Dr. Dan Roden, MD

• Cardiology

• Internal Medicine

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Vanderbilt University / Medical Center

  Medical School, 1981

• SCN5A(NaV1.5) Variant Functional Perturbation and Clinical Presentation: Variants of a Certain Significance, 2018-03-30

• Benefit of pre-emptive pharmacogenetic information on clinical outcome, 2018-03-13

• Defining Phenotypes from Clinical Data to Drive Genomic Research, 2018-04-25

• Novel Rare Variants in Congenital Cardiac Arrhythmia Genes are Frequent in Drug-induced Torsades de Pointes, 2012-05-15

• Genome-wide Study Identifies Association between HLA-B*55:01 and Self-Reported Penicillin Allergy, 2020-09-03

• Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome, 2020-04-11

• Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes Mortality in Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes, 2022-05-11

• Association of step counts over time with the risk of chronic disease in theAll of UsResearch Program, 2022-10-10

• The polygenic architecture of left ventricular mass mirrors the clinical epidemiology, 2020-05-05

• Association of arrhythmia-related genetic variants with phenotypes documented in electronic medical records, 2016-01-05

• Deep Mutational Scan of anSCN5AVoltage Sensor, 2020-01-12

• Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile using Historical Data, 2016-10-25

• The AFFORD Clinical Decision Aid To Identify Emergency Department Patients With Atrial Fibrillation At Low Risk For 30-Day Adverse Events, 2015-01-06

• Phenotype-Driven Plasma Biobanking Strategies and Methods, 2015-05-14

• Characterization of Genome-Wide Association-Identified Variants for Atrial Fibrillation in African Americans, 2012-02-23

• Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease, 2017-02-21

• Common Genetic Polymorphism at 4q25 Locus Predicts Atrial Fibrillation Recurrence after Successful Cardioversion, 2013-02-19

• Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational study using electronic health records, 2018-08-28

• Family Screening after Sudden Death in a Population-Based Study of Children, 2022-04-01

• Kcnj11Ablation is Associated with Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy, 2017-01-26

• A phenome-wide association study to discover pleiotropic effects ofPCSK9,APOB, andLDLR, 2019-02-11

• Identification of Central Regulators of Calcium Signaling and ECM-Receptor Interaction Genetically Associated With the Progression and Recurrence of Atrial Fibrillation, 2018-05-16

• Examining Rare and Low-Frequency Genetic Variants Previously Associated with Lone or Familial Forms of Atrial Fibrillation in an Electronic Medical Record System: A Cautionary Note, 2014-11-19

• Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations, 2019-02-06

• Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing, 2013-11-19

• A Combined Genetic and Clinical Risk Prediction Model for Postoperative Atrial Fibrillation, 2015-01-07

• Association between titin loss-of-function variants and early-onset atrial fibrillation, 2018-12-11

• Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: a phenome-wide association study and inverse-variance weighted meta-analysis, 2021-05-12

• Candidate gene approach to identifying rare genetic variants associated with lone atrial fibrillation, 2013-10-10

• Genome-wide association study of platelet reactivity and cardiovascular response in patients treated with clopidogrel: a study by the International Clopidogrel Pharmacogenomics Consortium (ICPC), 2020-07-09

• Phenome-wide association studies demonstrating pleiotropy of genetic variants withinFTOwith and without adjustment for body mass index, 2014-08-05

• Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography, 2018-12-19

• Genomic contributors to atrial electroanatomical remodeling and atrial fibrillation progression: Pathway enrichment analysis of GWAS data, 2016-11-18

• Protein structure aids predicting functional perturbation of missense variants inSCN5AandKCNQ1, 2019-02-01

• Pediatric sample inclusion in an opt-out biorepository linking DNA to de-identified medical records: Pediatric BioVU, 2012-11-21

• Genome-wide study of resistant hypertension identified from electronic health records, 2017-02-21

• The influence of big (clinical) data and genomics on precision medicine and drug development, 2018-02-05

• Frequency of benign neutropenia among Black versus White individuals undergoing a bone marrow assessment, 2022-06-01

• Clinical Features Associated with Nascent Left Ventricular Diastolic Dysfunction in a Population Aged 40-55 Years, 2018-03-13

• Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults, 2017-05-04

• A Genotype Dependent Intermediate ECG Phenotype in Patients with Persistent Lone Atrial Fibrillation, 2009-02-01

• Identifying genetically driven clinical phenotypes using linear mixed models, 2016-04-25

• Association of Genetic Risk for Obesity with Postoperative Complications Using Mendelian Randomization, 2019-11-09

• Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network, 2019-04-15

• The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline forSLCO1B1and simvastatin-induced myopathy: 2014 update, 2014-06-11

• A Bayesian method to estimate variant-induced disease penetrance, 2020-06-22

• Leveraging human genetics to identify safety signals prior to drug marketing approval and clinical use, 2020-03-11

• Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets, 2023-09-27

• Phenotype risk scores identify patients with unrecognized Mendelian disease patterns, 2018-03-16

• Pharmacogenomics, 2019-08-05

• Atrial Fibrillation and Flutter Outcomes & Risk Determination (AFFORD): Design and rationale, 2011-08-04

• PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity, 2018-07-25

• A missense variant inPLECincreases risk of atrial fibrillation, 2017-10-24

• Multicenter Clinical and Functional Evidence Reclassifies a Recurrent Non-canonicalFilamin CSplice-altering Variant, 2023-05-09

• Hypogonadism as a reversible cause of Torsade de Pointes in men, 2018-07-03

• Coding variants inRPL3LandMYZAPincrease risk of atrial fibrillation, 2018-06-12

• Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol, 2019-05-23

• Race-Specific Impact of Atrial Fibrillation Risk Factors in Blacks and Whites in the Southern Community Cohort Study, 2012-08-23

• Building Evidence and Measuring Clinical Outcomes for Genomic Medicine, 2019-08-05

• Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization, 2014-06-22

• Influence of HLA alleles and KIR types on Heparin-Induced Thrombocytopenia, 2017-09-04

• Integrating EMR-Linked andIn VivoFunctional Genetic Data to Identify New Genotype-Phenotype Associations, 2014-06-20

• Development of a System for Post-marketing Population Pharmacokinetic and Pharmacodynamic Studies using Real-World Data from Electronic Health Records, 2020-02-11

• Dominant negative effects ofSCN5Amissense variants, 2022-03-16

• Accelerating Biomarker Discovery through Electronic Health Records, Automated Biobanking, and Proteomics, 2019-05-07

• A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin, 2016-09-23

• Systems biology and cardiac arrhythmias, 2012-10-27

• Attitudes of Clinicians Following Large-Scale Pharmacogenomics Implementation, 2015-08-11

• Predictive Accuracy of a Polygenic Risk Score for Postoperative Atrial Fibrillation After Cardiac Surgery, 2021-03-01

• Relation of the Severity of Obstructive Sleep Apnea in Response to Anti-Arrhythmic Drugs in Patients with Atrial Fibrillation or Atrial Flutter, 2012-04-18

• Generalization of Variants Identified by Genome-wide Association Studies for Electrocardiographic Traits in African Americans, 2013-03-28

• Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network, 2014-12-01

• Identification of unique venous thromboembolism-susceptibility variants in African-Americans, 2017-02-16

• Mechanistic Phenotypes: An Aggregative Phenotyping Strategy to Identify Disease Mechanisms Using GWAS Data, 2013-12-12

• Detection of distant relatedness in biobanks for identification of undiagnosed carriers of a Mendelian disease variant: application to Long QT Syndrome, 2023-09-15

• Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation, 2018-06-11

• Clinical and Genetic Determinants of Warfarin Pharmacokinetics and Pharmacodynamics during Treatment Initiation, 2011-11-16

• Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery, 2018-11-11

• A Genome-Wide Association Study to Identify Genomic Modulators of Rate Control Therapy in Patients with Atrial Fibrillation, 2014-06-06

• Daily Step Counts Before and After the COVID-19 Pandemic Among All of Us Research Participants Daily Step Counts Before and After the COVID-19 Pandemic, 2023-03-20

• ATrans-Ethnic Genome-Wide Association Study of Uterine Fibroids, 2019-06-12

• The phenotypic legacy of admixture between modern humans and Neanderthals, 2016-02-12

• Common ancestry-specific ion channel variants predispose to drug-induced arrhythmias, 2022-01-07

• Replication ofSCN5AAssociations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies, 2014-11-24

• A Partial Duplication and Poly(A) Insertion inKCNQ1Not Detected by Next-Generation Sequencing in Jervell and Lange-Nielsen Syndrome, 2016-05-19

• Comparison of HLA allelic imputation programs, 2017-02-16

• Early-Onset Atrial Fibrillation and the Prevalence of Rare Variants in Cardiomyopathy and Arrhythmia Genes Early-Onset Atrial Fibrillation and Rare Variant Prevalence in Cardiomyopathy and Arrhythmia Genes, 2021-09-08

• Admixture Mapping and Subsequent Fine-Mapping Suggests a Biologically Relevant and Novel Association on Chromosome 11 for Type 2 Diabetes in African Americans, 2014-03-03

• Increased long QT and Torsade de pointes reporting on tamoxifen compared to aromatase inhibitors., 2018-05-02

• Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans, 2017-03-28

• Arrhythmia variant associations and reclassifications in the eMERGE-III sequencing study, 2021-12-21

• A saturated map of common genetic variants associated with human height, 2022-10-12

• A Connexin 40 Mutation Associated with a Malignant Variant of Progressive Familial Heart Block Type-1, 2012-01-13

• Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel NaV1.5, 2022-02-17

• KCNH2pharmacogenomics summary, 2011-04-13

• Characterization of Statin Dose-response within Electronic Medical Records, 2013-10-04

• Cardiovascular Pharmacogenomics: Current Status and Future Directions-Report of a National Heart, Lung, and Blood Institute Working Group, 2012-04-24

• Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records, 2013-07-18

• A Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization, 2009-08-03

• Electronic Health Record Design and Implementation for Pharmacogenomics: a Local Perspective, 2013-09-05

• Relation of Morbid Obesity and Female Gender to Risk of Procedural Complications in Patients Undergoing Atrial Fibrillation Ablation, 2012-11-17

• A rare variant inMYH6is associated with high risk of sick sinus syndrome, 2011-03-06

• A Common Variant on Chromosome 4q25 is Associated With Prolonged PR Interval in Subjects With and Without Atrial Fibrillation, 2013-10-03

• Research directions in the clinical implementation of pharmacogenomics - An Overview of US programs and projects, 2018-03-30

• 2-Hydroxybenzylamine (2-HOBA) to prevent early recurrence of atrial fibrillation after catheter ablation: protocol for a randomized controlled trial including detection of AF using a wearable device, 2021-08-28

• SCN5Avariation is associated with electrocardiographic traits in the Jackson Heart Study, 2011-02-15

• The reckoning: The return of genomic results to 1444 participants across the eMERGE3 Network, 2022-02-23

• The 3D mutational constraint on amino acid sites in the human proteome, 2022-06-07

• How will Genetics Inform the Clinical Care of Atrial Fibrillation?, 2020-06-18

• LPAvariants are associated with residual cardiovascular risk in patients receiving statins, 2018-10-23

• Exome-wide association study of plasma lipids in >300,000 individuals, 2017-10-30

• Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-wide Association Studies, 2016-04-16

• Frequency of genomic incidental findings among 21,915 eMERGE network participants, 2020-06-17

• A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers, 2018-08-30

• Spectrum of cardiovascular toxicities of immune checkpoint inhibitors: A pharmacovigilance study, 2018-11-12

• Estimating the Post-Test Probability of Long QT Syndrome Diagnosis for RareKCNH2Variants, 2021-07-26

• Size matters: How population size influences genotype-phenotype association studies in anonymized data, 2014-07-16

• Opportunities and challenges in cardiovascular pharmacogenomics: From discovery to implementation, 2018-04-27

• Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation, 2017-04-17

• High Density GWAS for LDL Cholesterol in African Americans Using Electronic Medical Records Reveals a Strong Protective Variant inAPOE, 2012-08-23

• Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium, 2017-09-12

• Shared Decision Making in Cardiac Electrophysiology Procedures and Arrhythmia Management, 2021-12-06

• Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy, 2015-06-01

• An International Multi-Center Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition, 2020-01-16

• High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1, 2020-06-06

• Data re-identification: societal safeguards, 2013-03-01

• The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline forSLCO1B1, ABCG2, andCYP2C9and statin-associated musculoskeletal symptoms, 2022-03-11

• Biobanks and Electronic Medical Records: Enabling Cost-Effective Research, 2014-04-30

• SCN5AVariant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells, 2019-05-21

• Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype, 2021-09-20

• Genomic Medicine for Undiagnosed Diseases, 2019-08-05

• Inherited Causes of Clonal Hematopoiesis in 97,691 TOPMed Whole Genomes, 2020-10-14

• Genome-wide approach to measure variant-based heritability of drug outcome phenotypes, 2021-07-12

• A Polygenic Risk Score to Identify Subclinical Coronary Heart Disease Risk in Young Adults, 2021-08-31

• Common Atrial Fibrillation Risk Alleles at 4q25 Predict Recurrence after Catheter-based Atrial Fibrillation Ablation, 2012-11-23

• High-throughput framework for genetic analyses of adverse drug reactions using electronic health records, 2021-06-01

• Growing pains in cardiovascular genetics, 2018-09-18

• Atrial fibrillation is a complex trait. Very complex., 2020-07-02

• Using Systems Approaches to Address Challenges for Clinical Implementation of Pharmacogenomics, 2013-12-06

• Calcium Channel Blockers as Drug Repurposing Candidates for Gestational Diabetes: Mining large scale genomic and electronic health records data to repurpose medications, 2018-02-12

• Androgenic effects on ventricular repolarization: A translational study from the international pharmacovigilance database to iPSC-cardiomyocytes, 2019-08-05

• A Genome-Wide Association Study Identifies Variants inKCNIP4Associated with ACE Inhibitor Induced Cough, 2015-07-14

• Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis, 2023-09-05

• Using human ‘experiments of nature' to predict drug safety issues: an example with PCSK9 inhibitors, 2017-12-02

• Probing the virtual proteome to identify novel disease biomarkers, 2018-11-27

• Cardiovascular toxicities associated with hydroxychloroquine and azithromycin: an analysis of the World Health Organization pharmacovigilance database, 2020-05-22

• eMERGEing progress in genomics-the first seven years, 2014-06-17

• Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records, 2010-08-12

• Molecular characterization and investigation of the role of genetic variation in phenotypic variability and response to treatment in a large pediatric Marfan syndrome cohort, 2022-01-17

• Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery, 2018-07-01

• Evidence for Pharmacogenomic Effects on Risperidone Outcomes in Pediatrics, 2021-04-01

• Exome Sequencing Implicates an Increased Burden of Rare Potassium Channel Variants in the Risk of Drug Induced Long QT Syndrome, 2014-02-19

• Fulminant Myocarditis with Combination Immune Checkpoint Blockade, 2016-11-03

• The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin, 2012-10-17

• Investigating the Genetic Architecture of the PR Interval using Clinical Phenotypes, 2017-03-23

• Predictive models for abdominal aortic aneurysms using polygenic scores and PheWAS-derived risk factors, 2022-12-03

• Response - Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes., 2020-02-03

• Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record, 2017-07-07

• Management of Congenital Long QT Syndrome: Commentary from the Experts, 2021-07-09

• Enabling Genomic-Phenomic Association Discovery without Sacrificing Anonymity, 2013-02-06

• Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis - a phenome-wide association study and inverse-variance weighted meta-analysis, 2020-08-06

• Multiple mechanisms underlie increased cardiac late sodium current, 2019-01-21

• Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension, 2022-01-10

• Modulators of normal ECG intervals identified in a large electronic medical record, 2010-10-29

• Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction, 2020-05-21