Dr. Christopher Walsh, MD

• Pediatric Neurology

• Neurology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Massachusetts General Hospital, Neurology

  Residency Hospital, 1989

• Massachusetts General Hospital, Neurology And Genetics

  Fellowship Hospital, 1989

• University Of Chicago Pritzker School Of Medicine

  Medical School, 1985

• Massachusetts General Hospital, Medicine

  Internship Hospital, 1985

• Bucknell University

  Undergraduate School, 1978

• Biallelic Mutations In HumanDCCCause Developmental Split Brain Syndrome, 2017-02-27

• The exon junction complex componentMagohcontrols brain size by regulating neural stem cell division, 2010-04-04

• Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements, 2022-09-26

• Brain ventricles as windows into brain development and disease, 2022-01-05

• Variable disease severity in Saudi Arabian and Sudanese families with c.3924 + 2 T > C mutation ofLAMA2, 2011-12-13

• Whole-genome analysis reveals the contribution of non-coding de novo transposon insertions to autism spectrum disorder, 2021-11-27

• Somatic Mutation, Genomic Variation, and Neurological Disease, 2013-07-05

• A recurrent, homozygousEMC10frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features., 2021-02-02

• Phenotypic Heterogeneity in Woodhouse-Sakati Syndrome: Two New Families with a Mutation in the C2orf37 Gene, 2011-09-30

• The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing, 2021-01-11

• Developmental and Degenerative Features in a Complicated Spastic Paraplegia, 2009-11-30

• CC2D1ARegulates Human Intellectual and Social Function as well as NF-?B Signaling Homeostasis, 2014-07-24

• Regulation of human cerebral cortical development byEXOC7andEXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival, 2020-02-27

• The polymicrogyria-associatedGPR56promoter preferentially drives gene expression in developing GABAergic neurons in common marmosets, 2020-12-09

• Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network, 2017-04-27

• Targeted DNA sequencing from autism spectrum disorder brains implicates multiple genetic mechanisms, 2015-12-02

• Biallelic loss-of-function variants inWDR11are associated with microcephaly and intellectual disability, 2021-08-20

• Somatic mutation in pediatric neurological diseases, 2018-08-11

• The cerebrospinal fluid provides a proliferative niche for neural progenitor cells, 2011-03-10

• Microcephaly proteins Wdr62 and Aspm define a mother centriole complex regulating centriole biogenesis, apical complex and cell fate, 2016-10-27

• Somatic mutation in single human neurons tracks developmental and transcriptional history, 2015-10-02

• TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system, 2023-01-20

• Polymicrogyria is associated with pathogenic variants inPTEN, 2020-10-08

• PSMD12haploinsufficiency in a neurodevelopmental disorder with autistic features, 2018-11-13

• Glial dysregulation in the human brain in fragile X-associated tremor/ataxia syndrome, 2023-05-30

• Cux1andCux2regulate dendritic branching, spine morphology and synapses of the upper layer neurons of the cortex, 2010-05-27

• Common genetic variants, acting additively, are a major source of risk for autism, 2012-10-15

• Expanding the Spectrum of Rearrangements Involving Chromosome 19: A Mild Phenotype Associated with a 19p13.12-p13.13 Deletion, 2012-03-14

• Sequence analysis ofP21-activated kinase 3(PAK3) in chronic schizophrenia with cognitive impairment, 2008-09-20

• The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles, 2018-07-24

• Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity, 2022-08-11

• Delineation of the Clinical, Molecular and Cellular Aspects of NovelJAM3Mutations Underlying the Autosomal Recessive Hemorrhagic Destruction of the Brain, Subependymal Calcification and Congenital Cataracts, 2014-01-27

• Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factorDONSONas the cause of microcephaly-micromelia syndrome Mutation of genome replication factorDONSON, 2017-08-01

• Variants in ADD1 cause intellectual disability, corpus callosum dysgenesis, and ventriculomegaly in humans, 2021-11-30

• Loss of Non-motor Kinesin KIF26A Causes Congenital Brain Malformations via Dysregulated Neuronal Migration and Axonal Growth as well as Apoptosis, 2022-10-12

• Consistent chromosome abnormalities identify novel polymicrogyria loci in 1p36.3, 2p16.1-p23.1, 4q21.21-q22.1, 6q26-q27 and 21q2, 2008-07-01

• Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrentNRXN1andABCB11disruptions, 2023-07-06

• Synaptic, transcriptional, and chromatin genes disrupted in autism, 2014-10-29

• Innovations present in the primate interneuron repertoire, 2020-09-30

• Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry, 2008-07-11

• Candidate Gene Sequencing ofLHX2,HESX1, andSOX2in a Large Schizencephaly Cohort, 2010-08-27

• NFIAHaploinsufficiency Is Associated with a CNS Malformation Syndrome and Urinary Tract Defects, 2007-05-25

• New Innovations: Therapeutic opportunities for Intellectual disabilities, 2013-12-13

• Disorders of Microtubule Function in Neurons: Imaging Correlates, 2015-11-12

• A recurrent, homozygousEMC10frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features, 2021-02-02

• Genetic Causes of Microcephaly and Lessons for Neuronal Development, 2012-10-04

• APPgene copy number changes reflect exogenous contamination, 2020-08-19

• Candidate Gene Sequencing ofLHX2,HESX1, andSOX2in a Large Schizencephaly Cohort, 2010-10-11

• PDCD6IP, encoding a regulator of the ESCRT complex, is mutated in microcephaly, 2020-05-17

• Evolution of Osteocrin as an activity-regulated factor in the primate brain, 2016-11-10

• Identification of Neural Outgrowth Genes using Genome-Wide RNAi, 2008-07-04

• Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain, 2012-10-26

• Multiple recurrentde novocopy number variations (CNVs), including duplications of the 7q11.23 Williams-Beuren syndrome region, are strongly associated with autism, 2011-06-09

• RCL1copy number variants are associated with a range of neuropsychiatric phenotypes, 2021-02-17

• Clinical Genetic Testing for Patients With Autism Spectrum Disorders, 2010-03-15

• Rates, Distribution, and Implications of Post-zygotic Mosaic Mutations in Autism Spectrum Disorder, 2017-07-17

• Single Cell Analysis Reveals Transcriptional Heterogeneity of Neural Progenitors in the Human Cortex, 2015-03-03

• Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number, 2014-12-17

• Developmental and degenerative features in a complicated spastic paraplegia, 2010-12-29

• Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control, 2008-12-16

• Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder, 2022-06-10

• Aging and neurodegeneration are associated with increased mutations in single human neurons, 2017-12-07

• Somatic genomic changes in single Alzheimer's disease neurons, 2022-04-20

• Cell Type-specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex, 2016-08-25

• Ethnically Diverse Causes of Walker-Warburg Syndrome (WWS):FCMDMutations Are a More Common Cause of WWS Outside of the Middle East, 2008-08-27

• Homozygous Missense Variants inNTNG2,Encoding a Presynaptic Netrin-G2 Adhesion Protein, Lead to a Distinct Neurodevelopmental Disorder, 2019-10-24

• Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain, 2014-08-21

• Cerebral Cortical Neuron Diversity and Development at Single-Cell Resolution, 2016-11-23

• Delineation of aKDM2B-related neurodevelopmental disorder and its associated DNA methylation signature, 2022-11-01

• Microcephaly gene links Trithorax and REST/NRSF to control neural stem cell proliferation and differentiation, 2012-11-21

• Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain, 2023-01-14

• Mutations inWDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture, 2010-10-03

• Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2, 2014-05-12

• A genomewide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?, 2014-09-30

• Accurate detection of mosaic variants in sequencing data without matched controls, 2020-01-06

• Homozygous deletions implicate non-coding epigenetic marks in Autism spectrum disorder, 2020-08-20

• CHMP1Aencodes an essential regulator of BMI1-INK4A in cerebellar development, 2012-09-30

• Mutations in Human Accelerated Regions (HARs) Disrupt Cognition and Social Behavior, 2016-09-22

• Landmarks of human embryonic development inscribed in somatic mutations, 2021-03-19

• COL4A1Mutations Cause Ocular Dysgenesis, Neuronal Localization Defects, and Myopathy in Mice and Walker-Warburg Syndrome in Humans, 2011-05-19

• Somatic Copy Number Variants in Neuropsychiatric Disorders, 2021-01-11

• GPR56 promotes myoblast fusion through SRE- and NFAT-mediated signaling but is not essential for muscle developmentin vivo, 2013-10-08

• Novel Loss-of-Function Variants inDIAPH1Associated With Syndromic Microcephaly, Blindness, and Early Onset Seizures, 2015-10-13

• A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinctemx2mutant phenotype, 2011-01-07

• Evolutionarily Dynamic Alternative Splicing ofGPR56Regulates Regional Cerebral Cortical Patterning, 2014-02-14

• Genetic malformations of the human frontal lobe, 2014-11-18

• Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus, 2022-04-04

• Aspmknockout ferret reveals an evolutionary mechanism governing cerebral cortical size, 2018-04-11

• 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro, 2021-05-18

• Exome Sequencing and the Identification of New Genes and Shared Mechanisms in Polymicrogyria Exome Sequencing and the Identification of New Genes and Shared Mechanisms in Polymicrogyria, 2023-07-24

• Genetic Changes Shaping the Human Brain, 2015-02-23

• Mutations inPNKPcause microcephaly, seizures and defects in DNA repair, 2010-01-31

• Rewiring of human neurodevelopmental gene regulatory programs by Human Accelerated Regions (HARs), 2021-09-02

• Resolving rates of mutation in the brain using single-neuron genomics, 2016-02-22

• Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders, 2022-10-07

• De novo variants in TCF7L2 are associated with a syndromic neurodevelopmental disorder, 2021-05-18

• Schizencephaly: Association With Young Maternal Age, Alcohol Use, and Lack of Prenatal Care, 2012-12-23

• Posterior neocortex-specific regulation of neuronal migration by CEP85L identifies maternal centriole dependent activation of CDK5, 2020-02-24

• The Syndrome of Perisylvian Polymicrogyria with Congenital Arthrogryposis, 2009-09-13

• Comprehensive identification of somatic nucleotide variants in human brain tissue, 2021-03-29

• Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci, 2015-09-23

• Large mosaic copy number variations confer autism risk, 2021-01-11

• A Novel 2q37 Microdeletion Containing Human Neural Progenitors Genes IncludingSTK25Results in Severe Developmental Delay, Epilepsy, and Microcephaly, 2015-08-04

• Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations, 2012-04-12

• Autism and Brain Development, 2008-10-31

• Whole-Exome Sequencing and Homozygosity Analysis Implicate Depolarization-Regulated Neuronal Genes in Autism, 2012-04-12

• The apical complex couples cell fate and cell survival to cerebral cortical development, 2010-04-15

• Recessive gene disruptions in autism spectrum disorder, 2019-06-17

• Genomic Variants and Variations in Malformations of Cortical Development, 2015-04-01

• Analysis of somatic mutations in 131 human brains reveals aging associated hypermutability, 2022-07-28

• Deletions ofNRXN1(Neurexin-1) Predispose to a Wide Spectrum of Developmental Disorders, 2010-04-07

• Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy Contribution of Somatic Ras/Raf/MAPK Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy, 2023-05-01

• Deletions ofNRXN1(neurexin-1) predispose to a wide spectrum of developmental disorders, 2010-06-05

• Thoracic Aortic Aneurysm in Patients with Loss of FunctionFilamin AMutations: Clinical Characterization, Genetics, and Recommendations, 2019-11-28

• Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins, 2012-09-14

• Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication, 2015-08-22

• HomozygousPLCB1Deletion Associated with Malignant Migrating Partial Seizures in Infancy, 2012-06-12

• mTOR Pathway Mutations Cause Hemimegalencephaly and Focal Cortical Dysplasia, 2015-02-26

• Ion channel functions in early brain development, 2020-01-17

• Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait, 2013-06-06

• Somatic mutations activating the mTOR pathway in dorsal telencephalic progenitors cause a continuum of cortical dysplasias, 2017-12-26

• Expanding the clinical spectrum of biallelicZNF335variants, 2018-05-03

• Cell lineage analysis in human brain using endogenous retroelements, 2015-01-07

• Linked-read analysis identifies mutations in single-cell DNA sequencing data, 2019-03-18

• Rates and patterns of clonal oncogenic mutations in the normal human brain, 2021-08-13

• What disorders of cortical development tell us about the cortex: one plus one doesn't always make two, 2011-02-01

• Donnai-Barrow Syndrome (DBS/FOAR) in a Child With a HomozygousLRP2Mutation Due to Complete Chromosome 2 Paternal Isodisomy, 2008-07-15

• DCCmutation update: congenital mirror movements, isolated agenesis of the corpus callosum and developmental split brain syndrome, 2017-11-11

• Identification of a novelCNTNAP1mutation causing arthrogryposis multiplex congenita with cerebral and cerebellar atrophy, 2017-02-27

• Brain Somatic Mutation in Aging and Alzheimer's Disease, 2021-05-12

• MIPP-Seq: ultra-sensitive rapid detection and validation of low-frequency mosaic mutations, 2021-02-12

• Building a lineage from single cells: genetic techniques for cell lineage tracking, 2017-01-23

• Sodium channelSCN3A(NaV1.3) regulation of human cerebral cortical folding and oral motor development, 2018-08-23