2019-04-08

• Links between autobiographical memory richness and temporal discounting in older adults, 2020-04-14

• A deep learning framework identifies dimensional representations of Alzheimer's Disease from brain structure, 2021-12-03

• Discrimination and Reliance on Conceptual Fluency Cues are Inversely Related in Patients with Mild Alzheimer's Disease, 2009-03-04

• Neocortical Origin and Progression of Grey Matter Atrophy In Non-Amnestic Alzheimer's Disease, 2017-11-21

• The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology, 2021-05-21

• Resilient Brain Aging: Characterization of Discordance between Alzheimer's Disease Pathology and Cognition, 2014-04-24

• Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer's disease, 2022-03-21

• Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial Blood Pressure Control and Changes in Cerebral Small Vessel Disease Biomarkers, 2023-03-01

• Prevalence of Amyloid-ß Pathology in Distinct Variants of Primary Progressive Aphasia, 2018-12-07

• Automated hippocampal subfield segmentation at 7 tesla MRI, 2016-02-04

• Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease, 2019-04-29

• Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation, 2020-05-29

• Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease, 2022-12-14

• Association of Plasma C-Reactive Protein Levels with Diagnosis of Alzheimer's Disease, 2013-08-23

• Multi-template analysis of human perirhinal cortex in brain MRI: Explicitly accounting for anatomical variability, 2016-10-01

• In-vivo Measures of Tau Burden are Associated with Atrophy in Early Braak Stage Medial Temporal Lobe Regions in Amyloid Negative Individuals, 2019-09-06

• Accounting for the Confound of Meninges in Segmenting Entorhinal and Perirhinal Cortices in T1-Weighted MRI, 2016-10-02

• Fornix-Region Deep Brain Stimulation-Induced Memory Flashbacks in Alzheimer's Disease, 2019-08-22

• Divergent Patterns of TDP-43 and Tau Pathologies in Primary Progressive Aphasia, 2019-03-28

• Odor Identification Screening Improves Diagnostic Classification in Incipient Alzheimer's Disease, 2017-01-07

• CSF a-synuclein contributes to the differential diagnosis of Alzheimer disease, 2018-03-28

• DeepAtrophy: Teaching a neural network to detect progressive changes in longitudinal MRI of the hippocampal region in Alzheimer's disease, 2021-08-24

• CSF Apo-E levels associate with cognitive decline and MRI changes, 2014-01-03

• Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes, 2022-05-04

• A Medial Temporal Lobe Division of Labor: Insights from Memory in Aging and Early Alzheimer Disease, 2010-04-29

• Recognition memory in amnestic-mild cognitive impairment: insights from event-related potentials, 2013-12-11

• Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampal volume with spinal fluid amyloid-ß and tau, 2013-10-11

• The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable, 2018-12-21

• Effects of cognitive reserve depend on executive and semantic demands of the task, 2017-06-19

• Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer's dementia in mild cognitive impairment patients, 2022-03-29

• Neural signatures of experience-based improvements in deterministic decision-making, 2016-08-11

• Amyloid Imaging in Dementias With Atypical Presentation, 2012-01-30

• Disease course varies according to age and symptom length in Alzheimer's disease, 2018-07-29

• Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease, 2018-09-25

• Cognitive Decline Associated with Pathological Burden in Primary Age-Related Tauopathy, 2017-03-16

• Automated Volumetry and Regional Thickness Analysis of Hippocampal Subfields and Medial Temporal Cortical Structures in Mild Cognitive Impairment, 2014-09-02

• P50: A candidate ERP biomarker of prodromal Alzheimer's disease, 2015-08-06

• Subjective Memory Complaints, Cognitive Performance, and Psychological Factors in Healthy Older Adults, 2015-09-30

• Neural and behavioral correlates of episodic memory are associated with temporal discounting in older adults, 2020-07-02

• Increased Functional Connectivity within Medial Temporal Lobe in Mild Cognitive Impairment, 2012-07-20

• Relationship between Plasma Analytes and SPARE-AD Defined Brain Atrophy Patterns in ADNI, 2013-02-08

• Alzheimer's Dementia after Exposure to Anesthesia and Surgery in the Elderly: A Matched Natural Experiment using Appendicitis, 2020-11-17

• The relationship of contextual cueing and hippocampal volume in amnestic MCI patients and cognitively normal older adults, 2015-05-20

• Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan, 2019-12-09

• Ex vivoMRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology, 2021-12-14

• Microvascular Perfusion Based on Arterial Spin Labeled Perfusion MRI as a Measure of Vascular Risk in Alzheimer's Disease, 2013-04-17

• Subject-specific functional parcellation via Prior Based Eigenanatomy, 2014-05-20

• A comparison of Freesurfer and multi-atlas MUSE for brain anatomy segmentation: Findings about size and age bias, and inter-scanner stability in multi-site aging studies, 2020-08-27

• Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders, 2019-01-07

• Fractionating the Rey Auditory Verbal Learning Test: Distinct roles of large-scale cortical networks in prodromal Alzheimer's disease, 2019-03-28

• Quantitative detection of a-Synuclein and Tau oligomers and other aggregates by digital single particle counting, 2022-06-02

• Estimating regional cerebral blood flow using resting-state functional MRI via machine learning, 2019-11-19

• The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer's disease, 2018-03-05

• Familiarity-based memory as an early cognitive marker of preclinical and prodromal AD, 2013-03-06

• Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum, 2020-08-17

• Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration, 2019-07-03

• Longitudinal atrophy in early Braak regions in preclinical Alzheimer's disease, 2020-08-26

• Automatic Clustering and Thickness Measurement of Anatomical Variants of the Human Perirhinal Cortex, 2015-02-24

• Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology, 2021-10-24

• Cellular, synaptic and biochemical features of resilient cognition in Alzheimer's disease, 2012-05-02

• A deep learning model for early prediction of Alzheimer's disease dementia based on hippocampal MRI, 2019-06-11

• Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology, 2021-02-23

• Sensitive measures of cognition in Mild Cognitive Impairment, 2022-01-22

• Baseline structural MRI and plasma biomarkers predict longitudinal structural atrophy and cognitive decline in early Alzheimer's disease, 2023-04-11

• Multimodal In Vivo and Post-mortem Assessments of Tau in Lewy Body Disorders, 2020-08-21

• Disentangling heterogeneity in Alzheimer's disease and related dementias using data-driven methods, 2020-01-31

• Structural Correlation based Outlier Rejection (SCORE) algorithm for ASL time series, 2016-08-29

• Parietal Influence on Temporal Encoding indexed by simultaneous TMS and EEG, 2012-08-29

• Vascular Disease and Dementias: Paradigm Shifts to Drive Research in New Directions, 2012-11-22

• Medial temporal lobe subregional morphometry using high resolution MRI in Alzheimer's Disease, 2016-09-30

• Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease, 2020-04-22

• Cognitive and functional resilience despite molecular evidence of Alzheimer's disease pathology, 2012-11-02

• Predicting Cognitive Data from Medical Images Using Sparse Linear Regression, 2015-09-30

• The effects of aging and Alzheimer's disease on cerebral cortical anatomy: Specificity and differential relationships with cognition, 2013-03-16

• Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics, 2010-06-20

• Arterial spin labeled MRI in prodromal Alzheimer's disease: A multi-site study, 2013-04-30

• Amyloid imaging in Alzheimer's disease: comparison of Florbetapir and Pittsburgh Compound-B PET, 2012-07-11

• Ex vivo,in situperfusion protocol for human brain fixation compatible with microscopy, MRI techniques, and anatomical studies, 2023-03-23

• Diagnosing Mild Cognitive Impairment Among Racially Diverse Older Adults: Comparison of Consensus, Actuarial, and Statistical Methods, 2022-01-23

• DEEP GENERATIVE MEDICAL IMAGE HARMONIZATION FOR IMPROVING CROSS-SITE GENERALIZATION IN DEEP LEARNING PREDICTORS, 2021-09-25

• Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease, 2021-09-04

• Suspected non-AD pathology in Mild Cognitive Impairment, 2015-09-07

• Comparison of PASL, PCASL and background suppressed 3D PCASL in Mild Cognitive Impairment, 2017-07-24

• Tau-atrophy variability reveals phenotypic heterogeneity in Alzheimer's disease, 2021-10-15

• Update on Amyloid Imaging: From Healthy Aging to Alzheimer's Disease, 2010-01-21

• A framework for informing segmentation of in vivo MRI with information derived from ex vivo imaging: Application in the medial temporal lobe, 2017-09-12

• Effects of the Insulin Sensitizer Metformin in Alzheimer's Disease: Pilot Data from a Randomized Placebo-Controlled Crossover Study, 2017-04-15

• Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases, 2017-11-09

• Effects of task-set adoption on ERP correlates of controlled and automatic recognition memory, 2011-01-04

• Longitudinal and cross-sectional structural MRI correlates of AV-1451 uptake, 2018-02-09

• Tau PET Imaging Predicts Cognition in Atypical Variants of Alzheimer's Disease, 2017-11-06