Dr. Daniel Rader, MD

• Internal Medicine

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• Drexel University College Of Medicine

  Medical School, 1984

• Pre-Diabetic Obese Adolescents have a More Atherogenic Lipoprotein Profile Compared with Normoglycemic Obese Peers, 2012-05-22

• Association ofAPOC3Loss-of-Function Mutations with Plasma Lipids and Subclinical Atherosclerosis in the Multi-ethnic BioImage Study, 2015-11-03

• Multiancestry exome sequencing revealsINHBEmutations associated with favorable fat distribution and protection from diabetes, 2022-08-23

• Association of Inherited Mutations in DNA Repair Genes with Localized Prostate Cancer, 2021-10-25

• Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E[S], 2017-03-17

• Genomic Risk Stratification Predicts All-Cause Mortality After Cardiac Catheterization, 2018-10-24

• Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels, 2016-12-27

• Reducing the burden of disease and death from familial hypercholesterolemia: A call to action, 2014-09-16

• Genetic manipulation of theApoF/Stat2locus supports an important role for Type I Interferon signaling in atherosclerosis, 2014-01-10

• Recent Highlights of ATVB: Reporting Sex and Sex Differences in Preclinical Studies, 2018-08-22

• Endothelial lipase is a critical determinant of HDL-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium, 2013-05-30

• Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher, 2016-09-13

• Functional Analysis and Transcriptomic Profiling of iPSC-derived Macrophages and Their Application in Modeling Mendelian Disease, 2015-04-22

• Genetic coding variants in the niacin receptor,hydroxyl-carboxylic acid receptor 2 (HCAR2),and response to niacin therapy, 2017-06-15

• Plasma ApoC-III Levels, Triglycerides, and Coronary Artery Calcification in Type 2 Diabetics, 2015-06-11

• Lack of association between the Trp719Arg polymorphism in kinesin-like protein 6 and coronary artery disease in 19 case-control studies, 2010-11-02

• Genome-wide Association Study of Peripheral Artery Disease in the Million Veteran Program, 2019-07-08

• Exome-wide association study of plasma lipids in >300,000 individuals, 2017-10-30

• Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure, 2021-10-04

• Health care worker seromonitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration, 2021-08-23

• A drug screen using human iPSC-derived hepatocyte-like cells identifies cardiac glycosides as a potential treatment for hypercholesterolemia, 2017-04-06

• CRISPR/Cas9-mediated gene editing in human iPSC-derived macrophage reveals lysosomal acid lipase function in human macrophages, 2017-09-07

• Lack of MTTP protein in pluripotent stem cell-derived hepatocytes/cardiomyocytes abolishes apoB secretion and increases cell stress, 2017-05-16

• A null mutation inANGPTL8does not associate with either plasma glucose or type 2 diabetes in humans, 2016-01-28

• ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease, 2022-12-26

• Discovery and validation of new molecular targets in treating dyslipidemia: The role of human genetics, 2012-04-03

• Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of Atherosclerosis, 2010-10-19

• Dietary Vitamin E intake is associated with a reduced risk of developing digestive diseases and NAFLD, 2022-03-14

• Lack of Pathogenic GermlineDICER1Variants in Males with Testicular Germ-Cell Tumors, 2020-10-24

• Endothelial Lipase Concentrations Are Increased in Metabolic Syndrome and Associated with Coronary Atherosclerosis, 2005-12-20

• ILRUN Promotes Atherosclerosis through Lipid-dependent and Lipid-independent Factors, 2022-07-14

• A humanAPOC3missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels, 2017-08-21

• Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition, 2021-09-30

• Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease, 2022-03-03

• PathogenicLMNAvariants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes, 2021-02-01

• Causal assessment of serum urate levels in cardiometabolic diseases through a Mendelian Randomization study, 2016-02-02

• From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease, 2016-02-19

• Disrupting upstream translation in mRNAs is associated with human disease, 2021-03-09

• Cholesterol efflux and atheroprotection: Advancing the concept of reverse cholesterol transport, 2012-04-17

• FBN1coding variants and non-syndromic aortic disease, 2019-06-18

• Sequencing of 640,000 exomes identifiesGPR75variants associated with protection from obesity, 2021-07-02

• Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients, 2016-07-15

• Dynamic Changes in Central and Peripheral Neuro-Injury vs. Neuroprotective Serum Markers in COVID-19 Are Modulated by Different Types of Anti-Viral Treatments but Do Not Affect the Incidence of Late and Early Strokes, 2021-11-29

• LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase, 2020-08-17

• ANGPTL3 Inhibition With Evinacumab Results in Faster Clearance of IDL and LDL apoB in Patients With Homozygous Familial Hypercholesterolemia-Brief Report, 2021-03-11

• Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity, 2021-01-13

• Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program, 2020-09-28

• A genome-first approach to aggregating rare genetic variants inLMNAfor association with electronic health record phenotypes, 2019-08-06

• Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease, 2020-06-09

• Genetic variants influencing circulating lipid levels and risk of coronary artery disease, 2010-09-23

• ANGPTL3 Deficiency and Protection Against Coronary Artery Disease, 2017-04-03

• Genome-wide association Study of thoracic aortic aneurysm and dissection in the Million Veteran Program, 2023-06-12

• Rare genetic variants explain missing heritability in smoking, 2022-08-04

• Exome Sequencing in Suspected Monogenic Dyslipidemias, 2015-01-27

• MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data, 2021-11-11

• Common variants associated with plasma triglycerides and risk for coronary artery disease, 2013-10-06

• Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure, 2020-04-02

• Mining the stiffness-sensitive transcriptome in human vascular smooth muscle cells identifies long non-coding RNA stiffness regulators, 2017-10-19

• PCSK9loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort, 2020-11-09

• Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis, 2022-12-27

• Experimental Therapeutics for Challenging Clinical Care of a Patient with an Extremely Rare HomozygousAPOC2Mutation, 2020-03-27

• The potent and selective PPAR-a agonist LY518674 upregulates both apoA-I production and catabolism in human subjects with the metabolic syndrome, 2008-11-06

• TTC39B Deficiency Stabilizes LXR Reducing both Atherosclerosis and Steatohepatitis, 2016-07-14

• A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease, 2021-04-26

• A systematic review of the natural history and biomarkers of primary lecithin:cholesterol acyltransferase deficiency, 2022-01-20

• Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease, 2016-03-11

• Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Severe Hypercholesterolemia, 2016-04-03

• Novel ENU-Induced Point Mutation in Scavenger Receptor Class B, Member 1, Results in Liver Specific Loss of SCARB1 Protein, 2009-08-05

• Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity, 2017-04-12

• Association of the vitamin D metabolism geneCYP24A1with coronary artery calcification, 2010-09-16

• Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting, 2017-02-21

• The Evolution and Refinement of Traditional Risk Factors for Cardiovascular Disease, 2011-11-09

• Association of Statin Use With Risk of Liver Disease, Hepatocellular Carcinoma, and Liver-Related Mortality Statin Use and Risk of Liver Disease, Hepatocellular Carcinoma, and Liver-Related Mortality, 2023-06-26

• Targeting High Density Lipoproteins in the Prevention of Cardiovascular Disease?, 2012-11-30

• Genetic ablation ofAdamts13gene dramatically accelerates the formation of early atherosclerosis in a murine model, 2012-05-31

• Genetic regulation ofOAS1nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries, 2022-07-14

• Unmet Needs in Understanding Lipoprotein(a) Pathophysiology: NHLBI Working Group Recommendations to Reduce Risk of Cardiovascular Disease and Aortic Stenosis, 2018-01-16

• Genetics of Blood Lipids Among ~300,000 Multi-Ethnic Participants of the Million Veteran Program, 2018-10-01

• HDL Subclasses, Lipid Content, and Function trajectories across the Menopause Transition: SWAN-HDL Study, 2020-12-03

• ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice, 2020-09-11

• Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver, 2019-06-13

• The role of resting myocardial blood flow and myocardial blood flow reserve as a predictor of major adverse cardiovascular outcomes, 2020-02-13

• Relationship of Estimated GFR and Coronary Artery Calcification in the (CRIC) Chronic Renal Insufficiency Cohort Study, 2011-07-23

• Nuclear Receptors and microRNA-144 Coordinately Regulate Cholesterol Efflux, 2013-06-07

• Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of HDL-Cholesterol in Humans, 2018-05-29

• Genomics-first evaluation of heart disease associated with Titin-truncating variants, 2019-06-20

• CETP inhibition with Anacetrapib Decreases Fractional Clearance Rates of HDL Apolipoprotein A-I and Plasma CETP, 2016-03-10

• Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations, 2019-05-17

• US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry, 2016-08-06

• Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial, 2023-03-06

• Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations, 2021-01-11

• Macrophage Sortilin Promotes LDL Uptake, Foam Cell Formation, and Atherosclerosis, 2015-01-15

• The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population, 2022-11-29

• Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease, 2017-09-04

• Effects of Genetic Variants Associated with Familial Hypercholesterolemia on Low-Density Lipoprotein-Cholesterol Levels and Cardiovascular Outcomes in the Million Veteran Program, 2018-11-27

• Inhibition of endothelial lipase activity by sphingomyelin in the lipoproteins, 2014-08-29

• Genetic inactivation ofANGPTL4improves glucose homeostasis and is associated with reduced risk of diabetes, 2018-06-13

• Whole-genome sequencing reveals host factors underlying critical COVID-19, 2022-03-07

• Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease, 2020-08-30

• Genomic profiling of human vascular cells identifiesTWIST1as a causal gene for common vascular diseases, 2020-01-09

• Multiple rare alleles atLDLRandAPOA5confer risk for early-onset myocardial infarction, 2014-12-10

• Investigating the relationships between resilience, autism-related traits and mental health outcomes among adults during the COVID-19 pandemic, 2022-01-29

• Rare, Damaging DNA Variants inCORINand Risk of Coronary Artery Disease: Insights from Functional Genomics and Large-scale Sequencing Analyses, 2021-10-01

• The Effects of Apolipoprotein F Deficiency on High Density Lipoprotein Cholesterol Metabolism in Mice, 2012-02-20

• Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record data from European ancestry individuals, 2020-07-06

• The Trials and Tribulations of CETP Inhibitors, 2017-10-10

• Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program, 2020-05-06

• Association ofFADS1/2Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis Association ofFADS1/2Locus Variants With Polyunsaturated Fatty Acids and Aortic Stenosis, 2020-03-18

• The power of genetic diversity in genome-wide association studies of lipids, 2021-12-09

• A saturated map of common genetic variants associated with human height, 2022-10-12

• AAV Vectors Expressing LDLR Gain-of-Function Variants Demonstrate Increased Efficacy in Mouse Models of Familial Hypercholesterolemia, 2014-07-14

• Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells, 2015-08-17

• VLDL Hydrolysis by Hepatic Lipase Regulates PPARd Transcriptional Responses, 2011-07-05

• Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry, 2021-06-02

• Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study, 2017-08-24

• Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case forLDLRand Myocardial Infarction, 2015-02-03

• Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program, 2020-08-25

• Loss of function ofGALNT2lowers high density lipoproteins in humans, nonhuman primates, and rodents, 2016-08-09

• A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium, 2009-10-11

• GlycA Is a Novel Biomarker of Inflammation and Subclinical Cardiovascular Disease in Psoriasis, 2016-09-21

• Meta-analysis and imputation refines the association of 15q25 with smoking quantity, 2010-04-25

• Effect of Two Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial, 2018-04-11

• Whole genome sequence analysis of blood lipid levels in >66,000 individuals, 2022-10-11

• Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins, 2021-09-20

• Annual Report on Sex in Preclinical Studies - ATVB Publications in 2018, 2019-12-23

• Gain-of-function variants in lipid genes enhance biological insight and point toward therapeutic opportunities, 2022-09-06

• Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution, 2016-04-23

• Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry, 2013-06-30

• Cholesterol Efflux Capacity, HDL Particle Number, and Incident Cardiovascular Events An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin), 2017-04-27

• Genetic Variants Associated With Plasma Lipids Are Associated With the Lipid Response to Niacin, 2018-09-29

• A unified framework identifies novel links between plasma lipids and diseases from electronic medical records across large-scale cohorts, 2021-06-17

• Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways., 2020-02-17

• Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies, 2008-10-31

• Polygenic determinants in extremes of high-density lipoprotein cholesterol[S], 2017-09-04

• SARS-CoV-2 seroprevalence among parturient women in Philadelphia, 2020-07-29

• Genetic regulation ofOAS1nonsense-mediated decay underlies association with risk of severe COVID-19, 2021-07-13

• Large diverse population cohorts of hiPSCs and derived hepatocyte-like cells reveal functional genetic variation at blood lipid-associated loci, 2017-04-06

• Genomics and phenomics of body mass index reveals a complex disease network, 2022-12-29

• Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations, 2019-09-03

• Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort, 2023-01-19

• Fifteen new risk loci for coronary artery disease highlight arterial wall-specific mechanisms, 2017-05-22

• A genome-first approach to mortality and metabolic phenotypes inMTARC1p.Ala165Thr (rs2642438) heterozygotes and homozygotes, 2021-07-09

• Large-scale association analyses identifies 13 new susceptibility loci for coronary artery disease, 2011-03-06

• Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease, 2017-02-21

• Author Correction: The power of genetic diversity in genome-wide association studies of lipids, 2023-07-07

• A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease, 2015-09-07

• A Mendelian Randomization Analysis of Hemostatic Factors and their Contribution to Peripheral Artery Disease, 2020-08-27

• Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer's Disease, 2020-06-16

• Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders, 2022-06-01

• Practical Immunoaffinity-Enrichment LC-MS for Measuring Protein Kinetics of Low-Abundance Proteins, 2014-04-21

• Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease, 2019-11-01

• Association of serum androgens and coronary artery calcium scores in women, 2019-06-11

• Genetically Determined Birthweight Associates with Atrial Fibrillation: A Mendelian Randomization Study, 2020-04-27

• Loss of Cardio-Protective Effects at theADAMTS7Locus Due to Gene-Smoking Interactions, 2017-05-01