Dr. David Sykes, MD

• Hematology

• Medical Oncology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Dana Farber Cancer Institute

  Fellowship Hospital

• Massachusetts General Hospital

  Residency Hospital

• Massachusetts General Hospital

  Internship Hospital

• University Of California, San Diego School Of Medicine

  Medical School

• Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia, 2016-09-15

• ENT1 blockade by CNX-774 overcomes resistance to DHODH inhibition in pancreatic cancer, 2022-10-27

• A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes, 2021-06-24

• Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity, 2022-04-29

• DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation, 2023-04-05

• Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses, 2021-09-21

• Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53, 2015-07-31

• Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression, 2022-12-01

• An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections, 2018-05-21

• TREM-1 IS REQUIRED FOR ENHANCED OpZ-INDUCED SUPEROXIDE GENERATION FOLLOWING PRIMING, 2022-01-24

• Modulating cell fate as a therapeutic strategy, 2018-06-14

• Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors, 2015-02-05

• DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma, 2022-09-08

• Employing enzymatic treatment options for management of ocular biofilm-based infections, 2019-01-28

• KAT6A and ENL form an epigenetic transcriptional control module to drive critical leukemogenic gene expression programs, 2022-03-01

• mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome, 2022-11-28

• Chromatin accessibility promotes hematopoietic and leukemia stem cell activity, 2020-03-16

• Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses toCandidaSpecies Negoro et al., 2020-05-12

• Case report: a 37-year-old male with telangiectasias, polycythemia vera, perinephric fluid collections, and intrapulmonary shunting, 2014-07-22

• Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance, 2020-08-06

• The metabolic regulator mTORC1 controls terminal myeloid differentiation, 2017-05-26

• JAK-inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia, 2022-01-14

• tiRNA signaling occurs via stress-regulated vesicle transfer in the hematopoietic niche, 2021-09-15

• RECQL5 suppresses oncogenic JAK2-induced replication stress and genomic instability, 2015-12-10

• Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control ofCandida glabratain Macrophages, 2018-05-16

• Host defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities?, 2021-07-29

• Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin, 2016-06-06

• Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes, 2022-06-02

• Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease, 2016-12-12

• Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging, 2022-11-24

• Toll-like Receptor Signaling Rescues Fungicidal Activity in Syk-deficient Neutrophils, 2022-03-11

• A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma, 2022-09-30

• SKAP2 is required for defense againstK. pneumoniaeinfection and neutrophil respiratory burst, 2020-04-30

• The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG, 2023-09-21

• Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses, 2023-02-07

• Biguanides enhance antifungal activity againstCandida glabrata VIRULENCE, 2018-08-01

• Multiparametric Profiling of Neutrophil Function via a High-Throughput Flow Cytometry-Based Assay, 2023-02-25

• Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment, 2021-10-15

• Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities, 2023-05-13

• SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating ß-catenin, 2013-01-30

• The hematopoietic stem cell niche, 2012-01-01

• Neuregulin1-ß decreases IL-1ß-induced neutrophil adhesion to human brain microvascular endothelial cells, 2014-05-28