Dr. Brian Rubin, MD

• Anatomic Pathology

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• Cornell University / New York State Statutory Colleges

  Medical School, 1995

• Immune Competency of aHairlessMouse Strain for Improved Preclinical Studies in Genetically-Engineered Mice, 2010-07-27

• Protein Kinase C iota as a Therapeutic Target in Alveolar Rhabdomyosarcoma, 2012-02-20

• PDGFRA Regulates Proliferation of Gastrointestinal Stromal Tumor Cells with Mutations inKITby Stabilizing ETV1, 2015-04-09

• An Adaptive Src-PDGFRA-Raf Axis in Rhabdomyosarcoma, 2012-08-30

• Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrentACTB-FOSBfusion in pseudomyogenic hemangioendothelioma, 2018-11-21

• Time to Treatment Initiation and Survival in Adult Localized High-Grade Bone Sarcoma, 2020-05-04

• Are acinic cell carcinomas of the breast and salivary glands distinct diseases?, 2015-03-23

• Membrane-To-Nucleus Signaling Links Insulin-Like Growth Factor-1- and Stem Cell Factor-Activated Pathways, 2013-10-07

• Gastrointestinal Stromal Tumors: Molecular Mechanisms and Targeted Therapies, 2011-04-14

• Preclinical Testing of Tandutinib in a Transgenic Medulloblastoma Mouse Model, 2018-04-11

• A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas, 2016-10-13

• Superficial low-grade fibromyxoid sarcoma, 2022-11-02

• Uterine adenosarcomas are mesenchymal neoplasms, 2015-12-28

• Positively selected enhancer elements endow osteosarcoma cells with metastatic competence, 2018-01-15

• Adult Primary Bone Sarcoma and Time to Treatment Initiation: An Analysis of the National Cancer Database, 2018-11-11

• MicroCT-Based Virtual Histology Evaluation of Preclinical Medulloblastoma, 2016-02-16

• Crimson Carrier, A Long-Acting Contrast Agent forIn VivoNear-Infrared Imaging of Injured and Diseased Muscle, 2010-06-03

• Recurrent hotspot mutations inHRASQ61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas, 2018-05-08

• Neurotensin Receptor 1 Is Expressed in Gastrointestinal Stromal Tumors but Not in Interstitial Cells of Cajal, 2011-02-18

• Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma, 2011-03-29

• Immunohistochemical Assessment ofHRASQ61R Mutations in Breast Adenomyoepitheliomas, 2020-02-09

• Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma, 2009-04-01

• Genomic profiling of primary and recurrent adult granulosa cell tumors of the ovary, 2020-03-12

• Loss-of-function mutations inATP6AP1andATP6AP2in granular cell tumors, 2018-08-30

• Preclinical Testing of Erlotinib in a Transgenic Alveolar Rhabdomyosarcoma Mouse Model, 2011-04-20

• A Postnatal Pax7+Progenitor Gives Rise to Pituitary Adenomas, 2010-04-01

• IL-4R Drives Dedifferentiation, Mitogenesis and Metastasis in Rhabdomyosarcoma, 2011-05-01

• Functional evaluation of therapeutic response for a mouse model of medulloblastoma, 2010-01-27

• Hotspot activatingPRKD1somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands, 2014-09-21

• The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas, 2016-05-26

• Genetic analysis of uterine adenosarcomas and phyllodes tumors of the breast, 2017-05-16

• Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery, 2016-07-14

• Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2, 2020-10-15

• Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors, 2019-12-18

• Identification of recurrentSMOandBRAFmutations in ameloblastomas, 2014-05-25

• Lack ofPRKD2andPRKD3kinase domain somatic mutations inPRKD1wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland, 2016-01-04

• Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying, 2017-04-21

• Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin), 2014-03-23

• Inactivation of Patched1 induces Pdgfra-positive Kit-negative GIST-like tumors in mice, 2012-10-03

• The capillary lobule variant of radiation-associated angiosarcoma in the setting of breast cancer: A diagnostic pitfall, 2022-10-10

• Adjuvant Radiation after Primary Resection of Atypical Lipomatous Tumors of the Extremity Reduces Local Recurrence but Increases Complications: A Multicenter Evaluation, 2022-08-22

• Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance, 2014-11-28

• Assessment ofHMGA2andPLAG1rearrangements in breast adenomyoepitheliomas, 2019-01-18

• Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours, 2019-02-22

• Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but noKITmutations, 2013-02-12

• Kitlowstem cells cause resistance to Kit/Pdgfra inhibitors in murine gastrointestinal stromal tumors, 2010-06-04

• Broad spectrum activity of the checkpoint kinase 1 inhibitor prexasertib as a single agent or chemopotentiator across a range of preclinical pediatric tumor models, 2018-12-18

• CAP-D3 Promotes Bacterial Clearance in Human Intestinal Epithelial Cells by Repressing Expression of Amino Acid Transporters, 2015-02-18

• Functional enhancers shape extrachromosomal oncogene amplifications, 2019-11-21

• Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave, 2021-04-26

• Incidence, demographics, and survival of malignant hemangioendothelioma in the United States, 2023-06-01

• Oncogenic properties and signaling basis of thePAX8-GLIS3fusion gene, 2020-05-21

• Correction: Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours, 2019-05-23

• NSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma: Implications for a Novel Oncogenic Mechanism, 2014-05-29

• Loss of H3K27 tri-methylation is a diagnostic marker for Malignant Peripheral Nerve Sheath Tumors and an indicator for an inferior survival, 2016-03-18

• Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex, 2022-04-13

• PAX8-GLIS3gene fusion is a pathognomonic genetic alteration of hyalinizing trabecular tumors of the thyroid, 2019-07-04