Dr. Christine Seidman, MD

• Cardiology

• Internal Medicine

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• George Washington University School Of Medicine & Health Sciences

  Medical School, 1978

• Force generation via ß-cardiac myosin, titin, and a-actinin drives cardiac sarcomere assembly from cell-matrix adhesions, 2018-01-08

• DSAGE Identifies Osteopontin as a Downstream Effector of Integrin-Linked Kinase (ILK) in Cardiac-Specific ILK Knockout Mice, 2013-12-06

• Titin truncating variants affect heart function in disease cohorts and the general population, 2016-11-21

• The uptake of family screening in hypertrophic cardiomyopathy and an online video intervention to facilitate family communication, 2019-09-03

• Contribution of rare inherited andde novovariants in 2,871 congenital heart disease probands, 2017-10-09

• Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function, 2017-11-28

• Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC) R.A. de Boeret al., 2022-01-14

• Modeling humanTBX5haploinsufficiency predicts regulatory networks for congenital heart disease, 2020-12-14

• Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy, 2020-01-27

• Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease, 2015-01-14

• SarcTrack An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes, 2019-04-11

• Founder Mutation in N Terminus of Cardiac Troponin I Causes Malignant Hypertrophic Cardiomyopathy, 2020-09-04

• Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling, 2023-03-01

• Familial Dilated Cardiomyopathy caused by an Alpha-Tropomyosin Mutation: The Distinctive Natural History of Sarcomeric DCM, 2010-01-26

• Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies, 2022-08-05

• Advanced assessment of cardiac morphology and prediction of gene carriage by CMR in hypertrophic cardiomyopathy - the HCMNet/UCL collaboration, 2014-01-16

• Integrative analysis of PRKAG2 cardiomyopathy iPS and microtissue models identifies AMPK as a regulator of metabolism, survival and fibrosis, 2016-12-20

• THSD1 Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage, 2016-11-15

• The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine, 2014-03-20

• Association of Potentially Damaging De Novo Gene Variants With Neurologic Outcomes in Congenital Heart Disease Potentially Damaging Gene Variants and Neurologic Outcomes in Congenital Heart Disease, 2023-01-26

• Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease Damaging Variants in Genes and Increased Cancer Risk Among Patients With Congenital Heart Disease, 2020-10-21

• Pitx2modulates aTbx5-dependent gene regulatory network to maintain atrial rhythm, 2016-08-31

• Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy, 2019-04-16

• IL-11 is a crucial determinant of cardiovascular fibrosis, 2017-11-13

• Genetics of Congenital Heart Disease: The Glass Half Empty, 2013-02-15

• Cardiomyocyte infection byTrypanosoma cruzipromotes innate immune response and glycolysis activation, 2023-02-06

• A Comparison of Whole Genome Sequencing to Multi-Gene Panel Testing in Hypertrophic Cardiomyopathy Patients, 2017-09-25

• GATA6mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm, 2020-10-15

• The Muscle Bound Heart, 2019-06-24

• Spatial Transcriptional Profile of the Chick and Mouse Endocardial Cushions Identify Novel Regulators of Endocardial EMTin vitro, 2013-04-01

• Transcriptional Profiling of Cultured, Embryonic Epicardial Cells Identifies Novel Genes and Signaling Pathways Regulated by TGFßR3In Vitro, 2016-08-09

• Genetics of Hypertrophic Cardiomyopathy, 2010-05-18

• Research Priorities in Hypertrophic Cardiomyopathy: Report of a Working Group of the National Heart Lung and Blood Institute, 2010-09-14

• Complement genes contribute sex-biased vulnerability in diverse illnesses, 2020-05-11

• Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants inTNNI3andTNNT2That Are Common in Chinese Patients, 2020-08-20

• Paternal-age-related de novo mutations and risk for five disorders, 2019-07-10

• Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial, 2021-09-23

• CalTrack: High Throughput Automated Calcium Transient Analysis in Cardiomyocytes, 2021-05-21

• Genetic Testing for Dilated Cardiomyopathy in Clinical Practice, 2012-02-15

• An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery, 2018-08-13

• Genome-Widede novoVariants in Congenital Heart Disease Are Not Associated with Maternal Diabetes or Obesity, 2022-02-07

• Robust identification of mosaic variants in congenital heart disease, 2018-02-07

• De novomutations in Congenital Heart Disease with Neurodevelopmental and Other Birth Defects, 2015-12-04

• Clinical and Mechanistic Insights into the Genetics of Cardiomyopathy, 2016-12-27

• Genomic frontiers in congenital heart disease, 2021-07-16

• Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy, 2018-02-15

• Cells of the adult human heart, 2020-09-24

• Cardiomyocyte Proliferative Capacity Is Restricted in Mice WithLmnaMutation, 2021-06-23

• Activin type II receptor signaling in cardiac aging and heart failure, 2019-03-06

• CalTrack High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes, 2021-05-21

• UBQLN2Mutation Causing Heterogeneous X-linked Dominant Neurodegeneration, 2014-05-09

• Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association with Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis, 2022-05-10

• Diltiazem Treatment for Preclinical Hypertrophic Cardiomyopathy Mutation Carriers: A Pilot Randomized Trial to Modify Disease Expression, 2014-10-31

• Genome-Wide Assessment for Genetic Variants Associated with Ventricular Dysfunction after Primary Coronary Artery Bypass Graft Surgery, 2011-09-30

• Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis, 2012-01-22

• Damaging variants inFOXI3cause microtia and craniofacial microsomia, 2022-10-19

• Pathogenesis of Cardiomyopathy Caused by Variants inALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere, 2022-11-02

• A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice, 2016-02-05

• Macrophages Facilitate Electrical Conduction in the Heart, 2017-04-20

• Identifying Sarcomere Gene Mutations in HCM: A Personal History, 2011-03-18

• A Gene-Centric Strategy for Identifying Disease-Causing Rare Variants in Dilated Cardiomyopathy, 2018-06-11

• Molecular profiling of dilated cardiomyopathy that progresses to heart failure, 2016-05-05

• Allele-specific Silencing of MutantMyh6Allele in Mice Suppresses Hypertrophic Cardiomyopathy, 2013-10-04

• De NovoCopy Number Variants Identify New Genes and Loci in Isolated, Sporadic Tetralogy of Fallot, 2009-07-13

• NATRIURETIC PEPTIDE SYSTEM GENE VARIANTS ARE ASSOCIATED WITH VENTRICULAR DYSFUNCTION AFTER CORONARY ARTERY BYPASS GRAFTING, 2009-07-28

• Transcription Factor Protein Interactomes Reveal Genetic Determinants in Heart Disease, 2022-02-18

• Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies, 2016-02-26

• Molecular Genetics of Lidocaine-containing Cardioplegia in the Human Heart during Cardiac Surgery, 2018-07-17

• Prevention of Ventricular Arrhythmia and Calcium Dysregulation in a Catecholaminergic Polymorphic Ventricular Tachycardia Mouse Model Carrying Calsequestrin-2 Mutation, 2010-08-30

• A tension based model distinguishes hypertrophic versus dilated cardiomyopathy, 2016-04-21

• Filamin C cardiomyopathy variants cause protein and lysosome accumulation, 2021-08-18

• Using Next-generation RNA Sequencing to Examine Ischemic Changes Induced by Cold Blood Cardioplegia on the Human Left Ventricular Myocardium Transcriptome, 2014-12-13

• Structural variation across 138,134 samples in the TOPMed consortium, 2023-02-03

• Contribution of Non-Canonical Splice Variants to TTNtv Cardiomyopathy, 2021-08-31

• Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor, 2018-09-21

• The Cardiac Myosin Binding Protein C Arg502Trp Mutation: A Common Cause of Hypertrophic Cardiomyopathy, 2010-04-08

• A systematic approach to the reporting of medically relevant findings from whole genome sequencing, 2014-12-14

• Loss of RNA expression and allele-specific expression associated with congenital heart disease, 2016-09-27

• Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia, 2017-07-07

• Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors, 2018-03-22

• Functional Characterization of a Novel Mutation inNKX2-5Associated with Congenital Heart Disease and Adult-Onset Cardiomyopathy, 2013-05-09

• HOXA2Haploinsufficiency in Dominant Bilateral Microtia and Hearing Loss, 2013-07-11

• Genomic analyses implicate noncoding de novo variants in congenital heart disease, 2020-06-29

• Aggregate penetrance of genomic variants for actionable disorders in European and African Americans, 2016-11-09

• The Burden of Early Phenotypes and the Impact of Left Ventricular Wall Thickness on Hypertrophic Cardiomyopathy Sarcomere Mutation Carriers: Findings from the HCMNet Study, 2017-04-01

• Titin Mutations in iPS cells Define Sarcomere Insufficiency as a Cause of Dilated Cardiomyopathy, 2015-08-28

• Genetics of Cancer Therapy-Associated Cardiotoxicity, 2022-03-28

• EM-mosaic detects mosaic point mutations that contribute to congenital heart disease, 2020-04-29

• NKX2-5Mutations in an Inbred Consanguineous Population: Genetic and Phenotypic Diversity, 2015-03-06

• Effects of Losartan on Left Ventricular Hypertrophy and Fibrosis in Patients with Nonobstructive Hypertrophic Cardiomyopathy, 2014-02-08

• Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy, 2022-12-28

• Structural variation across 138,134 samples in the TOPMed consortium, 2023-01-25

• Reply to: MS #200906019, Yu H, et al., Whether B-type Natriuretic Peptide or Its Gene Polymorphism Predicts Patient's Outcome after Coronary Artery Bypass Graft Surgery?, 2009-11-05

• Fulminant Myocarditis with Combination Immune Checkpoint Blockade, 2016-11-03

• Different Transcriptomic Response toT. cruziInfection in hiPSC-Derived Cardiomyocytes From Chagas Disease Patients With and Without Chronic Cardiomyopathy, 2022-07-07

• The Good SHP2 Association: A Porthole into the Genetics of Congenital Heart Disease, 2012-06-04

• Closing the genotype-phenotype loop for precision medicine, 2017-10-17

• A Novel Role forCSRP1in a Lebanese Family with Congenital Cardiac Defects, 2017-12-18

• De novomutations in histone modifying genes in congenital heart disease, 2013-05-12

• Whole-Genome Sequencing as a First-Line Genetic Test in Familial Dilated Cardiomyopathy, 2018-07-02

• Congenital Heart Defects Due toTAF1Missense Variants, 2020-05-12

• Single-cell Resolution of Temporal Gene Expression during Heart Development, 2016-11-10

• Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature, 2022-10-10

• Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease, 2018-07-24

• De novoDamaging Variants, Clinical Phenotypes and Post-Operative Outcomes in Congenital Heart Disease, 2020-06-30

• ß-Myosin Heavy Chain Variant Met606Val Causes Very Mild Hypertrophic Cardiomyopathy in Mice, but Exacerbates HCM Phenotypes in Mice Carrying Other HCM Mutations, 2014-05-14

• Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles, 2020-11-20