Dr. Clifford Hudis, MD

• Medical Oncology

• Internal Medicine

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• Hospital Medical College Penn

  Residency Hospital, 1986

• Meml-sloan Kettering Center

  Fellowship Hospital, 1986

• Memorial Sloan-kettering Cancer Center

  Fellowship Hospital, 1986

• Hospital Medical College Penn

  Internship Hospital, 1984

• Medical College Penn

  Medical School, 1983

• Pre-operative immunotherapy with tumor cryoablation (cryo) plus ipilimumab (ipi) induces potentially favorable systemic and intratumoral immune effects in early stage breast cancer (ESBC) patients, 2015-08-14

• Efficacy and Safety of Gemcitabine With Trastuzumab and Pertuzumab After Prior Pertuzumab-Based Therapy Among Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer A Phase 2 Clinical Trial Gemcitabine With Trastuzumab and Pertuzumab Among Patients WithERBB2-Positiv, 2019-11-27

• Dietary Polyphenols Suppress Elevated Levels of Proinflammatory Mediators and Aromatase in the Mammary Gland of Obese Mice, 2013-07-23

• Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy, 2016-01-28

• Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index, 2017-03-07

• Optimizing Chemotherapy Dose and Schedule by Norton-Simon Mathematical Modeling, 2010-01-01

• Copper-64 trastuzumab PET imaging: A reproducibility study, 2016-05-12

• Correlative imaging reveals physiochemical heterogeneity of microcalcifications in human breast carcinomas, 2017-12-06

• White Adipose Tissue Inflammation and Cancer Specific Survival in Patients with Squamous Cell Carcinoma of the Oral Tongue, 2016-08-10

• Obesity and Inflammation: New Insights into Breast Cancer Development and Progression, 2014-01-10

• Prognostic value of quantitative fluorodeoxyglucose measurements in newly diagnosed metastatic breast cancer, 2013-09-12

• Genetic Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Mouse Mammary Tumor Growth and Angiogenesis, 2013-04-25

• p53 Expression in Node Positive Breast Cancer Patients: Results from the Cancer and Leukemia Group B (CALGB) 9344 Trial (159905), 2011-06-21

• Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis, 2015-08-19

• Omega-3 fatty acids for the prevention of breast cancer: an update and state of the science, 2013-05-07

• Hepatic resection or ablation for isolated breast cancer liver metastasis: A case-control study with comparison to medically treated patients, 2015-07-25

• A Randomized Multicenter Phase II Study of Docosahexaenoic Acid in Patients with a History of Breast Cancer, Premalignant Lesions or Benign Breast Disease, 2018-02-16

• Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland, 2011-01-29

• Axillary Management of Stage II/III Breast Cancer Patients Treated with Neoadjuvant Systemic Therapy: Results of CALGB 40601 (HER2-positive) and CALGB 40603 (Triple-negative), 2017-01-13

• Integrated analysis of RNA and DNA from the phase III trial CALGB 40601 identifies predictors of response to trastuzumab-based neoadjuvant chemotherapy in HER2-positive breast cancer, 2018-07-23

• Menopause is a Determinant of Breast Adipose Inflammation, 2015-02-26

• Obesity-associated breast inflammation among Hispanic/Latina breast cancer patients, 2018-11-07

• Appearance of untreated bone metastases from breast cancer on FDG PET/CT: Importance of histologic subtype, 2015-05-14

• PAM50 gene signatures and breast cancer prognosis with adjuvant anthracycline- and taxane-based chemotherapy: correlative analysis of C9741 (Alliance), 2016-01-06

• Gonadotropin-releasing hormone agonists for ovarian function preservation in premenopausal women undergoing chemotherapy for early stage breast cancer: a systematic review and meta-analysis, 2016-08-25

• Return to Work in Low-Income Latina and Non-Latina White Breast Cancer Survivors: A Three-Year Longitudinal Study, 2011-08-25

• Adiposity, Inflammation and Breast Cancer Pathogenesis in Asian Women, 2017-12-08

• Decreased gastrointestinal toxicity associated with a novel capecitabine schedule (7 days on and 7 days off): a systematic review, 2016-03-30

• Phase II Trial of Weekly Nanoparticle Albumin-Bound Paclitaxel With Carboplatin and Trastuzumab as First-line Therapy for Women With HER2-Overexpressing Metastatic Breast Cancer, 2010-08-01

• Breast Cancer, Version 3.2013 Featured Updates to the NCCN Guidelines, 2014-04-03

• Hydroxyapatite mineral enhances malignant potential in a tissue-engineered model of ductal carcinomain situ(DCIS), 2019-09-11

• Pioglitazone, a PPAR? Agonist, SuppressesCYP19Transcription: Evidence for Involvement of 15-Hydroxyprostaglandin Dehydrogenase and BRCA1, 2012-07-10

• Polygenic Inheritance of Paclitaxel-Induced Sensory Peripheral Neuropathy Driven by Axon Outgrowth Gene Sets in CALGB 40101 (Alliance), 2014-02-11

• The Genomic Landscape of Male Breast Cancers, 2016-03-09

• Increased levels of COX-2 and prostaglandin E2contribute to elevated aromatase expression in inflamed breast tissue of obese women, 2012-01-27

• Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer, 2011-05-27

• A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101, 2012-07-27

• A pilot study of preoperative single-dose ipilimumab and/or cryoablation in women with early- stage breast cancer with comprehensive immune profiling, 2016-08-26

• Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging and lung metastases in patients with breast cancer, 2013-03-26

• Identification of risk factors for toxicity in patients with hormone receptor-positive advanced breast cancer treated with bevacizumab plus letrozole: A CALGB 40503 (Alliance) correlative study., 2018-05-22

• RESILIENCE: Phase III Randomized, Double-Blind Trial Comparing Sorafenib With Capecitabine Versus Placebo With Capecitabine in Locally Advanced or Metastatic HER2-Negative Breast Cancer, 2017-05-22

• Acupuncture in the Treatment of Upper-Limb Lymphedema Results of a Pilot Study, 2013-04-10

• Trastuzumab interruption and treatment-induced cardiotoxicity in early HER2-positive breast cancer, 2015-01-01

• Magnetic Resonance Imaging as a Predictor of Pathologic Response in Patients Treated with Neoadjuvant Systemic Treatment for Operable Breast Cancer (TBCRC 017), 2013-02-21

• What is the Optimum Timing of Post-mastectomy Radiotherapy in Two-stage Prosthetic Reconstruction: Radiation to the Tissue Expander or Permanent Implant?, 2016-08-12

• Breast Carcinoma with Oncotype DX Recurrence Score Lower Than 18:Rate of Distant Metastases in a Large Series with Clinical Follow-Up, 2016-08-15

• Impact of Obesity on the Survival of Patients with Early Stage Squamous Cell Carcinoma of the Oral Tongue, 2014-01-21

• Pathological complete response in breast cancer patients receiving anthracycline and taxane-based neoadjuvant chemotherapy: Evaluating the effect of race/ethnicity, 2010-09-01

• Latent bone metastasis in breast cancer tied to Src-dependent survival signals, 2009-07-07

• Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation[S], 2016-06-01

• A phase 3 tRial comparing capecitabinE in combination with SorafenIb or pLacebo for treatment of locally advanced or metastatIc HER2-Negative breast CancEr (the RESILIENCE study): study protocol for a randomized controlled trial, 2013-07-22

• Adjuvant Chemotherapy and Trastuzumab Is Safe and Effective in Older Women With Small, Node-Negative, HER2-Positive Early-Stage Breast Cancer, 2016-08-01

• Bilateral Mastectomy versus Breast-Conserving Surgery for Early Stage Breast Cancer: The Role of Breast Reconstruction, 2016-01-14

• TBCRC 013: Prognostic Impact of 21-Gene Recurrence Score (RS) in Patients Presenting with Stage IV Breast Cancer, 2016-03-21

• Cardiac Safety of Non-Anthracycline Trastuzumab-Based Therapy for HER2-Positive Breast Cancer, 2017-07-14

• Leptin regulation of the p53-HIF1a/PKM2-aromatase axis in breast adipose stromal cells - a novel mechanism for the obesity-breast cancer link, 2017-11-06

• Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer, 2015-12-28

• Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update, 2016-09-19

• First-in-Human Trial of Epichaperome-Targeted Positron Emission Tomography in Cancer Patients, 2020-05-04

• Estrogen Protects Against Obesity Induced Mammary Gland Inflammation in Mice, 2015-06-02

• Metastatic Breast Cancer, Version 1.2012 Featured Updates to the NCCN Guidelines, 2012-07-01

• Caloric Restriction Reverses Obesity Induced Mammary Gland Inflammation in Mice, 2013-02-19

• A Phase II Trial of Erlotinib in Combination with Bevacizumab in Patients with Metastatic Breast Cancer, 2008-12-01

• Molecular Pathways:Adipose Inflammation as a Mediator of Obesity-Associated Cancer, 2013-08-19

• A Feasibility Study of Bevacizumab Plus Dose-Dense Doxorubicin-Cyclophosphamide (AC) Followed by Nanoparticle Albumin-Bound Paclitaxel in Early-Stage Breast Cancer, 2011-02-24

• MONARCH 1, a phase 2 study of abemaciclib, a CDK4 and CDK6 inhibitor, as a single agent, in patients with refractory HR+/HER2- metastatic breast cancer, 2017-05-22

• Estimating the OncotypeDX Score: Validation of an Inexpensive Estimation Tool, 2016-12-07

• Periprostatic adipose inflammation is associated with high-grade prostate cancer, 2017-06-27